Sökresultat
Filtrera
Filtyp
Din sökning på "*" gav 531231 sökträffar
No title
No title
Why Control Immigration? Strategic Uses of Migration Management in Russia. By Caress Schenk. Toronto: University of Toronto Press, 2018. xvi, 374 pp. Appendix. Notes. Bibliography. Index. Figures. Tables. $71.25, hard bound.
Patients' and physicians' disagreement on patients' understanding of clinical cancer trial information : A pairwise pilot study of mirroring subjective assessments compared with objective measurements
Background: Informed consent is a prerequisite for patients included in clinical trials. Trial design, inclusion criteria and legal requirements are increasingly complex. This complexity challenges design and delivery of written and oral trial information to ensure understandable information. To evaluate the level of concordance between patients' and informing physicians' assessments regarding pat
Identification of two abundant Aerococcus urinae cell wall-anchored proteins
Aerococcus urinae is an emerging pathogen that causes urinary tract infections, bacteremia and infective endocarditis. The mechanisms through which A. urinae cause infection are largely unknown. The aims of this study were to describe the surface proteome of A. urinae and to analyse A. urinae genomes in search for genes encoding surface proteins. Two proteins, denoted Aerococcal surface protein (A
Shaping the future of migraine targeting Calcitonin-Gene-Related-Peptide with the Disease-Modifying Migraine Drugs (DMMDs)
Carbon dynamics, net primary productivity and human-appropriated net primary productivity across a forest–cocoa farm landscape in West Africa
Terrestrial net primary productivity (NPP) is an important metric of ecosystem functioning; however, there are little empirical data on the NPP of human-modified ecosystems, particularly smallholder, perennial crops like cocoa (Theobroma cacao), which are extensive across the tropics. Human-appropriated NPP (HANPP) is a measure of the proportion of a natural system's NPP that has either been reduc
Centennial-long trends of lake browning show major effect of afforestation
Observations of increasing water color and organic carbon concentrations in lakes are widespread across the Northern Hemisphere. The drivers of these trends are debated. Declining atmospheric sulfur deposition has been put forward as an important underlying factor, since recovery from acidification enhances mobility of organic matter from surrounding soils. This would suggest that the current brow
Beyond respiration : Controls on lateral carbon fluxes across the terrestrial-aquatic interface
Understanding what controls the lateral flux of organic and inorganic carbon from landscapes to surfacewaters is key to fully understanding terrestrial ecosystem carbon balances, the biogeochemistry of fresh-waters, and how the hydrologically-mediated movement of carbon between these ecosystems may be alteredby global change. In this paper, we synthesize current knowledge and identify major knowled
Exploring the xylose paradox in Saccharomyces cerevisiae through in vivo sugar signalomics of targeted deletants
Background: There have been many successful strategies to implement xylose metabolism in Saccharomyces cerevisiae, but no effort has so far enabled xylose utilization at rates comparable to that of glucose (the preferred sugar of this yeast). Many studies have pointed towards the engineered yeast not sensing that xylose is a fermentable carbon source despite growing and fermenting on it, which is
Early recognition and treatment of neuropsychiatric symptoms to improve quality of life in early Alzheimer's disease : Protocol of the BEAT-IT study
Background: Neuropsychiatric symptoms (NPS) are very common in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia and are associated with various disadvantageous clinical outcomes including a negative impact on quality of life, caregiver burden, and accelerated disease progression. Despite growing evidence of the efficacy of (non)pharmacological interventions to re
Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases
Enzymes with a protein kinase fold transfer phosphate from adenosine 5'-triphosphate (ATP) to substrates in a process known as phosphorylation. Here, we show that the Legionella meta-effector SidJ adopts a protein kinase fold, yet unexpectedly catalyzes protein polyglutamylation. SidJ is activated by host-cell calmodulin to polyglutamylate the SidE family of ubiquitin (Ub) ligases. Crystal structu
Arguments for a Phenomenologically Informed Clinical Approach to Autism Spectrum Disorder
Objective: The aim of this paper is to provide arguments for a phenomenologically informed clinical approach to autism spectrum disorder (ASD), including a plea for clinical attention to the self in ASD. Methods: Central concepts of continental phenomenology, phenomenological psychopathology, and the phenomenological interview are presented, with an emphasis on the potential unifying qualities of
Highly Strained III-V-V Coaxial Nanowire Quantum Wells with Strong Carrier Confinement
Coaxial quantum wells (QWs) are ideal candidates for nanowire (NW) lasers, providing strong carrier confinement and allowing close matching of the cavity mode and gain medium. We report a detailed structural and optical study and the observation of lasing for a mixed group-V GaAsP NW with GaAs QWs. This system offers a number of potential advantages in comparison to previously studied common group
Biological treatment of ankylosing spondylitis : A nationwide study of treatment trajectories on a patient level in clinical practice
Background: There is substantial evidence that patients with ankylosing spondylitis (AS) have high response rates to tumour necrosis factor inhibitors (TNFi), a low likelihood of successful treatment termination, but yet a limited drug retention. Whereas several reports have assessed drug retention rates for TNFi in AS, there are few, if any, studies investigating the actual treatment trajectories
Albumin infusion rate and plasma volume expansion : A randomized clinical trial in postoperative patients after major surgery
Background: Optimal infusion rate of colloids in patients with suspected hypovolemia is unknown, and the primary objective of the present study was to test if plasma volume expansion by 5% albumin is greater if fluid is administered slowly rather than rapidly. Methods: Patients with signs of hypoperfusion after major abdominal surgery were randomized to intravenous infusion of 5% albumin at a dose
Disciplinary discernment : Reading the sky in astronomy education
This theoretical paper introduces a new way to view and characterize learning astronomy. It describes a framework, based on results from empirical data, analyzed through standard qualitative research methodology, in which a theoretical model for a vital competency of learning astronomy is proposed: reading the sky, a broad description under with various skills and competencies are included. This m
The importance of emotional distress, cognitive behavioural factors and pain for life impact at baseline and for outcomes after rehabilitation - A SQRP study of more than 20,000 chronic pain patients
Although literature concerning chronic pain patients indicates that cognitive behavioural variables, specifically acceptance and fear of movement/(re)injury, are related to life impact, the relative roles of these factors in relation to pain characteristics (e.g. intensity and spreading) and emotional distress are unclear. Moreover, how these variables affect rehabilitation outcomes in different s
Transition governance for energy efficiency - Insights from a systematic review of Swedish policy evaluation practices
Background: The transition towards a more sustainable energy system is urgent for addressing global environmental and social challenges, and will require transformative changes including improved energy efficiency in the built environment. To reach identified efficiency potentials, various policy instruments have been introduced but their effects are often unclear. In this paper, we argue that the