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Transportation noise and risk of stroke : a nationwide prospective cohort study covering Denmark

BACKGROUND: Studies on transportation noise and incident stroke are few and inconclusive. We aimed to investigate associations between road-traffic and railway noise and the risk of incident stroke in the entire Danish population.METHODS: We estimated road-traffic and railway noise (Lden) at the most and least exposed façades for all residential addresses across Denmark (2.8 million) for the perio

Road and railway noise and risk for breast cancer : A nationwide study covering Denmark

OBJECTIVE: Previous studies have suggested that transportation noise may increase risk for breast cancer, but existing literature is scarce and inconclusive. We aimed to investigate associations between road traffic and railway noise and risk for breast cancer across the entire Danish female population.METHODS: For all 2.8 million residential addresses across Denmark, we modelled road and railway

Surgically treated adult acquired flatfoot deformity: Register-based study of patient characteristics, health-related quality of life and type of surgery according to severity

BackgroundPopulation-level data describing patient characteristics and interventions used in surgical treatment of adult acquired flatfoot deformity (AAFD) is lacking.MethodsWe analyzed baseline patient-reported data including PROMs and surgical interventions for patients with AAFD reported to the Swedish Quality Register for Foot and Ankle Surgery (Swefoot) 2014–2021.Results625 feet with primary

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This article examines the role of welfare and social policies within broader eco-social transformations in a post-growth context by applyingthe concepts of sustainable welfare and ‘safe and just operating space’. It also provides an empirical analysis of the popularity of ecosocial policies designed to steer the economy and society towards this space: maximum and basic incomes, taxes on wealth and

Övervakning av fåglarnas populationsutveckling: : Årsrapport för 2022

I denna rapport redovisas populationstrender för 224 svenska fågelarter för olika långa tidsperioder, samt korttidstrender för 12 arter av större däggdjur. Fåglarna har räknats höst, vinter, vår och sommar enligt strikt standardiserade metoder. Sommar- respektive vinterpunktrutter har räknats sedan 1975, i huvudsak i södra Sverige. Standardrutterna räknas också på sommaren (sedan 1996)men täcker hWe present the results of the Swedish Bird Survey, a project run by the Department of Biology, Lund University, as a part of the National Monitoring Programme of the Swedish Environmental Protection Agency. The results for 2022 include data from: 546 winter point counts in 2021/2022 (47th winter), ofwhich 254 were carried out during the Christmas/New Year count, 209 summer point count routes (48th

The moral imperative of children’s academic excellence: Tensions and contradictions in Chinese middle-class parenting styles

It is well documented that Chinese parents invest enormous amounts of time, resources and emotions in their children’s education, as if a life worthwhile is a life where education and self-cultivation is at the fore. Taking part in and excelling in educational activities is a moral imperative that marks childhood, whereby achieving in school is not only an act of filial piety, but also a patriotic

Molecular characteristics of breast tumors in patients screened for germline predisposition from a population-based observational study

BackgroundPathogenic germline variants (PGVs) in certain genes are linked to higher lifetime risk of developing breast cancer and can influence preventive surgery decisions and therapy choices. Public health programs offer genetic screening based on criteria designed to assess personal risk and identify individuals more likely to carry PGVs, dividing patients into screened and non-screened groups.

Anticipating Artificial Intelligence in Mammography Screening : Views of Swedish Breast Radiologists

Objectives: Artificial intelligence (AI) is increasingly tested and integrated into breast cancer screening. Still, there are unresolved issues regarding its possible ethical, social and legal impacts. Furthermore, the perspectives of different actors are lacking. This study investigates the views of breast radiologists on AI-supported mammography screening, with a focus on attitudes, perceived be

The chronic stress risk phenotype mirrored in the human retina as a neurodegenerative condition

The brain is the key organ that orchestrates the stress response which translates to the retina. The retina is an extension of the brain and retinal symptoms in subjects with neurodegenerative diseases substantiated the eye as a window to the brain. The retina is used in this study to determine whether chronic stress reflects neurodegenerative signs indicative of neurodegenerative conditions. A 3-

Biomass residues as resources : An expanded life-cycle perspective

Biomass residues have been identified as potentially promising resources for production of bio-based products and fuels with low climate impacts. Unlike primary biomass such as crops, using residual biomass may avoid issues such as competition over land for food and feed production. To assess the climate impacts of products made from residual biomass, a life cycle assessment (LCA) may be used, butBiomass residues have been identified as potentially promising resources for production of bio-based products and fuels with low climate impacts. Unlike primary biomass such as crops, using residual biomass may avoid issues such as competition over land for food and feed production. To assess the climate impacts of products made from residual biomass, a life cycle assessment (LCA) may be used, but

Safety and pharmacokinetics of GB1211, an oral galectin-3 inhibitor : a single- and multiple-dose first-in-human study in healthy participants

PURPOSE: Galectin-3, a β-galactoside-binding lectin, plays a key role in several cellular pathways involved in chronic inflammation, heart disease and cancer. GB1211 is an orally bioavailable galectin-3 inhibitor, developed to be systemically active. We report safety and pharmacokinetics (PK) of GB1211 in healthy participants.METHODS: This phase 1, double-blind, placebo-controlled, first-in-human

A Sound Approach Toward a Mobility Aid for Blind and Low-Vision Individuals

Det finns runt 100 000 blinda och kraftigt synnedsatta individer (BKSI:er) i Sverige. Sådan synnedsättning leder till en kraftigt minskad förmåga för självständig förflyttning och lägre livskvalité, med ökad risk för arbetslöshet, trafikolyckor, en stillasittande livsstil och depression. Hälften av alla käpp- och hundanvändare är med om en huvudkollision årligen, och drygt var tredje för en fallolReduced independent mobility of blind and low-vision individuals (BLVIs) cause considerable societal cost, burden on relatives, and reduced quality of life for the individuals, including increased anxiety, depression symptoms, need of assistance, risk of falls, and mortality. Despite the numerous electronic travel aids proposed since at least the 1940’s, along with ever-advancing technology, the m

Fuzzing of PKCS#11 Trusted Application

The main goal of this thesis is to find an effective way to fuzz trusted applications (TAs) with source code residing in trusted execution environment (TEE). While fuzzing TAs has been previously done, no work has been found to utilize the source code of TAs to improve the fuzzing. Utilizing the source code in fuzzing can lead to an increase in code coverage compared to black-box fuzzing, and ther

Phytoglobins: Elucidation of Structural, Functional and Practical Features of Non-Symbiotic Plant Hemoglobins

Phytoglobins (Pgb) (plant hemoglobins) are heme-containing proteins and less well known in comparison to the mammalian counterparts hemoglobin (Hb) andmyoglobin (Mb). They share the same secondary structure as other globin-related proteins, six to eight α-helices comprising the myoglobin-fold (Mb-fold) with one prosthetic heme moiety per subunit. Pgbs are divided into different classes, where the Phytoglobins (Pgb) (plant hemoglobins) are heme-containing proteins and less well known in comparison to the mammalian counterparts hemoglobin (Hb) andmyoglobin (Mb). They share the same secondary structure as other globin-related proteins, six to eight α-helices comprising the myoglobin-fold (Mb-fold) with one prosthetic heme moiety per subunit. Pgbs are divided into different classes, where the

New aspects of allergic mechanisms and innate immunity in asthma. Alarmins as upstream mediators of asthma inflammation.

Asthma is a chronic inflammatory lung disease affecting over 300 million individuals worldwide. Both respiratory viral infections and aeroallergens have been identified as important risk factors for asthma. Rhinovirus (RV) infection has been recognized as a major cause of asthma exacerbations, and current research indicates that RV and allergens may have a synergistic effect, resulting in a higher

Possible heterogeneity of initial pancreatic islet beta-cell autoimmunity heralding type 1 diabetes

The etiology of type 1 diabetes foreshadows the pancreatic islet beta-cell autoimmune pathogenesis that heralds the clinical onset of type 1 diabetes. Standardized and harmonized tests of autoantibodies against insulin (IAA), glutamic acid decarboxylase (GADA), islet antigen-2 (IA-2A) and ZnT8 transporter (ZnT8A) allowed children to be followed from birth until the appearance of a first islet auto