Nine polypeptides of gastrointestinal origin were tested for their possible effect on vascular smooth muscle of the rat portal vein. The substances tested were bombesin, caerulein, glucagon, insulin, pentagastrin, secretin, somatostatin, substance P and vasoactive intestinal polypeptide (VIP). Cumulative dose-response relations of integrated mechanical activity (mean tension) were obtained with ma

In this article the concept of trade or retail bindings with regard to the Swedish book market during the 18th and early 19th century is introduced and discussed. Binding techniques and materials as well as the cost of different kinds of Swedish trade bindings are shown. Special attention is given to the large production of almanacs, hymnbooks and ABC books destined for the peasantry. Complaints a

Kinin B-1 receptors (B1R) are involved in many pathophysiological processes, and its expression is up-regulated in inflammatory pulmonary disease. Although bacteria can generate kinin peptides, the molecular signaling mechanisms regulating B1R during infection by intact pathogens is unknown. The serious opportunistic clinical isolate Burkholderia cenocepacia (B. cen.) belongs to the important B. c

Popular Abstract in Swedish N-acyletanolaminer (NAE) tillhör en växande grupp av kroppsegna lipider, som påverkar en mängd olika receptorer och jonkanaler. En sådan substans är anandamid, som finns i hjärnan och många andra organ. 1992 visade en grupp forskare att anandamid aktiverar receptorn för ?9-tetrahydrocannabinol (cannabinoidreceptorn) i centrala nervsystemet. Anandamid och andra NAE bildaN-acylethanolamines (NAEs) belong to a growing family of endogenous signalling molecules acting on a variety of receptors and ion channels. In 1992, it was reported that the N-acylethanolamine anandamide is present in the brain and activates the central cannabinoid (CB) receptor. Anandamide and other NAEs are considered to be generated on demand following receptor activation or cell stress. The ti

Nine patients with spondylarthropathy (SpA) (6 with ankylosing spondylitis and 3 with psoriatic arthritis) who had not responded properly to conventional DMARD therapy were treated with 3 infusions (at 0, 2 and 6 weeks) of the TNF alpha inhibitor infliximab (3 mg/kg), in combination with methotrexate. To measure the effect of treatment, patients were evaluated before as well as 8 and 12 weeks afte

A more than 40-year-long process came to an end when relations between the Church of Sweden and the state were formally changed in the year 2000. Social Democrats and Liberals had taken the initiative in the 1950s. Several proposals for disestablishment were put forward in the 1970s, but none of them. achieve political consensus. In addition, the representatives for all the political parties on th

This study aims to investigate the possibility of implementing serial autoradiography using a silicon strip detector as an imaging modality in pre-clinical radionuclide therapy research, in order to study the effect of non-uniform uptake on absorbed dose distribution and biological response. Tumor tissues expressing CD20 (B-cell lymphoma) or carcinoembryonic antigen (CEA; colorectal cancer) were e

Programming languages are the main tools used to describe models of the real world and algorithms which manipulate these models. Over time much effort has been devoted to the task of making programming languages more high-level by enhancing their expressiveness, bringing it closer to the way the programmer thinks and reasons. The development of object-oriented programming languages is one importan

Popular Abstract in Swedish Vad har den slaviskt inspirerade östersjökeramiken som arkeologer finner i Skandinavien med slaver att göra? Levde de som gäster i huset? Vikingen och hanseaten har sedan länge sina platser inbokade på den historiska scenen. Under äldre medeltid rörde sig även andra aktörer över Östersjöns vatten. Främmande gäster besökte och bosatte sig i Skandinavien. Bland dem fanns Scholarly texts on Slavic-Scandinavian relations have concentrated on two main areas of interest. During the Viking Age the economic and social contacts between the lake Mälaren district and Rus’ were extensive. However, at the beginning of the Middle Ages, political antagonism between the two expanding realms of the Svear and the Novgorodians is noticeable. In southern Scandinavia, the hostility

Thin layers of GaxIn1-xP grown on top of self-assembled InP quantum dots has been studied using transmission electron microscopy (TEM), scanning tunneling microscopy (STM), and low-temperature scanning tunneling luminescence (STL). STM reveals that the overgrowth is highly uneven, in which elongated GaxIn1-xP islands covering the dots are formed. TEM and high-spatial-resolution STL show that the q

The inclusive e(+)p single and double differential cross sections for neutral and charged current processes axe measured with the H1 detector at HERA. The data were taken in 1999 and 2000 at a centre-of-mass energy of roots = 319 GeV and correspond to an integrated luminosity of 65.2 pb(-1). The cross sections are measured in the range of four-momentum transfer squared Q(2) between 100 and 30 000

In this article we present the first theoretical study of solvent effects on the rotatory strength tensor. The system chosen is solvated formaldehyde for which only one tensor element is nonvanishing, and the solvent is modeled as a linear, homogeneous, and isotropic dielectric continuum. We present results using both an equilibrium and a nonequilibrium description of the solvent. Four illustrativ

Objective: To test the hypothesis that sub-optimal factors in perinatal care services resulting in perinatal deaths were more common among immigrant mothers from the Horn of Africa, as compared to Swedish mothers. Design: A perinatal audit, comparing cases of perinatal deaths among children of African immigrants residing in Sweden, with a stratified sample of cases among native Swedish women. Se

The main functions of viral capsids are to protect, transport and deliver their genome. The mechanical properties of capsids are supposed to be adapted to these tasks. Bacteriophage capsids also need to withstand the high pressures the DNA is exerting onto it as a result of the DNA packaging and its consequent confinement within the capsid. It is proposed that this pressure helps driving the genom

Sixty-six patients operated on for isolated cleft palate were evaluated as adults, and their speech was assessed clinically. Forty-four had undergone a von Langenbeck repair at the age of 7 months and 22 a Wardill repair at the age of 18 months. Speech was judged subjectively by the patients themselves, and perceptual assessment was made by three speech pathologists. The remaining speech problems,

Levels of nonantigen-induced pro-inflammatory cytokines and prostaglandin in macrophages isolated from human leucocyte antigen (HLA)-matched type 1 diabetes mellitus patients, first-degree relatives and healthy controls were determined. We hypothesize that monocytes isolated from patients are sensitized or preactivated and therefore, have an altered response to in vitro stimulus compared with cont