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Computational modelling in systems biology: from rewriting cell fates to detecting tumours

Beräkningsmodelleringar har blivit ett allt mer viktigt verktyg inom biologisk forskning. Genom att utföra datorsimuleringar av modeller blir det möjligt att testa hur teorier om biologiska system förhåller sig till experimentell data. Simuleringar kan även användes som ersättning för potentiellt ogenomförbara experiment. En välkonstruerade modells förmåga att göra förutsägelser kan hjälpa till atComputational modelling is becoming an increasingly important tool in biological research. By performing computer simulations of models, it becomes possible to test theories about a biological system against experimental data. Simulations can also be used as a replacement for experiments otherwise unattainable. Well-constructed models have great predictive power which helps improve experimental pr

Access to psychological treatment for chronic cancer-related Pain in Sweden

ObjectivesCancer related pain (CRP) is among the most frequent collateral effects of cancer, with chronic CRP, lasting at least three months, affecting >40% of cancer survivors.Evidence based treatments, including pain-focused Cognitive Behavioral Therapy(CBT) are available, but it appears that cancer patients/survivors are often poorlyinformed about CRP or the potential benefits of CBT for such p

Sikh News in India, 1864–1924: Colonial Reports on Vernacular Newspapers of Punjab : Volume One: Royalties, Reformers, and Organizations

After the Indian Rebellion of 1857, the colonial administration in British India introduced stricter control over Indian publishers and the press printed in various indigenous languages. Newspapers in the Punjab were monitored and scrutinized from 1864 to understand “native opinions” and identify seditious tendencies. The surveillance resulted in extensive weekly press reports that were considered

Occurrence of impaired fasting glucose in GH‐deficient adults receiving GH replacement compared with untreated subjects

Objective: The effects of GH replacement on glucose metabolism in GH-deficient (GHD) adults in clinical practice are not well defined. Therefore, we assessed GH treatment effects on fasting plasma glucose (FPG) and haemoglobin A1c (A1c) concentrations in GHD adults in a clinical setting.Design: Post-hoc analysis of the observational Hypopituitary Control and Complications Study conducted at 157 US

Visualizing the Mechanism Switching in High-Temperature Au-Catalyzed InAs Nanowire Growth

We use environmental transmission electron microscopy to observe in situ the switch from an axial vapor-liquid-solid (VLS) growth mechanism in Au-catalyzed InAs nanowires toward a radial vapor-solid (VS) one, dominated by layers nucleating at the triple-phase line. At elevated temperatures, in addition to high V/III ratios, the affinity for In in the Au catalyst will be greater than that of In in

Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study

Aims Although highly heritable, the genetic etiology of calcific aortic stenosis (AS) remains incompletely understood. The aim of this study was to discover novel genetic contributors to AS and to integrate functional, expression, and cross-phenotype data to identify mechanisms of AS. Methods and results A genome-wide meta-analysis of 11.6 million variants in 10 cohorts involving 653 867 European

Farmland practices are driving bird population decline across Europe

Declines in European bird populations are reported for decades but the direct effect of major anthropogenic pressures on such declines remains unquantified. Causal relationships between pressures and bird population responses are difficult to identify as pressures interact at different spatial scales and responses vary among species. Here, we uncover direct relationships between population time-se

Collegial midwifery assistance during the active second stage of labour

AbstractSevere perineal trauma (SPT) is a serious complication following vaginal birth. To reduce its incidence rate, various preventive strategies have been implemented in Swedish obstetric units. Collegial midwifery assistance (CMA), involving an additional midwife being present during the active second stage of labour, is a clinical practice that was evaluated in the Oneplus trial, which proved

Ecological barriers mediate spatiotemporal shifts of bird communities at a continental scale

Species’ range shifts and local extinctions caused by climate change lead to community composition changes. At large spatial scales, ecological barriers, such as biome boundaries, coastlines, and elevation, can influence a community's ability to shift in response to climate change. Yet, ecological barriers are rarely considered in climate change studies, potentially hindering predictions of biodiv