The paravermal cerebellar cortex contains three spatially separate zones (the C1, C3 and Y zones) which form a functionally coupled system involved in the control of voluntary limb movements. A series of 'modules' has been postulated, each defined by a set of olivary neurons with similar receptive fields, the cortical microzones innervated by these neurons and the group of deep cerebellar nuclear

The ability to anticipate future events and to modify erroneous anticipatory actions is crucial for the survival of any organism. Both theoretical and empirical lines of evidence implicate the cerebellum in this ability. It is often suggested that the cerebellum acquires “expectations” or “internal models”. However, except in a metaphorical sense, the cerebellum, which consists of a set of interco

BACKGROUND: Animal studies indicate that some phthalate metabolites may harm female reproductive function. OBJECTIVES: We assessed the associations between exposure to phthalate metabolites and pregnancy loss. METHODS: Using a previously established cohort of couples planning their first pregnancy, we analyzed four primary and two oxidized secondary phthalate metabolites in urine samples collected

Carbon nanotubes (CNTs) were synthesized on liquid flame sprayed (LFS) powder substrate of iron oxide doped Al2O3-ZrO2. Iron oxide doped Al2O3-ZrO2 nanopowder was produced by injecting the liquid precursor of aluminium-isopropoxide, zirconium-n-propoxide, ferrocene and p-xylene into a high temperature (similar to 3000 K) flame. The precursor solution was atomized by high-velocity H-2 flow and inje

In AIDS vaccine development the pendulum has swung towards a renewed emphasis on the potential role for neutralizing antibodies in a successful global vaccine. It is recognized that vaccine-induced antibody performance, as assessed in the available neutralization assays, may well serve as a "gatekeeper" for HIV-1 subunit vaccine prioritization and advancement. As a result, development of a standar

Using in-depth interview material, this article explores the socially constructed and locally mediated nature of authentic leadership. The findings illustrate an irony of authentic leadership: while leaders claim that it is their true and natural selves that make them good leaders; simultaneously, they must restrain their claimed authenticity in order to be perceived as good leaders. This generate

Recension av Lars Ericson Wolke; Joseph Goebbels. En biografi.

Chronic inflammation has been strongly associated with tumor progression, but the underlying mechanisms remain elusive. Here we demonstrate that E3 ligase Itch and deubiquitinase Cyld formed a complex via interaction through 'WW-PPXY' motifs. The Itch-Cyld complex sequentially cleaved Lys63-linked ubiquitin chains and catalyzed Lys48-linked ubiquitination on the kinase Tak1 to terminate inflammato

Background: The objective of this study was to compare the efficacy of ritonavir boosted atazanavir versus ritonavir boosted lopinavir or efavirenz, all in combination with 2 nucleoside analogue reverse transcriptase inhibitors (NRTIs), over 144 weeks in antiretroviral-naive HIV-1-infected individuals. Methods: A prospective open-label randomized controlled trial was conducted at 29 sites in Swede

We present a very simple polymer model of polyethylene glycols/oxides in water that can be used in combination with Molecular Dynamics or Monte Carlo simulations to accurately reproduce the equation of state and radii of gyrations across several orders of magnitude, in terms of osmotic pressure and polymer length. This is of importance for example in osmotic stress experiments, with the aim to acc

Protein microarrays are powerful tools to quantify and characterize proteins in multiplex assays. They have great potential within clinical diagnostics and prognostics, as they minimize consumption of both analyte and biological sample. Assays that do not require labeling of the biological specimen, henceforth called label-free, are vital for ease of clinical sample processing. Here, we evaluate t

In the present study, entropy generation in rectangular cavities with the same area but different aspect ratios is numerically investigated. The vertical walls of the cavities are at different constant temperatures while the horizontal walls are adiabatic. Heat transfer between vertical walls occurs by laminar natural convection. Based on the obtained dimensionless velocity and temperature values,

Current approaches for treatment of late-stage breast cancer rarely result in a long-term cure. In part this is due to tumor stroma that prevents access of systemically or intratumorally applied therapeutics. We propose a stem cell gene therapy approach for controlled tumor stroma degradation that uses the pathophysiologic process of recruitment of inflammatory cells into the tumor. This approach

Catalytic activity of lipases (from Rhizopus arrhizus, Canadida rugosa, and Pseudomonas sp. was studied in organic media, mainly diisopropyl ether. The effect of water activity (a(w)) on V(max) showed that the enzyme activity in general increased with increasing amounts of water for the three enzymes. This was shown both for esterification and hydrolysis reactions catalyzed by R. arrhizus lipase.

Objective: to gain a deeper understanding of both parents' experiences during the mother's stay in hospital for threat of an early delivery and eventual preterm birth. Design: explanatory design with separate interviews for mothers and fathers using the grounded theory method. Setting: University Hospital in southern Sweden. Participants: 17 mothers and six fathers, who had experienced a thr