A method has been developed that automatically constructs a crystallographic refinement force field (topology and parameter files) for any molecule from a theoretical frequency calculation. The approach has been tested on five proteins containing metal sites or non-standard inhibitors or coenzymes and it is shown that the structures are improved in various aspects.

The aim Of this Study was to determine the effects of dexamethasone (Dex) and alpha-ketoglutarate (AKG) oil the total cholesterol, glucose, Na+, Cl-, total Ca and K+ levels, in serum for newborn and neonate piglets. The blood samples were collected from newborn non-suckling piglets born by sows administered front the 91(st) d of pregnancy to the parturition With AKG and/or Dex (AKG-0.4 g/kg b.w./e

A group of Swedish oncologists and hospital physicists have estimated the number of patients in Sweden suitable for proton beam therapy. The estimations have been based on current statistics of tumour incidence, number of patients potentially eligible for radiation treatment, scientific support from clinical trials and model dose planning studies and knowledge of the dose-response relations of dif

Popular Abstract in Swedish "Dom säjer de - do - dopey Swedes - but I tell you that - dom e inte så dopia" Avhandlingen beskriver språket som talas av den sista generationen svenska utvandrare till Nordamerika. Inflytandet från engelskan gör sig gällande på olika sätt, t.ex. som codeswitching, där ord eller fraser från engelskan används oförändrade ("dopey Swedes", "but I tell you that"), eller This thesis concerns two languages in contact: English and Swedish. It is based on interviews with Swedes who came to North America with the last major wave of emigration. The bilingual phenomena that appear in their speech, ranging from codeswitching to morphological, structural and semantic transfer, are considered as forming a continuum of language alternation. The study explores the opposing

I denna rapport ges några bilder av ekonomen i Sveriges kommuner och landsting. Förhoppningen är att dessa bilder bl.a. kan ge ett bidrag till de egenskaper och roller som tilldelas sektorns ekonomer. Bilderna förmedlas av den volymmässigt största andelen av sektorns ekonomer, d.v.s. de ekonomer som kan sägas vara underordnade en ekonomichef eller förvaltningschef. En fjärdedel av de nästan 600 ek

Background: The association between nasal and bronchial symptoms, and the course of bronchial responsiveness and airway inflammation in house dust mite sensitive persistent rhinitis over a prolonged time period has not been thoroughly explored. Objective: To determine if nasal symptoms were associated with bronchial symptoms in persistent rhinitic subjects, and to assess their bronchial responsive

We present statistical evaluations of wideband spatial dual-polarized radio channel measurements. Some 80 different street-level transmitter positions in downtown Helsinki, Finland, were measured. We chose three different receiver array sites below, at, and above the roofop level of the surrounding urban environment. A super-resolution algorithm allows the determination of the directions of arriva

Free radicals have recently been proposed to play a role in the development of diabetic retinopathy. The aim of the present study was to examine whether the abnormal metabolism caused by diabetes and by ischemia followed by recirculation interferes with a free radical enzyme defense system in the retina, ie, glutathione. Diabetes mellitus was induced by injecting streptozotocin ([STZ] 60 mg/kg bod

On the origin, use and dating of the customary of the cathedral chapter of Lund, i.e. the Consuetudines Lundenses. I have argued that the consuetudines were used by the canons from 30 June 1123 at the latest, the day of inauguration of the crypt church. This seems even more plausible as the prototype of the text, i.e. the Consuetudines Marbacenses, were recently antedated. Furthermore, these circu

In this paper, the further development of a silicon flowthrough microdispenser is described. Previously reported designs of the dispenser used bimorph, and later multilayered, piezoelectric actuator elements for the generation of droplets. The introduction of a multilayered actuator significantly reduced the voltage amplitude needed to dispense droplets. Dispenser properties relevant for chemical

BACKGROUND: Studies in patients with peripheral arterial disease (PAD) have reported an association between inflammatory markers and severity of disease or worsening of symptoms. However, few have studied the prognostic significance of inflammatory markers in asymptomatic subjects, measured many years before the onset of symptomatic PAD requiring treatment (trPAD).MATERIAL AND METHODS: Five inflam

Laparoscopy and palpation offer only a rough estimate of the extent of endometriosis. Consequently, endometriosis involving the bowels and urinary tract is under-diagnosed. Bowel obstruction and retroperitoneal endometriosis with obstruction of the ureter are uncommon conditions, but awareness of them is important. Ureteric obstruction develops slowly from periureteral fibrosis and often results i

Abstract in French Opérant à 25 °C, on a étudié le comportement de la phase ternaire isotherme et de la structure des systèmes copolymère–eau–xylène amphiphiles de deux copolymères à trois blocs de poly(oxyde d'éthylène)–poly(oxyde de propylène) (PEO–PPO), (EO)4(PO)59(EO)4 et (EO)17(PO)59(EO)17. On a identifié les barrières des phases par RMN du 2H et par inspection sous de la lumière polarisée. OThe isothermal ternary phase behaviour and structure of amphiphilic copolymer-water-xylene systems was investigated for two poly(ethylene oxide)-poly(propylene oxide) (PEO-PPO) triblo k copolymers, (EO)(4)(PO)(59)(EO)(4) and (EO)(17)(PO)(59)(EO)(17), at 25degreesC. The phase boundaries were identified using H-2 NMR and inspection under polarized light. The microstructure and structural length scal

CMKLR1 (chemoattractant-like receptor 1) is a G-protein-coupled receptor implicated in cartilage and bone development and is expressed in organs like the parathyroid gland, brain, and lung. The receptor is also expressed in dendritic cells and in macrophages where it acts as a co-receptor for entry of HIV/SIV isolates into human CD4(+) cells. Recently, a protein named "chemerin" (also known as TIG