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Quality of life in patients with resectable rectal cancer during the first 24 months following diagnosis

Aim: An increasing number of patients survive rectal cancer, resulting in more patients living with the side-effects of the treatment. Exploring quality of life before and after treatment enables follow-up and additional treatment to be adjusted to the patient's needs. The aim of the study was to describe the quality of life during the 24 months following diagnosis and to identify risk factors for

Preoperative Group Consultation Prior to Surgery for Colorectal Cancer—an Explorative Study of a New Patient Education Method

Abstract: Patients with colorectal cancer may lack information about the disease and treatment. In 2017, a group consultation before start of surgery was introduced at a university hospital in western Sweden to inform about the disease, treatment, and ongoing scientific studies. The primary aim of this study was to explore the experience of the patients attending the group consultation. Based on s

Predicting life with a permanent end colostomy : A prospective study on function, bother and acceptance

Aim: The factors that influence a patient's experience of a colostomy are not known. The aim of this study was to characterise stoma function, stoma-related bother and acceptance among patients operated for rectal cancer and to investigate if there were any preoperative personal factors with predictive impact on long-term stoma-related bother. Methods: The QoLiRECT (Quality of Life in RECTal cance

Younger age at onset of colorectal cancer is associated with increased patient's delay

Aim: This study aimed to investigate if younger age at diagnosis of colorectal cancer was associated with a diagnostic delay. The secondary objective was to evaluate if symptomatology varied with age. Method: The study population consisted of the cohorts from two prospective multicentre studies conducted in Sweden and Denmark, the QoLiRECT and QoLiCOL studies. These studies investigated the qualit

Timely access to care in the treatment of rectal cancer and the effect on quality of life

Aim: The aim of this study was to investigate if a delay in a patient's first contact with a healthcare professional, and any subsequent delay in diagnosis, affected self-assessed quality of life prior to start of treatment for rectal cancer. Method: Questionnaires were administered when patients had been informed of the diagnosis and planned treatment. The primary end-point was self-assessed qual

Patients with rectal cancer are satisfied with in-hospital communication despite insufficient information regarding treatment alternatives and potential side-effects

Aim: Patients with rectal cancer may undergo treatment such as surgery and (chemo)radiotherapy. Before treatment, patients are informed of different options and possible side-effects. The aim of the study was to evaluate the patients’ experience of communication with healthcare personnel at time of diagnosis and after one year. Method: A total of 1085 patients from Denmark and Sweden were included

Retrospective review of risk factors for surgical wound dehiscence and incisional hernia

Background: Several factors and patient characteristics influence the risk of surgical wound dehiscence and incisional hernia after midline laparotomy. The purpose of this study was to investigate whether a specified, or not specified, suture quota in the operative report affects the incidence of surgical wound complications and to describe the previously known risk factors for these complications

Designing for Existential Sustainability : The Intersection of Social Sustainability and Universal Design, explored through Social Staircases

In this article we discuss the notions of social sustainability and universal design by reflecting on a particular type of architectural element in common space, namely the “social staircases” that serve as multifunctional spaces beyond mere transportation, aiming at social interaction. Through empirical examples, including a detailed analysis of a newly built housing project in Sweden, renowned fIn this article we discuss the notions of social sustainability and universal design by reflecting on a particular type of architectural element in common space, namely the “social staircases” that serve as multifunctional spaces beyond mere transportation, aiming at social interaction. Through empirical examples, including a detailed analysis of a newly built housing project in Sweden, renowned f

Absurd Sounds : What if we applied the principles behind conspiracy theories — absurd premises followed by logical developments — to sound art?

Absurd (derived from surdus, or deaf, in Latin): that which cannot be heard or is contradictory to reason.This artistic research project questions the ways we work with sound, using a methodology derived from the absurd as a tool for innovation. The scientific roots of sound as a physical phenomenon are rarely disputed, whether by sound artists, sound designers, sound technicians, or even composer

Protocol for genomic recombineering in Yersinia ruckeri using CRISPR Cas12a coupled with the lambda Red system

Genomic manipulation of Yersinia ruckeri, a pathogen of salmonid fish species, is essential forunderstanding bacterial physiology and virulence. Here, we present a protocol for genomicrecombineering in Y. ruckeri, a species reluctant to standard genomic engineering, using CRISPRCas12a coupled with the l Red system. We describe steps for identifying protospacer guides,preparing repair template plasGenomic manipulation of Yersinia ruckeri, a pathogen of salmonid fish species, is essential for understanding bacterial physiology and virulence. Here, we present a protocol for genomic recombineering in Y. ruckeri, a species reluctant to standard genomic engineering, using CRISPR Cas12a coupled with the λ Red system. We describe steps for identifying protospacer guides, preparing repair template

Expanding the Discourse on Sustainability: Existential Sustainability

We've long focused on the green transition, discussing various systems emphasizing the technical aspects of transitioning our lives. Yet, as many people experience anxiety about climate change, other, more existential perspectives are rising to the surface. Questions such as What is a good life? becomes more pressing as we begin to feel the effects of climate change also in our part of the world.

Contractile Injection Systems and Use Thereof

The invention relates to re-engineering of a natural microbial syringe for loading of effector proteins that are not naturally found as cargo of the specific syringe. The cargo, that is one or more effector protein and proteins required for packing, can be up to 300 kDa and can be proteins such as toxins, therapeutic proteins, and gene modification tools. The re-engineering of the natural syringe

Cryo-EM structure of native human thyroglobulin

The thyroglobulin (TG) protein is essential to thyroid hormone synthesis, plays a vital role in the regulation of metabolism, development and growth and serves as intraglandular iodine storage. Its architecture is conserved among vertebrates. Synthesis of triiodothyronine (T3) and thyroxine (T4) hormones depends on the conformation, iodination and post-translational modification of TG. Although stThe thyroglobulin (TG) protein is essential to thyroid hormone synthesis, plays a vital role in the regulation of metabolism, development and growth and serves as intraglandular iodine storage. Its architecture is conserved among vertebrates. Synthesis of triiodothyronine (T3) and thyroxine (T4) hormones depends on the conformation, iodination and post-translational modification of TG. Although st

Development of the Parent-to-Infant Bonding Scale : Validation in Swedish Mothers and Fathers in Community and Clinical Contexts

Valid measurement instruments are needed to investigate the impact of parental bonding on child health development. The aim was to develop and validate a self-report questionnaire, the Parent-to-Infant Bonding Scale (PIBS) to measure bonding in both mothers and fathers. Internal consistency and construct validity were analysed using data from Swedish parents from both clinical (N = 182), and commu

A European Feminist Foreign and Security Policy? Norm Contestation and Norm Negotiations in the European Parliament

In 2020, the European Parliament (ep) issued a resolution calling for all European Union (EU) Member States to adopt feminist foreign and security policies, and for a gender-transformative vision in the EU’s own external policy. Drawing on the literatures on negotiations and norm contestation, this article3 asks why the resolution was so progressive. It also asks how we can characterize and explai