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The role of the transient receptor potential (TRP) superfamily of cation-selective channels in the management of the overactive bladder

center dot The transient receptor potential (TRP) channel superfamily has been shown to be involved in nociception and mechanosensory transduction in various organ systems, and studies of the LUT have indicated that several TRP channels, including TRPV1, TRPV2, TRPV4, TRPM8, and TRPA1, are expressed in the bladder, and may act as sensors of stretch and/or chemical irritation. center dot However, t

Factors influencing the decision to extend working life or retire

Objective The aim of this study was to evaluate factors within nine identified areas that influence why some older workers want to (or believe they can) work until age 65 years or beyond, whereas others leave the workforce earlier. Methods The questionnaire-based, cross-sectional study included 1792 respondents aged 55-64 years, employed in the healthcare sector in Sweden. Using logistic regressio

Voice onset time and global foreign accent in German-French simultaneous bilinguals during adulthood

Aims and objectives: In this study, we investigated crosslinguistic influence in the phonetic systems of simultaneous bilinguals (2L1s) during adulthood. Methodology: Specifically, we analyzed the voice onset time (VOT) of the voiceless stop /k/ in the spontaneous speech of 14 German–French bilinguals who grew up in France or Germany. We looked at both languages, first comparing the groups, second

Characterization of long-term motor deficits in the 6-OHDA model of Parkinson's disease in the common marmoset.

Research aimed at developing new therapies for Parkinson's disease (PD) critically depend on valid animal models of the disease that allows for repeated testing of motor disabilities over extended time periods. We here present an extensive characterization of a wide range of motor symptoms in the 6-OHDA marmoset model of PD when tested over several months. The severity of motor deficits was quanti

Investigating the effects of the QCD dynamics in the neutrino absorption by the Earth's interior at ultrahigh energies

The opacity of the Earth to incident ultrahigh energy neutrinos is directly connected with the behavior of the neutrino-nucleon (sigma(nu N)) cross sections in a kinematic range utterly unexplored. In this work we investigate how the uncertainties in sigma(nu N) due the different QCD dynamic models modify the neutrino absorption while they travel across the Earth. In particular, we compare the pre

Charge regulation in biomolecular solution.

Proteins and other biomolecules contain acidic and basic titratable groups that give rise to intricate charge distributions and control electrostatic interactions. 'Charge regulation' concerns how the proton equilibria of these sites are perturbed when approached by alien molecular matter such as other proteins, surfaces and membranes, DNA, polyelectrolytes etc. Importantly, this perturbation gene

Knock down of GAD67 protein levels normalizes neuronal activity in a rat model of Parkinson's disease.

BACKGROUND: Dopamine depletion of the striatum is one of the hallmarks of Parkinson's disease. The loss of dopamine upregulates GAD67 expression in the striatal projection neurons and causes other changes in the activity of the basal ganglia circuit. METHODS: To normalize the GAD67 expression in the striatum after dopamine depletion we developed several lentiviral vectors that express RNAi directe

V-Dem: A New Way to Measure Democracy

In the last few decades, Western governments have spent huge sums of money to promote democracy abroad. We do not know which, if any, of these programs actually work. If we cannot measure democracy in sufficient detail and with the necessary nuance, we cannot mark its progress and setbacks or affect its future course. While distinguishing the most democratic countries from the least democratic one

An Analysis of 1/f Noise to Phase Noise Conversion in CMOS Harmonic Oscillators

We present a study of tail-bias-current 1/f noise upconversion into 1/f(3) phase noise for both CMOS Colpitts and differential-pair LC oscillators. We focus on the incremental Groszkowski effect, i.e., the modulation of the shift in oscillation frequency induced by the higher current harmonics flowing into the LC tank of a harmonic oscillator induced by bias instabilities, as we show that there is

The Loss of Aroma Components of the Fruit of Vangueria infausta L. (African Medlar) After Convective Drying

The loss of aroma components after drying the fruit of Vangueria infausta L. was studied by means of convective air drying and gas chromatography techniques. The samples were dried at 80 degrees C, with an air flow of 3m/s at different drying times in the range of 60 up to 420min. Aroma composition, dry matter, and water activity were measured for each sample throughout the drying time. The study

Therapeutic Hypothermia in Children and Adults with Severe Traumatic Brain Injury.

Great expectations have been raised about neuroprotection of therapeutic hypothermia in patients with traumatic brain injury (TBI) by analogy with its effects after heart arrest, neonatal asphyxia, and drowning in cold water. The aim of this study is to review our present knowledge of the effect of therapeutic hypothermia on outcome in children and adults with severe TBI. A literature search for r

A critical appraisal of the evidence for using cardiotocography plus ECG ST interval analysis for fetal surveillance in labor. Part II: the meta-analyses.

We appraised the methodology, execution and quality of the five published meta-analyses that are based on the five randomized controlled trials (RCTs) which compared cardiotocography (CTG) +ST analysis to CTG. The meta-analyses contained errors, either created de novo in handling of original data, or from a failure to recognize essential differences among the RCTs, particularly in their inclusion

Clinically Relevant Depressive Symptoms in Young Stroke Patients - Results of the sifap1 Study

Background: Although post-stroke depression is widely recognized, less is known about depressive symptoms in the acute stage of stroke and especially in young stroke patients. We thus investigated depressive symptoms and their determinants in such a cohort. Methods:The Stroke in Young Fabry Patients study (sifap1) prospectively recruited a large multinational European cohort (n = 5,023) of patient

Stroke Prevalence, Mortality and Disability-Adjusted Life Years in Adults Aged 20-64 Years in 1990-2013: Data from the Global Burden of Disease 2013 Study

Background: Recent evidence suggests that stroke is increasing as a cause of morbidity and mortality in younger adults, where it carries particular significance for working individuals. Accurate and up-to-date estimates of stroke burden are important for planning stroke prevention and management in younger adults. Objectives: This study aims to estimate prevalence, mortality and disability-adjuste

Treatment patterns with topicals, traditional systemics and biologics in psoriasis - a Swedish database analysis

BackgroundLittle data exist on real-world treatment patterns in psoriasis, especially from European settings. ObjectiveTo estimate, for topicals, systemics and biologics, the time to non-persistency, switching, augmentation and insufficient treatment result (only for biologics), as well as to estimate the time to restart, in patients treated with each treatment class in Sweden based on registry da