OBJECTIVE - Inflammatory mediators associated with type 1 diabetes are dilute and difficult to measure in the periphery, necessitating development of more sensitive and informative biomarkers for studying diabetogenic mechanisms, assessing preonset risk, and monitoring therapeutic interventions. RESEARCH DESIGN AND METHODS - We previously utilized a novel bioassay in which human type 1 diabetes se

The first radio frequency (RF) noise measurements on lateral nanowire metal-oxide-semiconductor field-effect transistors (MOSFETs) and a noise model are presented. We have characterized the RF noise and scattering parameters of an indium gallium arsenide (InGaAs) device. A fitted model yields extrapolated ft = 316 GHz current gain cutoff and fmax = 166 GHz maximum oscillation frequency. This devic

The chitosan and gelatine are commonly used biopolymers for the tissue engineering applications. In the previous methods for the cryogels synthesis, multistep preparation methods using toxic cross-linking agents such as glutaraldehyde are reported. Here, we present a two-step preparation method of gelatin macroporous cryogels and one-step preparation method of chitosan or gelatin cryogels. The phy

We present a microscopic model for collective effects in high multiplicity proton–proton collisions, where multiple partonic subcollisions give rise to a dense system of strings. From lattice calculations we know that QCD strings are transversely extended, and we argue that this should result in a transverse pressure and expansion, similar to the flow in a deconfined plasma. The model is implement

Jordens plattektoniska rörelser leder till tektoniska skeenden vid plattgränserna, bland annat bergskedjebildning, då berggrunden utsätts för förändringar i tryck och temperatur. Vid ändrat tryck och ändrad temperatur förändras också bergarter: de ursprungliga mineralen konsumeras i kemiska reaktioner och i stället bildas nya mineral som är stabila vid de nya fysikaliska förhållandena - en processDating of metamorphic events is crucial for the understanding and reconstruction of large-scale geological processes such as orogenesis. Zircon is one of the most commonly used minerals for dating of igneous and metamorphic events. Zircon incorporates uranium and excludes lead during crystallization, and with time the uranium decays to lead. The diffusion rates of both elements are slow, making zi

Several methods have been developed to predict effects of amino acid substitutions on protein stability. Benchmark datasets are essential for method training and testing and have numerous requirements including that the data is representative for the investigated phenomenon. Available machine learning algorithms for variant stability have all been trained with ProTherm data. We noticed a number of

The production cross sections for prompt charmed mesons D 0, D +, D ∗ + and Ds+ were measured at mid-rapidity in proton–proton collisions at a centre-of-mass energy s=7TeV with the ALICE detector at the Large Hadron Collider (LHC). D mesons were reconstructed from their decays D 0→ K -π+, D +→ K -π+π+, D ∗ +→ D 0π+, Ds++→K-K+π+, and their charge conjugates.With respect to previous measurements in

This paper examines whether or not specific forms of adaptation governance that involve city administrations and citizens can help (or hinder) creating a foundation for more sustainable climate adaptation and transformation. Based on the analysis of recurring patterns of social adaptation dilemmas (caused by the interdependencies between adaptation providers and beneficiaries), associated actor co

Objectives: Asthma and allergic diseases are the most frequent chronic diseases in childhood worldwide, and considered a burden for the affected children and their families. The diseases impose an economic burden on society if not diagnosed and treated properly and management of and these diseases are challenging for healthcare professionals. The aim of the present investigation was to assess the

The Roman historian Tacitus is not only our most important source for the Early Roman Empire, but also a literary artist second to none. His fragmentarily preserved Annales deals with the imperial rule established by the first emperor Augustus, the Julio-Claudian dynasty (AD 14 – 68). Through his scathing analyses of the consequences of autocratic government, Tacitus has established himself as an

The production of a top quark in association with a Z boson is investigated. The proton–proton collision data collected by the ATLAS experiment at the LHC in 2015 and 2016 at a centre-of-mass energy of s=13TeV are used, corresponding to an integrated luminosity of 36.1fb−1. Events containing three identified leptons (electrons and/or muons) and two jets, one of which is identified as a b-quark jet

In this paper, a distinctly subjectivist analysis of the nature of relational goodness or goodness for is proposed. Like the generic subjectivist analysis of value, the proposal is to analyse value in terms of attitudes. Specifically, the proposed analysis of goodness for appeals to a special kind of attitude: namely, so-called for-someone’s-sake attitudes. Unlike other analyses in the literature

Harmonic periods have wide applicability in industrial real-time systems. Rate monotonic (RM) is able to schedule task sets with harmonic periods up to 100% utilization. Also, if there is no release jitter and execution time variation, RM and EDF generate the same schedule for each instance of a task. As a result, all instances of a task are interfered by the same amount of workload. This property

Because the development of insulitis and diabetes is predictable in Lyp/Lyp congenic BB rats, we have characterized early islet inflammation in these rats to determine the cell subsets involved in the onset of autoimmune insulitis. Pancreas sections from prediabetic Lyp/Lyp, Lyp/+ and +/+ rats were analyzed by immunohistochemistry. We found W3/25+ cells in the exo- and endocrine tissue from all th

The MAX IV facility in Lund, Sweden, consists of two storage rings for production of synchrotron radiation, and a full-energy LINAC for top-up injections. The LINAC also delivers short high-intensity electron bunches to a short pulse facility. MAX IV was inaugurated in June 2016, and the larger 3 GeV ring has been delivering light to users since November 2016. In this thesis, the design and implem

Immunoprotection of islets using bioisolator systems permits introduction of allogeneic cells to diabetic patients without the need for immunosuppression. Using TheraCyte™ immunoisolation devices, we investigated two rat models of type 1 diabetes mellitus (T1DM), BB rats and rats made diabetic by streptozotocin (STZ) treatment. We chose to implant islets after the onset of diabetes to mimic the pr