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Summary: The relationship between rheumatoid arthritis (RA) and fracture risk was estimated in an international meta-analysis of individual-level data from 29 prospective cohorts. RA was associated with an increased fracture risk in men and women, and these data will be used to update FRAX®. Introduction: RA is a well-documented risk factor for subsequent fracture that is incorporated into the FRA
Context. Wind dynamics play a pivotal role in governing transport processes within planetary atmospheres, influencing atmospheric chemistry, cloud formation, and the overall energy budget. Understanding the strength and patterns of winds is crucial for comprehensive insights into the physics of ultra-hot-Jupiter atmospheres. Current research has proposed different mechanisms that limit wind speeds
Importance: Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive symptoms and amyloid pathology. Objective: To examine the association between depressive symptoms and amyloid pathology and its dependency on age,
The medieval church and cemetery of Westerhus (Västerhus) is situated on the island of Frösön in the province of Jämtland, Mid-Sweden. The site was completely excavated and underwent anthropological analysis, published by Nils-Gustaf Gejvall in 1960. A number of early radiocarbon datings were later obtained (Gejvall 1968). In 2009 a new study of the church, site, burials and humans was presented b
Inherited retinal diseases (IRDs) are a genetically heterogeneous group of Mendelian disorders that often lead to progressive vision loss and involve approximately 300 distinct genes. Although variants in these loci account for the majority of molecular diagnoses, other genes associated with IRD await molecular identification. In this study, we uncover bi-allelic assortments of 23 different (22 lo
The atmosphere, ocean, and sea ice components in Earth system models are coupled via boundary conditions at the sea surface. Standard coupling algorithms correspond to the first step of an iteration, so-called Schwarz waveform relaxation. Not iterating is computationally cheap but introduces a numerical coupling error, which we aim to quantify for the case of a coupled single column model: the EC-
Background This prospective cohort study aimed to assess whether postoperative radiotherapy could safely be omitted in women aged 65 years and older with low-risk, estrogen receptor-positive T1N0 breast cancer treated with breast-conserving surgery and adjuvant endocrine therapy. Methods Eligible patients were women aged 65 years and older with unifocal, nonlobular, grade 1 or 2, estrogen receptor
Eddy covariance measurement of species that are co-emitted with carbon dioxide (CO2), such as carbon monoxide (CO) and nitrogen oxides NO and NO2 (NOx), provides an opportunity to attribute a net flux to individual source or sink categories. We present eight months of continuous simultaneous measurements of fluxes (F) of CO2, CO, NOx, methane (CH4), and nitrous oxide (N2O) from a tall tower (112 m
Understanding the dynamics of post-fire carbon recovery is critical for managing boreal forests under climate change. This study evaluates the LPJ-GUESS-BLAZE models’ performance in simulating vegetation structure, fire emissions, and post-fire carbon dynamics at the stand scale in a boreal forest in Sweden. Combining current climate and future scenarios (SSP1–2.6, SSP5–8.5), we investigated the i
Dynamisk motorisk talbedömning, DYMTA, är ett test som används för bedömning av talstörning, särskilt vid misstanke om motoriska talsvårigheter. DYMTAs dynamiska testmetod innebär att logopeden ger stöd och ledtrådar under bedömningen för att få en uppfattning om individens maximala förmåga. Yttre tecken ger information som kan härledas till grundorsaker, tex talplaneringssvårigheter.
High variability in stem cell research is a well-known limiting phenomenon, with technical variation across experiments and laboratories often surpassing variation caused by genotypic effects of induced pluripotent stem cell (iPSC) lines. Evaluation of kidney organoid protocols and culture conditions across laboratories remains scarce in the literature. We used the original air-medium interface pr
Sufficiently strong and long-lasting first-order phase transitions can produce primordial black holes (PBHs) that contribute substantially to the dark matter abundance of the Universe, and can produce large-scale primordial magnetic fields. We study these mechanisms in a generic class of conformal U(1)'models that also explain active neutrino oscillation data via the type-I seesaw mechanism. We fi
The European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) have collaborated to produce these post-resuscitation care guidelines for adults, which are based on the International Consensus on Cardiopulmonary Resuscitation Science with Treatment Recommendations (CoSTR) pubished by the International Liaison Committee on Resuscitation (ILCOR). The topics cover
These European Resuscitation Council Guidelines 2025 on epidemiology of resuscitation provides key information about incidence, patients’ characteristics, system organisation and outcomes for both out-of-hospital and in-hospital cardiac arrest in Europe and beyond. Information regarding patients’ post survival experience and causes of cardiac arrest, including genetic factors, are also reported. R
Adaptive network dynamical systems describe the co-evolution of dynamical quantities on the nodes and the dynamics of the network connections themselves. For dense networks of many nodes, the resulting dynamics are typically high-dimensional. Here, we consider adaptive dynamical systems subject to constraints on network adaptation: Asymptotically, the adaptive dynamics of network connections evolv
This paper presents the results from a qualitative study with Swedish researchers in the social sciences and the humanities. The aim of the study was to explore researchers’ perceptions of ethical review (i.e. the pros and cons of the system) and to what extent the system of ethical review could possibly be reformed to better accommodate research in the social sciences and the humanities. To this
Diabetic kidney disease (DKD) is a health burden that lacks specific and early diagnostic biomarkers. For their discovery, we sequenced urinary extracellular vesicle miRNAs in a type 1 diabetes cohort of males with and without DKD. The results were replicated by sequencing or qPCR in two independent cohorts and six published datasets, including type 1 and 2 diabetes, and both sexes. We also valida
Climate warming is expected to influence the prevalence of vector-transmitted parasites. Understanding the extent to which this is ongoing, or has already occurred, requires empirical data from populations monitored over long periods of time, but these studies are sparse. Further, vector-disease research involving human health is often influenced by disease control efforts that supersede natural t
The efficient computation of color-summed QCD amplitudes at high parton multiplicities remains a central challenge for precision collider predictions. Existing approaches using trace, color-flow, or adjoint bases suffer from non-orthogonality, which complicates the color algebra and scales poorly with multiplicity. In this work, we present an off-shell recursive framework for computing all-gluon t
