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Myoepithelioma of bone with a novel FUS-POU5F1 fusion gene

AimsMyoepithelial tumours of soft tissue are rare lesions with a broad morphological and clinical spectrum. Previous studies have found EWSR1 rearrangements in approximately half of all cases and PBX1, ZNF44 and POU5F1 have been identified as recurrent fusion partners. In bone, only a small number of myoepithelial tumours have been described. We investigated an intraosseous myoepithelioma of the s

Species recognition through wing interference patterns (WIPs) in Achrysocharoides Girault (Hymenoptera, Eulophidae) including two new species

Wing interference patterns (WIPs) are shown to be an important tool for species recognition in the genus Achrysocharoides Girault (Hymenoptera: Eulophidae). This is demonstrated by combining information from two previously published papers, comprising two cases of cryptic species, and by new material including the description of two new species, A. maieri and A. serotinae from North America. The c

Does Low-Molecular-Weight Heparin Influence the Antimyeloma Effects of Thalidomide? A Retrospective Analysis of Data from the GIMEMA, Nordic and Turkish Myeloma Study Groups

Background/Aim: Low-molecular-weight heparin (LMWH) has been shown to prolong survival among patients with solid tumors, but its role among myeloma patients is unknown. Patients: Data from the GIMEMA (Gruppo Italiano Malattie Ematologiche dell'Adulto), Nordic and Turkish myeloma study groups comparing melphalan and prednisolone with (MPT, n: 404) or without thalidomide (MP, n: 393) are analyzed fo

Anisotropic dynamic changes in the pore network structure, fluid diffusion and fluid flow in articular cartilage under compression

A compression cell designed to fit inside an NMR spectrometer was used to investigate the in situ mechanical strain response, structural changes to the internal pore structure, and the diffusion and flow of interstitial water in full-thickness cartilage samples as it was deforming dynamically under a constant compressive load (pressure). We distinguish between the hydrostatic pressure acting on th

An atlas of G-protein coupled receptor expression and function in human subcutaneous adipose tissue.

G-protein coupled receptors (GPCRs) are involved in the regulation of adipose tissue function, but the total number of GPCRs expressed by human subcutaneous adipose tissue, as well as their function and interactions with drugs, is poorly understood. We have constructed an atlas of all GPCRs expressed by human subcutaneous adipose tissue: the 'adipose tissue GPCRome', to support the exploration of

A fundamental view of enthalpy-entropy compensation

In this paper, enthalpy-entropy compensation (EEC) during the association of two molecules is studied by minimising model systems with molecular mechanics (MM) or quantum mechanics (QM), calculating translational, rotational, and vibrational contributions to the enthalpy and entropy with standard statistical-mechanics methods, using the rigid-rotor harmonic-oscillator approach. We start with simpl

A coding IRAK2 variant compromises TLR signaling and is associated with colorectal cancer survival.

Within innate immune signaling pathways, Interleukin-1 receptor (IL-1R&)-associated kinases (IRAKs) fulfill key roles downstream of multiple Toll-like receptors (TLR) and the IL-1R. Whereas human IRAK4-deficiency was shown to lead to severe immunodeficiency in response to pyogenic bacterial infection during childhood, little is known about the role of human IRAK2. We here identified a non-syno

Access to Neuropsychologic Services After Pediatric Brain Tumor.

Background: Increasing survival rates for pediatric brain tumor patients creates a greater need for neuropsychologic follow-up and intervention. The aim of this study was to evaluate rates of referral by medical doctors to neuropsychologic services and patient and treatment factors that differentiated referred and non-referred patients. Methods: Data were retrieved from medical records of all pedi

Archaean andesite petrogenesis : insights from the Grædefjord Supracrustal Belt, southern West Greenland

We present new whole-rock major, trace and platinum-group element data, as well as Sm–Nd and Lu–Hfisotope data for meta-volcanic rocks from the Mesoarchaean Grædefjord Supracrustal Belt (GSB), locatedwithin the Tasiusarsuaq terrane, southern West Greenland. We also present new in situ zircon U–Pbisotope data (by LA-ICP-MS) for associated felsic rocks. This region has experienced amphibolite to low

Second malignant neoplasms in digestive organs after childhood cancer: a cohort-nested case-control study

Purpose: Cancers of the digestive system constitute a major risk for childhood cancer survivors treated with radiotherapy once they reach adulthood. The aim of this study was to determine therapy-related risk factors for the development of a second malignancy in the digestive organs (SMDO) after a childhood cancer. Methods and Materials: Among 4,568 2-year survivors of a childhood solid cancer dia

Thrombin stimulates insulin secretion via protease-activated receptor-3.

The disease mechanisms underlying type 2 diabetes (T2D) remain poorly defined. Here we aimed to explore the pathophysiology of T2D by analyzing gene co-expression networks in human islets. Using partial correlation networks we identified a group of co-expressed genes ('module') including F2RL2 that was associated with glycated hemoglobin. F2Rl2 is a G-protein-coupled receptor (GPCR) that encodes p

SLA developmental stages and teachers’ assessment of written French: Exploring Direkt Profil as a diagnostic assessment tool

One of the core areas for research in SLA is the identification and definition of developmental stages in different L2s. For French, Bartning and Schlyter (2004) presented a model of six morphosyntactic stages of development, which was later implemented in the computer program Direkt Profil (Granfeldt et al. 2006). Despite the potential importance of such results, research on developmental stages

Establishing sustainability science in higher education institutions: towards an integration of academic development, institutionalization, and stakeholder collaborations

The field of sustainability science aims to understand the complex and dynamic interactions between natural and human systems in order to transform and develop these in a sustainable manner. As sustainability problems cut across diverse academic disciplines, ranging from the natural sciences to the social sciences and humanities, interdisciplinarity has become a central idea to the realm of sustai

The LEAF questionnaire: a screening tool for the identification of female athletes at risk for the female athlete triad

Background Low energy availability (EA) in female athletes with or without an eating disorder (ED) increases the risk of oligomenorrhoea/functional hypothalamic amenorrhoea and impaired bone health, a syndrome called the female athlete triad (Triad). There are validated psychometric instruments developed to detect disordered eating behaviour (DE), but no validated screening tool to detect persiste

Nonheme Fe(IV) Oxo Complexes of Two New Pentadentate Ligands and Their Hydrogen-Atom and Oxygen-Atom Transfer Reactions

Two new pentadentate {N5} donor ligands based on the N4Py (N4Py = N,N-bis(2-pyridylmethyl)-N-bis(2-pyridyl)methylamine) framework have been synthesized, viz. [N-(1-methyl-2-benzimidazolyl)methyl-N-(2-pyridyl)methyl-N-(bis-2-pyridyl methyl)amine] (L1) and [N-bis(1-methyl-2-benzimidazolyl)methyl-N-(bis-2-pyridylmethyl)amine] (L2), where one or two pyridyl arms of N4Py have been replaced by correspon