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By definition, radiofrequency (RF) pulses are the pivotal elements of NMR pulse sequences. Vice versa, the effect of a particular pulse on the evolution of magnetization will depend on the context of the sequence. While the product operator formalism provides a general framework to describe the effect of hard pulses on weakly coupled spin systems, there is no consistent framework describing the ef

Prostate cancer risk SNP rs10993994 is a trans-eQTL for SNHG11 mediated through MSMB

How genome-wide association studies-identified single-nucleotide polymorphisms (SNPs) affect remote genes remains unknown. Expression quantitative trait locus (eQTL) association meta-analysis on 496 prostate tumor and 602 normal prostate samples with 117 SNPs revealed novel cis-eQTLs and trans-eQTLs. Mediation testing and colocalization analysis demonstrate that MSMB is a cis-acting mediator for S

Strategy for Disease Diagnosis, Progression Prediction, Risk Group Stratification and Treatment—Case of COVID-19

A novel strategy is presented for reliable diagnosis and progression prediction of diseases with special attention to COVID-19 pandemic. A plan is presented for how the model can be implemented worldwide in healthcare and how novel treatments and targets can be detected. The idea is based on poikilosis, pervasive heterogeneity, and variation at all levels, systems, and mechanisms. Poikilosis in di

Acute reduction of cerebrospinal fluid volume prior to spinal anesthesia : implications for sensory block extent

BACKGROUND: Multiple patient and clinical characteristics contribute to the variable outcome of spinal anesthesia (SPA). Acute reduction of cerebrospinal fluid (CSF) volume may alter the effect of SPA. The objective of the present study was to test if aspiration of 10 mL CSF immediately prior to SPA is associated with higher extent of sensory block. METHODS: Interventional cohort study. One hundre

Tracing KEGR

As a researcher, I have spent countless hours hunting for tags. Recently, I started thinking about ways to represent not just my physical search, but also the thought process taking place alongside the visible bodily activities: remembering – for example – the style, medium, size and placement of previous tags of interest in order to better spot similar tags and their likely locations.This video i

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The treatment of rheumatoid arthritis is currently based on pathogenesis and pathophysiology, being the etiology still unknown. At cognition and activation phase of rheumatoid arthritis, there is a number of potential therapeutic approaches, still in development and in early trials. At inflammation and even more at invasive phase of rheumatoid arthritis, the treatment should take into consideratio

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The study has been performed in order to give a contribution to the knowledge of the conjunctival cytology in Sjögren's syndrome. Exfoliated cells were obtained by a tampon from the inferior conjunctival sac of 11 patients affected by primary or secondary Sjögren's syndrome; the material was placed onto a microscope slide and it was stained with May-Grumwald-Giemsa, after the ferning test had been

Berättelser om en röd stuga : Föreställningar om en idyll ur ett svenskdidaktiskt perspektiv

This licentiate-thesis, Stories About a red Cottage, is an attempt to combine cultural theory with a didactic method applied to Swedish as a field of study. With the two notions intertextuality and the foreign as a starting point, I discuss the importance of how an idyllic view of Sweden affects students studying Swedish as a foreign language as part of their studies in Scandinavistics. The studenThis licentiate-thesis, Stories About a red Cottage, is an attempt to combine cultural theory with a didactic method applied to Swedish as a field of study. With the two notions intertextuality and the foreign as a starting point, I discuss the importance of how an idyllic view of Sweden affects students studying Swedish as a foreign language as part of their studies in Scandinavistics. The studen

Contrast sensitivity and the detection of moving patterns and features

Theories based on optimal sampling by the retina have been widely applied to visual ecology at the level of the optics of the eye, supported by visual behaviour. This leads to speculation about the additional processing that must lie in between-in the brain itself. But fewer studies have adopted a quantitative approach to evaluating the detectability of specific features in these neural pathways.

Evolutionary consequences of multidriver environmental change in an aquatic primary producer

Climate change is altering aquatic environments in a complex way, and simultaneous shifts in many properties will drive evolutionary responses in primary producers at the base of both freshwater and marine ecosystems. So far, evolutionary studies have shown how changes in environmental drivers, either alone or in pairs, affect the evolution of growth and other traits in primary producers. Here, we

Dikter av Kathleen Jamie

8 poems by Scottish poet Kathleen Jamie (b. 1962) in translation from English of Lars Gustaf Andersson, with a brief commentary.

Thumb Base Osteoarthritis: Prevalence, Occupational Risk, and Surgical Outcomes

Osteoarthritis of the carpometacarpal joint at the base of the thumb (CMC1 OA) is common and causes difficulty in grasp, grip, and fine manipulation of the hand. Surgery is recommended after failure of non-operative treatment, andevidence from short and medium-term follow-up studies shows successful relief of pain and return of function. Previous investigations of epidemiology and risk factors wer