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Transient Flow and Heat Transfer in a Horizontal Rectangular Channel Considering Thermal-Fluid-Structure Interaction

For the supercritical n-decane horizontally flowing in a rectangular channel of an active regenerative cooling system, a transient thermal-fluid-structure coupling method is employed to investigate the unsteady thermal-hydraulic characteristics and the wall deformation at a starting stage. The temperature distributions of the fluid domain and solid domain along the flow direction are investigated

Dynamics-Based Optimal Motion Planning of Multiple Lane Changes using Segmentation

Avoidance maneuvers at normal driving speed or higher are demanding driving situations that force the vehicle to the limit of tire–road friction in critical situations. To study and develop control for these situations, dynamic optimization has been in growing use in research. One idea to handle such optimization computations effectively is to divide the total maneuver into a sequence of sub-maneu

Mutation Testing: Fewer, Faster, and Smarter

Ökat användande av testautomation föranleder en grundläggande fråga: Hur tillförlitliga är egentligen alla dessa automatiserade tester? Inom den akademiska forskningen anses mutationstestning vara den mest lovande tekniken för att bedöma en testsvits förmågas att upptäcka fel. Tekniken introducerar avsiktligt fel (så kallade mutanter) i produktionskoden och utvärderar hur många av felen som upptäcThe growing reliance on automated software tests raises a fundamental question: How trustworthy are these automated tests? Today, mutation testing is acknowledged within academic circles as the most promising technique for assessing the fault-detection capability of a test suite. The technique deliberately injects faults (called mutants) into the production code and counts how many of them are cau

Prevalence of mental health problems, associated factors, and health-related quality of life in children with long-gap esophageal atresia in Sweden

Background: Children with long-gap esophageal atresia (LGEA) face a high risk of digestive and respiratory morbidity, but their mental health outcomes have not been investigated. We aimed to identify the prevalence of mental health problems in children with LGEA, associated factors and health-related quality of life (HRQOL). Methods: Twenty-six children with LGEA aged 3–17 were recruited nationwid

Investigating Partially Discordant Results in Phase 3 Studies of Aducanumab

Objectives: Efficacy and safety results from the EMERGE (NCT02484547) and ENGAGE (NCT02477800) phase 3 studies of aducanumab in early Alzheimer’s disease (AD) have been published. In EMERGE, but not in ENGAGE, high-dose aducanumab demonstrated significant treatment effects across primary and secondary endpoints. Low-dose aducanumab results were consistent across studies with non-significant differ

An experimental and theoretical investigation on Ti-5553/WC–Co(6%) chemical interactions during machining and in diffusion couples

Chemical interactions that drive crater wear in turning are often studied using diffusion couples where the tool and workpiece are fixed. In contrast, in actual turning, there is a constant supply of new workpiece material at the tool-chip interface. In this work, diffusion simulations of a WC–Co(6%) and Ti–5Al–5V system were conducted, with constant replenishment of titanium at the interface (ope