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Comparison of Static and Ambulatory Measurements of Illuminance and Spectral Composition That Can Be Used for Assessing Light Exposure in Real Working Environments

Reliable measurements are of utmost importance when investigating the relationship between light and human reactions. The aim of the present study was to compare two methods for measuring light exposure in real working environments. Ambulatory recordings of illuminance and irradiance were compared with static field measurements of horizontal illuminance at the normal working position, average hori

An alternative biomarker-based approach for the prediction of proteins known to sensitize the respiratory tract

Many natural and industrial proteins are known to have properties that can result in type I hypersensitivity, however, to date, no validated test system exists that can predict the sensitizing potential of these allergens. Thus, the objective of this study was to develop a protocol based on the myeloid cell-based Genomic Allergen Rapid Detection (GARD) assay that can be used to assess and predict

Increasing the density of modes in an optical frequency comb by cascaded four-wave mixing in a nonlinear optical fiber

Here, it is shown that when two optical frequency combs with identical mode spacing but different offset frequencies copropagate through a nonlinear optical fiber, four-wave mixing between them generates new modes. Although the spacings between the new modes depend on the difference of the offset frequencies, they appear irregular because of the large number of possible four-wave-mixing processes.

Methods in field chronobiology

Chronobiological research has seen a continuous development of novel approaches and techniques to measure rhythmicity at different levels of biological organization from locomotor activity (e.g. migratory restlessness) to physiology (e.g. temperature and hormone rhythms, and relatively recently also in genes, proteins and metabolites). However, the methodological advancements in this field have be

How Energy Metabolism Supports Cerebral Function : Insights from (13)C Magnetic Resonance Studies In vivo

Cerebral function is associated with exceptionally high metabolic activity, and requires continuous supply of oxygen and nutrients from the blood stream. Since the mid-twentieth century the idea that brain energy metabolism is coupled to neuronal activity has emerged, and a number of studies supported this hypothesis. Moreover, brain energy metabolism was demonstrated to be compartmentalized in ne

Compartmentalized Cerebral Metabolism of [1,6-(13)C]Glucose Determined by in vivo (13)C NMR Spectroscopy at 14.1 T

Cerebral metabolism is compartmentalized between neurons and glia. Although glial glycolysis is thought to largely sustain the energetic requirements of neurotransmission while oxidative metabolism takes place mainly in neurons, this hypothesis is matter of debate. The compartmentalization of cerebral metabolic fluxes can be determined by (13)C nuclear magnetic resonance (NMR) spectroscopy upon in

Glutamatergic and GABAergic energy metabolism measured in the rat brain by (13) C NMR spectroscopy at 14.1 T

Energy metabolism supports both inhibitory and excitatory neurotransmission processes. This study investigated the specific contribution of astrocytic metabolism to γ-aminobutyric acid (GABA) synthesis and inhibitory GABAergic neurotransmission that remained to be ilucidated in vivo. Therefore, we measured (13)C incorporation into brain metabolites by dynamic (13)C nuclear magnetic resonance spect

Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats

Type 1 diabetes can affect hippocampal function triggering cognitive impairment through unknown mechanisms. Caffeine consumption prevents hippocampal degeneration and memory dysfunction upon different insults and is also known to affect peripheral glucose metabolism. Thus we now characterized glucose transport and the neurochemical profile in the hippocampus of streptozotocin-induced diabetic rats

Metabolic disturbances in diseases with neurological involvement

Degeneration of specific neuronal populations and progressive nervous system dysfunction characterize neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. These findings are also reported in inherited diseases such as phenylketonuria and glutaric aciduria type I. The involvement of mitochondrial dysfunction in these diseases was reported, elicited by genetic alteratio

Activated protein C resistance caused by a common factor V mutation has a single origin

A point mutation (FV:R506Q) in the human coagulation factor V gene is associated with resistance to activated protein C and life-long increased risk of venous thrombosis. The mutation is common in populations of Caucasian origin but virtually absent among other populations. In this study of 140 healthy Swedish volunteers and 110 homozygotes for the FV:R506Q mutation, we determined the allele frequ

Properties of the cysteine-less Pho84 phosphate transporter of Saccharomyces cerevisiae

The derepressible Pho84 high-affinity phosphate permease of Saccharomyces cerevisiae, encoded by the PHO84 gene belongs to a family of phosphate:proton symporters (PHS). The protein contains 12 native cysteine residues of which five are predicted to be located in putative transmembrane regions III, VI, VIII, IX, and X, and the remaining seven in the hydrophilic domains of the protein. Here we repo

Fantasy as a driving force : relations between fantasy and motivation in children

The relationship between children’s fantasy involvement and motivational style atschool was investigated. Participants were 95 Swedish children in third to fifth grade (9–11 years). Fantasy involvement was measured with the Children’s Fantasy Inventory and motivation in the classroom was measured with the Goal Orientation Scales. Results revealed that being highly imaginative was related to higher

Human Trafficking and Forced Labour : A Criticism of the International Labour Organisation

PurposeDuring the last ten years, the International Labour Organisation (ILO), and some other international organizations, have increasingly addressed human trafficking from a “forced labour” perspective. The purpose of this paper is to clarify the terminology in relation to human trafficking and forced labour, to highlight the links between them, and to provide a critique of the ILO approach. It

Spaces of identity in the city : Embracing the contradictions

Several studies demonstrate the value of residents’ voices in the place branding process, however, relatively little is known about how residents experience participating in place branding campaigns and the consequences for place identity. This chapter explores the question of whether participatory branding initiatives could potentially lead to more inclusionary representational spaces in the city

Can a teachable agent influence how students respond to competition in an educational game?

Learning in educational games is often associated with some form of competition. We investigated how students responded to winning or losing in an educational math game, with respect to playing with or without a Teachable Agent (TA). Students could choose between game modes in which the TA took a more passive or active role, or let the TA play a game entirely on its own. Based on the data logs fro

Structural transformation and agrarian change in India

The landlord and his emaciated labourer are symbolic of Indian agriculture. However, this relationship is less assured as large landowners have fallen from their superior position. This volume explores how this emblematic pair is becoming a thing of the past. Structural Transformation and Agrarian Change in India investigates whether family labour farms are gaining prominence as a consequence of t