An appropriate production of mature blood cells, or hematopoiesis, is essential for organismal health and homeostasis. In this developmental cascade, hematopoietic stem cells (HSCs) differentiate into intermediate progenitor types, that subsequently give rise to the many distinct blood cell lineages. Here, we describe tools and methods that permit for temporal and native clonal-level HSC lineage t

Cytokines are key regulators of tumor immune surveillance by controlling immune cell activity. Here, we investigated whether interleukin 4 (IL4) has antileukemic activity via immune-mediated mechanisms in an in vivo murine model of acute myeloid leukemia driven by the MLL-AF9 fusion gene. Although IL4 strongly inhibited leukemia development in immunocompetent mice, the effect was diminished in imm

Background: Preclinical rodent models for Parkinson's disease (PD) based on viral human alpha-synuclein (h-αSyn) overexpression recapitulate some of the pathological hallmarks as it presents in humans, such as progressive cell loss and additional synucleinopathy in cortical and subcortical structures. Recent studies have combined viral vector-based overexpression of human wild-type αSyn with the s

BACKGROUND: Cognitive impairment is a serious comorbidity in heart failure patients, but effective therapies are lacking. We investigated the mechanisms that alter hippocampal neurons following myocardial infarction (MI).METHODS: MI was induced in male C57Bl/6 mice by left anterior descending coronary artery ligation. We utilised standard procedures to measure cystic fibrosis transmembrane regulat

Background: There are few studies on the locus coeruleus (LC) in frontotemporal lobar degeneration (FTLD) and the potential differences in the LC related to the underlying proteinopathy. Objective: The aim of this study was to investigate the LC in FTLD subgroups. Methods: Neuropathological cases diagnosed with FTLD were included. The subgroups consisted of FTLD with tau, transactive response DNA-

Milk with different κ-casein (CN) phenotypes has previously been found to influence its gastric digestion rate. Therefore, the aim of the present study is to disentangle contributions of genetic variation and its related sialylation on the in vitro digestion process of κ-CN. Accordingly, κ-CN was purified from milk representing homozygous cows with κ-CN phenotypes AA, BB, or EE and used as substra

The coronavirus disease 2019 (COVID-19) pandemic has challenged an array of democratic institutions in complex and unprecedented ways. Little academic work, however, has considered the pandemic’s impact on Canada’s courts. This article aims to partially fill that gap by exploring the Canadian court system’s response to COVID-19 and the prospects for administering justice amid disasters, all throug

Generally, droplet velocity in liquid-liquid two-phase flow in microchannel is obtained via droplet displacement and time interval precise determination in sequential photos/videos. The precision is tightly related to shutter speed of the camera. In this paper, a novel method called direct image method is proposed to predict the droplet velocity. The droplet velocity can be easily obtained in one

Evaluating soil strength by geophysical methods using P-waves was undertaken in this study to assess the effects of changed binder ratios on stabilization and compression characteristics. The materials included dredged sediments collected in the seabed of Timrå region, north Sweden. The Portland cement (Basement CEM II/A-V, SS EN 197-1) and ground granulated blast furnace slag (GGBFS) were used as

This chapter examines the complex relationship between social enterprises and taxation. The focus is not on a specific country, although various examples are mentioned. As specific tax measures for social enterprises are a form of tax incentives, the chapter discusses this public finance concept. In addition, an important legal constraint on introducing such incentives for social enterprises in th

This article shows that visual representations are valuable sources for investigating the cultural and social history of the humankind-nature relationship. It does so by considering visual representations of future acts of environing as technologies that, connoting the making of the environment, disclose societal sensibilities and actors’ agendas regarding technology, the environment and nature. B

Fatal intoxications with opioids are known to be associated with an increased lung weight, as well as with brain and pulmonary edema and urinary retention. However, there is evidence to suggest that fatal intoxications with non-opioid substances are also associated with increased lung weight; however, the latter aspect has not been comprehensively analyzed. To determine to what extent opioid and n

Objective: To assess women's perceptions of the quality of maternal and newborn care (QMNC) received in hospitals in Romania during the COVID-19 pandemic by mode of birth. Methods: A validated anonymous online questionnaire based on WHO quality measures. Subgroup analysis of spontaneous vaginal birth (SVB), emergency cesarean, and elective cesarean and multivariate analyses were performed, and QMN

Objective: To explore quality of maternal and newborn care (QMNC) in healthcare facilities during the COVID-19 pandemic in Switzerland. Methods: Women giving birth in Switzerland answered a validated online questionnaire including 40 WHO standards-based quality measures. QMNC score was calculated according to linguistic region and mode of birth. Differences were assessed using logistic regression

Many bird species typical to farmland have declined in numbers in recent decades. Some farmland bird species occur outside farmland in other open man-made habitats, such as forest clear-cuts. Given that in Sweden the total area of clear-cuts (5–6 %) almost equals that of farmland (8 %), clear-cuts have the potential to be an important habitat for some farmland birds. We investigated how bird commu

Corruption has become, without a doubt, a buzzword in both academic and policy debates over the last three decades. The initial view that “corruption greases the wheels of economic growth” in the newly independent states of Africa and Asia has lost its validity in light of the current and ever-growing global coalition against corruption, spearheaded by Transparency International (TI) and the World

In recent years, several countries have started to introduce 2 + 1 roads into their road networks. Although some studies have recognized the great benefits of using 2 + 1 roads, few studies have investigated the effects of different design features of 2 + 1 roads on driver behavior and driving performance, including the type of median separation between opposing traffic flows. The overall aim of t

PurposeTo determine the association between the occurrence of sporadic and periodic fetal heart rate accelerations during labor and acidemia at birth.Materials and methodsThis is a case–control study of fetal heart rate patterns from 364 neonates with acidemia at birth (cord blood pH ResultsDuring the first stage, ≥2 sporadic accelerations were present in 16% of cases and 78% of controls; OR for a