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In this paper, we investigate the distributional properties of the estimated tangency portfolio (TP) weights assuming that the asset returns follow a matrix variate closed skew-normal distribution. We establish a stochastic representation of the linear combination of the estimated TP weights that fully characterizes its distribution. Using the stochastic representation we derive the mean and variaIn this paper, we investigate the distributional properties of the estimated tangency portfolio (TP) weights assuming that the asset returns follow a matrix variate closed skew-normal distribution. We establish a stochastic representation of the linear combination of the estimated TP weights that fully characterizes its distribution. Using the stochastic representation we derive the mean and varia

Glucose transporters (GLUTs) are responsible for transporting hexose molecules across cellular membranes. In adipocytes, insulin stimulates glucose uptake by redistributing GLUT4 to the plasma membrane. In unstimulated adipose-like mouse cell lines, GLUT4 is known to be retained intracellularly by binding to TUG protein, while upon insulin stimulation, GLUT4 dissociates from TUG. Here, we report t

Recent scandals in Iran's province of Gilan have exposed a deep-seated hypocrisy within the Islamic regime, revealing a contradiction between public moral posturing and private conduct.High-ranking officials have been caught in explicit acts, leading to public outrage. These scandals are not isolated incidents but reflect a systemic failure to uphold Islamic laws and moral codes, calling into ques

Leaked emails have revealed the Iran Experts Initiative (IEI), a covert network designed by the Islamic Republic of Iran’s diplomatic unit. Initiated in 2014, the IEI aimed to enhance Iran’s global sway by infiltrating think tanks. These leaks spotlight connections between Iranian experts and the Biden administration, extending the IEI’s influence even to European think tanks. This discovery under

Archaeological data repositories usually manage excavation data collections as project-level entities with restricted capacities to facilitate search or aggregation of excavation data at the sub-collection level (trenches, finds, season reports or excavation diaries etc.). More granular access to excavation data collections would enable layered querying across their informational content. In the p

Self-adaptation enables software to execute successfully in dynamic, unpredictable, and uncertain environments. However, most of the current approaches lack formal guarantees on the effectiveness and dependability of the adaptation mechanisms, limiting their applicability in practice. Control theory established a broad set of mathematically grounded techniques for the control of dynamic systems fo

In embedded computing domains, including the automotive industry, complex functionalities are split across multiple tasks that form task chains. These tasks are functionally dependent and communicate partial computations through shared memory slots based on the Logical Execution Time (LET) paradigm. This paper introduces a model that captures the behavior of a producer-consumer pair of tasks in a

Modern embedded software includes complex functionalities and routines, often implemented by splitting the code across different tasks. Such tasks communicate their partial computations to their successors, forming a task chain. Traditionally, this architecture relies on the assumption of hard deadlines and timely communication. However, in actual implementations, tasks may miss their deadlines, t

Security attacks on sensor data can deceive a control system and force the physical plant to reach an unwanted and potentially dangerous state. Therefore, attack detection mechanisms are employed in cyber-physical control systems to detect ongoing attacks, the most prominent one being a threshold-based anomaly detection method called CUSUM. Literature defines the maximum impact of stealth attacks

3D recording and visualization is standard practice at the Department of Archaeology and Ancient History at LU. This approach is currently used within several field projects to support documentation, data management and data analysis. The 3D data collected in the field are archived in the faculty server and are made available to researchers and students through the Lund University Digital Archaeol

Our diets greatly influence our health. Multiple lines of research highlight the beneficial properties of eating berries and fruits. In this study, a berry mixture of Nordic berries previously identified as having the potential to improve memory was supplemented to young C57Bl/6J male mice to investigate effects on cognition function, metabolic health, markers of neuroinflammation, and gut microbi

This thesis describes the use of bicyclo[3.3.1]nonane and its heteroanalogue 1,5- diazabicyclo[3.3.1]nonane as scaffolds in different supramolecular systems. The thesis is divided into two parts, with the first part (chapter 2–4) focusing on the development and applications of a synthetic receptor based on a Tröger’s base motif fused with 18-crown-6 moieties. In chapter 3, NMR titration methodolog

The production of prompt Λc+ baryons at midrapidity (|y|<0.5) was measured in central (0–10%) and mid-central (30–50%) Pb–Pb collisions at the center-of-mass energy per nucleon–nucleon pair sNN=5.02 TeV with the ALICE detector. The results are more precise, more differential in centrality, and reach much lower transverse momentum (pT=1 GeV/c) with respect to previous measurements performed by the

Hematopoietic stem cells (HSCs) are safeguarded from various threats such as stress, injury, or radiationwithin specialized microenvironments or niches within the bone marrow. In this thesis, we investigatedvarious facets of the bone marrow (BM) microenvironment and its critical role in hematopoiesis andrelated disorders.Initially, we elucidated the role of the Early Growth Response 1 (EGR1) gene

Control systems are ubiquitous and often at the core of Cyber-Physical Systems, like cars and aeroplanes. They are implemented as embedded software, that interacts in closed loop with the physical world through sensors and actuators. As a consequence, the software cannot just be tested in isolation. To close the loop in a testing environment and root causing failure generated by different parts of

Objectives: Genome-wide association studies have revealed over 200 genetic susceptibility loci for prostate cancer (PCa). By combining them, polygenic risk scores (PRS) can be generated to predict risk of PCa. We summarize the published evidence and conduct meta-analyses of PRS as a predictor of PCa risk in Caucasian men. Patients and methods: Data were extracted from 59 studies, with 16 studies i