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Can we trust our memories? C. I. Lewiss coherence argument

In this paper we examine C. I. Lewis’s view on the role of coherence – what he calls “congruence” – in the justification of beliefs based on memory or testimony. Lewis has two main theses on the subject. His negative thesis states that coherence of independent items of evidence has no impact on the probability of a conclusion unless each item has some credibility of its own. The positive thesis sa

Djupanalys av tre storbränder

This report presents an analysis of three major fires in Sweden. Two of the fires concerns the industry and the third is a fire in a assembly hall. The study is based on available written material. The quality and reliability varies, and appears to depend on the aim, interest and competence of the investigator. In some cases, the information is sufficient to assess the performance of an automatic

Effects of glyceryl trinitrate, nitroprusside and nitric oxide on arterial, venous and capillary functions in cat skeletal muscle in vivo

The aim of the present study was to analyse quantitatively, on a cat gastrocnemius preparation in vivo, the effects of i.a. or i.v. administered glyceryl trinitrate (GTN), sodium nitroprusside (SNP) or nitric oxide (NO dissolved in saline) on vascular resistance (tone) in the following consecutive vascular sections: Large-bore arterial resistance vessels (> 25 microns), small arterioles (< 25 micr

Impact of DNA amplification on gene expression patterns in breast cancer

Genetic changes underlie tumor progression and may lead to cancer-specific expression of critical genes. Over 1100 publications have described the use of comparative genomic hybridization (CGH) to analyze the pattern of copy number alterations in cancer, but very few of the genes affected are known. Here, we performed high-resolution CGH analysis on cDNA microarrays in breast cancer and directly c

Disuse as cause of supersensitivity in the rat urinary bladder

Ureterostomia in situ was performed to reduce the nervous reflex activation of the bladders without concomitant hypertrophy. In muscle strips of these disused and non-hypertrophied bladders, supersensitivity to methacholine was demonstrated, which did not increase between 1 and 3 weeks. The supersensitivity did not increase further by combining urinary diversion with section of the preganglionic b

Costimulation Blockade-Induced Cardiac Allograft Tolerance: Inhibition of T Cell Expansion and Accumulation of Intragraft cD4+Foxp3+ T Cells.

Background. Previous studies have demonstrated that anti-CD40L or anti-B7 requires the presence of CD4(+)CD25(+) regulatory T cells (Treg) to induce antigen specific hyporesponsiveness. Other tolerance strategies involving Treg have shown a dependency on interleukin (IL)-10. The objective of this study was to investigate the role of CD4(+)CD25(+) Treg and IL-10 when treating transplant recipients

Evolutionary dynamics of mitochondrial plasmids in natural populations of Silene vulgaris

Although plasmid-like mitochondrial DNA molecules have been investigated in a number of cultivated plant species, knowledge about their occurrence and behavior in natural plant populations is scarce. In the bladder campion, Silene vulgaris, a common weed of northern Europe, mt-plasmids of three different sizes were detected in a survey of S. vulgaris populations in southern Sweden. Two of the thre

Bradykinin-induced airflow obstruction and airway plasma exudation: effects of drugs that inhibit acetylcholine, thromboxane A2 or leukotrienes

1 The mechanisms behind bradykinin-induced effects in the airways are considered to be largely indirect. The role of cholinergic nerves and eicosanoids, and their relationship in these mechanisms were investigated in guinea-pigs. 2 The role of cholinergic nerves was studied in animals given atropine (1 mg kg-', i.v.), hexamethonium (2 mg kg-', i.v.), or vagotomized. To study the role of eicosanoid

Implicit integration of plasticity models for granular materials

A stress integration algorithm for granular materials based on fully implicit integration with explicit updating is presented. In the implicit method the solution makes use of the gradient to the potential surface at the final stress state which is unknown. The final stress and hardening parameters are determined solving the non-linear equations iteratively so that the stress increment fulfills th

Lysozyme adsorption to charged surfaces. A Monte Carlo study

Lysozyme adsorption to charged surfaces was studied by Monte Carlo simulations at different protein concentrations, protein net charges, ionic strengths, and surface charge densities. The lysozyme was represented by a hard sphere with embedded positive and negative surface charges parametrically dependent on the solution pH. A short-range attractive protein-protein potential was included to repres

Maximum slope convolutional codes

The slope is an important distance parameter for a convolutional code. It can be used to obtain a lower bound on the active burst distance and in this respect essentially determines the error-correcting capability of the code. An upper bound on the slope of rate R = b/c convolutional codes is derived. A new family of convolutional codes, called the maximum slope (MS) code family, is introduced. Ta