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For many years, splenectomy has been used to treat immune thrombocytopenia (ITP), and this procedure benefits approximately two-thirds of the treated patients. Although splenectomy may raise platelet counts, antibody-coated platelets and cytotoxic T lymphocytes appear to persist or can change over time. To better understand how the spleen may affect anti-platelet immune responses, we used a murine

Platelets are megakaryocyte-derived cellular fragments, which lack a nucleus and are the smallest circulating cells and are classically known to have a major role in supporting hemostasis. Apart from this well-established role, it is now becoming evident that platelets are also capable of conveying other important functions, such as during infection and inflammation. This paper will outline these

In this issue of Blood, Hou et al show the involvement of myeloid-derived suppressor cells (MDSCs) in the pathogenesis of immune thrombocytopenia (ITP) and identify a novel mechanism by which high-dose dexamethasone (HD-DXM) promotes MDSC expansion and function and correlates with increased platelet counts.

Extracellular vesicles, specifically microparticles (MPs), are rapidly gaining attention for their capacity to act as biomarkers for diagnosis, prognosis, or responsiveness to therapy in lung disease, in keeping with the concept of precision medicine. However, MP analysis by high-sensitivity flow cytometry (FCM) is complicated by a lack of accurate means for MP enumeration. To address this gap, we

Med en enkätstudie undersöks i detta projekt hur effektivt de berörda anser att de medieetiska systemen ger upprättelse. Här är det värt att nämna att vi då arbetet inleddes bad PO-kansliet om hjälp att distribuera vår enkät till alla dem som stod bakom framgångsrika anmälningar under 2015. På så sätt skulle enkäten kunna genomföras samtidigt som anonymiteten i PO-systemet kunde

Denna debattartikel argumenterar för att socialt arbete och socialtjänst behöver utvecklas i förhållande till digitalisering. Som ett led i ett samarbetsprojekt mellan Lunds universitet och Helsingborg stad, finansierat av både Vinnova och Helsingborg stad, skriver företrädare för både universitet och stad en debattartikel i DN. Hur kan socialtjänsten utvecklas med hjälp av digitalisering - nu och

Recent research on the process of biological phosphorus removal in lab-scale treatment systems has indicated that: (i) the development of an actively poly?-accumulating bacterial community after the introduction of an anaerobic period may take at least 4 months; (ii) up to 80% of all aerobic bacteria isolated from these communities are able to accumulate polyP; (iii) polyP synthesized by the bacte

Most of the genes encoding the enzymes involved in polyP synthesis and degradation and in phosphate transport have been studied in various Gram-negative bacteria. Progress has also been made in studying the biochemicalmechanisms underlying the process of enhanced biological phosphorus removal (EBPR), in particular in lab-scale systems fed with acetate or acetate plus glucose as the sole carbon and

In the light of the environmental challenges society is facing it is important thatboth products and their packaging systems are optimised from an environmental perspective. Previous research highlights that environmental optimisation of packaging requires an integrated assessment of product and packaging together.Theory on green packaging development (GPD) is comprehensive and there areexamples o

Although a diverse range of aquatic vertebrates are documented from the Upper Cretaceous (mid-Campanian) marine strata of the Kristianstad Basin in southern Sweden, only chondrichthyans and marine amniotes have been described in detail to date. In contrast, coeval actinopterygians are virtually unreported, yet their remains are extremely abundant at most sampled localities. A comprehensive assessm

During the course of this three-year project, we have studied aeolian deposits at 70 sites within sixteen areas in south-central Sweden. Inland dunes have been the focus, but some sites with coversand and coastal dunes have also been investigated. We have mapped dune morphology, mainly by LiDAR-based remote sensing, studied the internal sediment architecture by ground-penetrating radar profiling a

Mesozoic dinosaur fossils are exceptionally rare in Scandinavia. The Swedish record is typically depauperate, with the Kristianstad Basin of SkÅne (Scania) yielding all of the known fossils from Swedish Cretaceous strata. Although highly fragmentary, these body remnants are important because they provide evidence of a relatively diverse fauna, including previously recognized hesperornithiform bird

The paper gives a general discussion on methods and theories used for strength analyses of wood and wood-based products. The main aim is to discuss in general terms the benefits gained from using design approaches based on rational and scientifically sound theories. The paper presents mainly fracture mechanics theory but also other advanced modelling techniques and examples from using advanced mea

Low latency signal processing and high throughput implementations are required in order to realize real-time TDD massive MIMO communications, especially in high mobility scenarios. One of the main challenges is that the up-link and down-link turnaround time has to be within the coherence time of the wireless channel to enable efficient use of reciprocity. This paper presents a hardware architectur

In order to distinguish various film-worlds among themselves and from our intersubjective, shared reality I propose to introduce two parameters: warpedness and enfoldednes. The various ratios between these two parameters serve to create what I call »the film-world map«. The time-imageʼs embeddedness within the temporal dimension is what I mean by strong enfoldedness. A world that is enfolded is a

PurposeThe purpose of this study is to increase the understanding of multiple stakeholders’ needs, benefits and challenges, with a focus on information sharing, to improve efficiency and safety in the transportation of dangerous goods by road, rail, and sea.Design/methodology/approachInspired by grounded theory, this study is based on 21 semi-structured interviews with stakeholders representing au

Abstract Background: Surgical site infection (SSI) in the groin after vascular surgery is common and deep perivascular infection leads to long periods of hospitalization, sometimes to amputation and/or death. Negative pressure wound therapy (NPWT) is increasingly used for treating wounds such as deep perivascular groin infections after vascular surgery, but there is no scientific evidence supporti

This paper discusses the urban writing on Athenian walls as an imaginative medium of intercommunication occurring during the socioeconomic and political crisis era in Greece, over the last seven years. The street art activity on the city’s walls as a linguistic and imagery phenomenon could be approached as the main symbolic mode of public expression generated by the crisis. To investigate it field