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Increase in muscle nociceptive substances and anaerobic metabolism in patients with trapezius myalgia: microdialysis in rest and during exercise

Local metabolic changes are suggested to be involved in muscle pain development in humans. Nineteen women with chronic work-related trapezius myalgia (TM) and 20 healthy female controls (CON) were studied during baseline rest, 20 min repetitive low-force exercise, and 120 min recovery. Interstitial serotonin (5-HT), glutamate, lactate, pyruvate, and blood flow were determined by microdialysis in t

Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study)

Aims/hypothesis Recent genome-wide association studies performed in selected patients and control participants have provided strong support for several new type 2 diabetes susceptibility loci. To get a better estimation of the true risk conferred by these novel loci, we tested a completely unselected population of type 2 diabetes patients from a Norwegian health survey (the HUNT study). Methods We

Determination of hyperfine-induced transition rates from observations of a planetary nebula

Observations of the planetary nebula NGC3918 made with the STIS instrument on the Hubble Space Telescope reveal the first unambiguous detection of a hyperfine-induced transition 2s2p P-3(0)o-->2s(2) S-1(0) in the berylliumlike emission line spectrum of N IV at 1487.89 Angstrom. A nebular model allows us to confirm a transition rate of 4x10(-4) sec(-1)+/-33% for this line. The measurement represent

Stability of the solutions of the Gross-Pitaevskii equation

We examine the static and dynamic stability of the solutions of the Gross-Pitaevskii equation and demonstrate the intimate connection between them. All salient features related to dynamic stability are reflected systematically in static properties. We find, for example, the obvious result that static stability always implies dynamic stability and present a simple explanation of the fact that dynam

The fragrance hand immersion study - an experimental model simulating real-life exposure for allergic contact dermatitis on the hands

Recently, we showed that 10.2% of consecutively patch-tested hand eczema patients had a positive patch test to a selection of fragrances containing fragrances relevant to hand exposure. In this study, we used repeated skin exposure to a patch test-positive fragrance allergen in patients previously diagnosed with hand eczema to explore whether immersion of fingers in a solution with or without the

Gender differences in species recognition and the evolution of asymmetric sexual isolation

Closely related sympatric species are expected to evolve strong species discrimination because of the reinforcement of mate preferences [1-4]. Fitness costs of heterospecific matings are thought to be higher in females than in males, and females are therefore expected to show stronger species discrimination than males [5, 6]. Here, we investigated gender and species differences in sexual isolation

Eyewitnesses under influence: How feedback affects the realism in confidence judgements

This study investigated the effect of two types of feedback (confirmatory and disconfirmatory) on the accuracy in witnesses' confidence judgements of their event memory. Overall, the witnesses evidenced overconfidence both when they received feedback and in the Control condition (no feedback). The results showed that confirmatory feedback caused higher overconfidence, compared both with when recei

Elderly care recipients in a swedish municipality living in their own homes and being cared for by their families; their diseases, functional health status and care provided as reported by formal carers.

The aim of this study was to investigate from the perspective of formal carers the care given to people aged 65 and over, who are cared for in their own homes by informal care. Thirty-three district nurses (DNs) and 20 home service assistants in a municipality with 13500 inhabitants (over 65 years old), were interviewed about the location of care recipients and 398 care recipients were located. Mo

Trisomy 7 accumulates with age in solid tumors and non-neoplastic synovia

Trisomy 7 is a common finding in benign and malignant solid tumors, in several non-neoplastic lesions (for example, osteoarthritis and rheumatoid arthritis), and in apparently normal tissues as well, suggesting that the occurrence of +7 might be associated with factors other than the disease process itself. To find out whether the frequency of +7 varies with a patient's age, we cytogenetically ana

Determination of glutamic acid decarboxylase antibodies (GADA) IgG subclasses - comparison of three immunoprecipitation assays (IPAs)

IgG subclasses of glutamic acid decarboxylase (GAD(65)) antibodies (GADA) may reflect the immunological state in the pancreas of GADA-positive patients with autoimmune diabetes. The use of biotin-conjugated antibodies and streptavidin Sepharose are used commonly in immunoprecipitation assays (IPA) based on (125)I- or (35)S-labelled antigens to capture IgG subclasses directed against IA-2 or GAD(65

Clinical-scale generation of strongly CD83-expressing dendritic cells using extracorporeal photopheresis

Background: Many strategies are currently being pursued in order to generate mature dendritic cells (DC) to be used for immunotherapy. A potent anti-tumour influence by extracorporeal photopheresis has been documented for cutaneous T-cell lymphoma, and a major mechanism of action has been suggested to be generation of DC presenting tumour antigens. Purpose: To determine the potential of a simple c

Widespread changes in neurotransmitter expression and number of enteric neurons and interstitial cells of Cajal in lethal spotted mice: an explanation for persisting dysmotility after operation for Hirschsprung's disease?

Gastrointestinal motor dysfunction persists in a large number of children subjected to surgical treatment for Hirschsprung's disease, indicating abnormalities in the remaining intestine. The aim of the study was to detect possible alterations in frequency and topographic distribution of enteric neurons and interstitial cells of Cajal in an experimental model (the lethal spotted mouse displaying a

Paediatric care of the child with haemophilia.

The paediatric care of children with haemophilia in developed countries should focus on the health of the child, not on the disorder. Gene therapy offers the hope of an ultimate 'cure' for the disorder, but until this is a viable proposition, patients should be given more control over their treatment, and the focus should be on 'self-monitored and self-adjusted' prophylaxis. New instruments for me

A rheological investigation of the complex formation between hydrophobically modified ethyl (hydroxy ethyl) cellulose and cyclodextrin

The thickening effect of a hydrophobically modified polymer in an aqueous solution is dependent on intermolecular hydrophobic associations, and if the polymer concentration is significantly above the overlap concentration also on chain entanglements. In this investigation we have added different cyclodextrins (CD) in order to decouple hydrophobic polymer-polymer associations via inclusion complex

Enrichment of membrane proteins by partitioning in detergent/polymer aqueous two-phase systems.

Methods that combine efficient solubilization with enrichment of proteins and intact protein complexes are of central interest in current membrane proteomics. We have developed methods based on nondenaturing detergent extraction of yeast mitochondrial membrane proteins followed by enrichment of hydrophobic proteins in aqueous two-phase system. Combining the zwitterionic detergent Zwittergent 3-10

Changes in the carbon cycle during the last deglaciation as indicated by the comparison of Be-10 and C-14 records

The variations in atmospheric radiocarbon (C-14) concentration during the last 50 000 years can be attributed to changes in the C-14 production rate (due to changes in solar activity, the geomagnetic field and/or interstellar galactic cosmic ray flux) and to changes in the global carbon cycle. The relative contributions of these processes is the subject of current debate. Although the discrepancie