The automotive industry has striven for fuel economy and resource efficiency through the deployment of powder metallurgy (PM) manufacturing processes for few decades. However, PM technology for transmission gears is currently only used at a small scale within the automotive industry. This is mainly due to: its shortcomings in material properties and performance gaps for final parts; lack of advanc

Several parameters and variables affect the production cost and the company competitiveness. The manufacturing part cost is directly influenced by factors related to tools, workpiece materials, equipment, personnel, automation, etc. These factors also have a significant influence on the manufacturing efficiency and performance. The presented model determines the production performance with respectSeveral parameters and variables affect the production cost and the company competitiveness. The manufacturing part cost is directly influenced by factors related to tools, workpiece materials, equipment, personnel, automation, etc. These factors also have a significant influence on the manufacturing efficiency and performance. The presented model determines the production performance with respect

Aims: To analyse dosimetric and clinical predictors for acute and late gastrointestinal toxicity following chemoradiotherapy of anal cancer. Materials and methods: Consecutive patients with locally advanced (T2 ≥4 cm – T4 or N+) anal cancer were selected from an institutional database (n = 114). All received intensity-modulated radiotherapy with concomitant 5-fluorouracil and mitomycin C. Gastroin

The syndecans are the major family of transmembrane proteoglycans,usually bearing multiple heparan sulfate chains. They are present onvirtually all nucleated cells of vertebrates and are also present in invertebrates, indicative of a long evolutionary history. Genetic models in bothvertebrates and invertebrates have shown that syndecans link to the actincytoskeleton and can fine-tune cell adhesion

Appropriate Wnt morphogen secretion is required to control animal development and homeostasis. Although correct Wnt globular structure is essential for secretion, proteins that directly mediate Wnt folding and maturation remain uncharacterized. Here, we report that protein disulfide isomerase-1 (PDI-1), a protein-folding catalyst and chaperone, controls secretion of the Caenorhabditis elegans Wnt

The Caenorhabditis elegans (C. elegans) germline is used to study several biologically important processes including stem cell development, apoptosis, and chromosome dynamics. While the germline is an excellent model, the analysis is often two dimensional due to the time and labor required for three-dimensional analysis. Major readouts in such studies are the number/position of nuclei and protein

Burr formation is a problematic aspect in the machining of ductile metals. Understanding the formation mechanism and being able to model the plastic workpiece behavior during tool exits is key to burr minimization. A 3D finite element model is used to simulate burr formation during the exit phase of intermittent turning of AISI 4140, using a nose radiused insert. The model is validated by experime

Cytosolic calcium is an important factor during fertilization, development and differentiation. Hence, the control of cytosolic calcium levels has been studied extensively for several decades. Numerous calcium channels have been identified and their mechanism of action elucidated. However, the mode of calcium channel regulation remains elusive. Here we discuss our recent findings regarding the rol

Intermittent turning the slotted workpieces is always accompanied with a high impact load of the machine tool during the entry phase of the cutting edge. The process leads to a strong dynamic response of the system and results in vibrations arose and potential tool life and surface finish issues. The present study addresses the modeling of cutting force build-up process with further optimization o

The transcription factor SOX2 is a well-established and important stem cell marker. Its role in cancer biology remains unclear, but it has been proposed to also be a marker of cancer stem cells. We investigated the role of SOX2 protein expression in women with high-grade serous ovarian cancer (HGSOC) to determine its potential prognostic and treatment predictive value. We constructed a tissue micr

Septic shock, a serious consequence of disseminated infection that has a high mortality, is due to a dysregulated, severe immune response triggered by the infection. Acute phase reactants play key roles in sepsis, for example, hepcidin regulating iron metabolism. Reticulocyte haemoglobin (Ret-He) depends on available iron in blood, indirectly regulated by hepcidin. This study aimed at exploring ra

Existing state-of-the-art estimation systems can detect 2d poses of multiple people in images quite reliably. In contrast, 3d pose estimation from a single image is ill-posed due to occlusion and depth ambiguities. Assuming access to multiple cameras, or given an active system able to position itself to observe the scene from multiple viewpoints, reconstructing 3d pose from 2d measurements becomes

Transcriptional profiling of acute leukemia, specifically by RNA-sequencing or whole transcriptome sequencing (WTS), has provided fundamental insights into its underlying disease biology and allows unbiased detection of oncogenic gene fusions, as well as of gene expression signatures that can be used for improved disease classification. While used as a research tool for many years, RNA-sequencing

In order to develop a sensitive, versatile and inexpensive portable instrument, a calorimetric micro-biosensor was designed and fabricated by etching part of the flow system into a silicon wafer. The utility of the device was tested using the enzymes, catalase and penicillinase. This sensor showed good reproducibility and linearity up to 100 mM. The system also showed higher sensitivity than the c