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Monogenic Parkinson's disease and parkinsonism: Clinical phenotypes and frequencies of known mutations.

Mutations in seven genes are robustly associated with autosomal dominant (SNCA, LRRK2, EIF4G1, VPS35) or recessive (parkin/PARK2, PINK1, DJ1/PARK7) Parkinson's disease (PD) or parkinsonism. Changes in a long list of additional genes have been suggested as causes for parkinsonism or PD, including genes for hereditary ataxias (ATXN2, ATXN3, FMR1), frontotemporal dementia (C9ORF72, GRN, MAPT, TARDBP)

Force Controlled Robotic Assembly without a Force Sensor

The traditional way of controlling an industrial robot is to program it to follow desired trajectories. This approach is sufficient as long as the accuracy of the robot and the calibration of the workcell is good enough. In robotic assembly these conditions are usually not fulfilled, because of uncertainties, e.g., variability in involved parts and objects not gripped accurately. Using force contr

Abnormal cerebellar development and ataxia in CARP VIII morphant zebrafish

Congenital ataxia and mental retardation are mainly caused by variations in the genes that affect brain development. Recent reports have shown that mutations in the CA8 gene are associated with mental retardation and ataxia in humans and ataxia in mice. The gene product, carbonic anhydrase-related protein VIII (CARP VIII), is predominantly present in cerebellar Purkinje cells, where it interacts w

Structure from Motion Estimation with Positional Cues

We present a system for structure from motion estimation using additional positioning data such as GPS data. The system incorporates the additional data in the outlier detection, the initial estimates and the final bundle adjustment. The initial solution is based on a novel objective function which is solved using convex optimization. This objective function is also used for outlier detection and

On the probability of non-shared multipath clusters in cellular networks

In Space Division Multiple Access (SDMA) systems, users are separated based on their positions. The base-station (BS) signals typically reach the users through multipath clusters. The goal of this work is to find the probability that a randomly selected user will receive the signal from the BS via at least one nonshared (by any other user) multipath cluster. This probability, referred to as PSucce

Rao-Blackwellisation of particle Markov chain Monte Carlo methods using forward filtering backward sampling

Abstract in UndeterminedSmoothing in state-space models amounts to computing the conditional distribution of the latent state trajectory, given observations, or expectations of functionals of the state trajectory with respect to this distribution. In recent years there has been an increased interest in Monte Carlo-based methods, often involving particle filters, for approximate smoothing in nonlin

Clinical review: Continuous and simplified electroencephalography to monitor brain recovery after cardiac arrest.

There has been a dramatic change in hospital care of cardiac arrest survivors in recent years, including the use of target temperature management (hypothermia). Clinical signs of recovery or deterioration, which previously could be observed, are now concealed by sedation, analgesia, and muscle paralysis. Seizures are common after cardiac arrest, but few centers can offer high-quality electroenceph

Monitoring rFVIIa 90 μg kg(-1) dosing in haemophiliacs: comparing laboratory response using various whole blood assays over 6 h.

Summary. Recombinant FVIIa is a haemostatic agent administered to patients with severe FVIII or FIX deficiency with inhibitors. Although rFVIIa is effective at stopping bleeding, a reliable assay to monitor its effect is lacking. To characterize the pharmacokinetics and global coagulation effects of rFVIIa for 6 h following a IV dose of 90 μg kg(-1) . Ten non-bleeding subjects with severe FVIII or

The Effects of Climate Change on Cardiac Health

The earth's climate is changing and increasing ambient heat levels are emerging in large areas of the world. An important cause of this change is the anthropogenic emission of greenhouse gases. Climate changes have a variety of negative effects on health, including cardiac health. People with preexisting medical conditions such as cardiovascular disease (including heart failure), people carrying o

Smart, smarter, smartest: foraging information states and coexistence

Animals possess different abilities to gain and use information about the foraging patches they exploit. When ignorant of the qualities of encountered patches, a smart forager Should leave all patches after the same amount of fixed search time. A smarter forager can be Bayesian by using information Oil Cumulative harvest and time spent searching a patch to better inform its patch-departure decisio

Multiexciton Absorption Cross Sections of CdSe Nanocrystals at Band-Edge Energy

Picosecond transient absorption signals of two kinds of cadmium selenide quantum dots were measured at various excitation intensities. The average number of excitons per quantum dot was calculated from a Poisson model, which together with kinetic parameters was used to determine exciton population kinetics. Exciton and multiexciton absorption cross sections were determined and analyzed in terms of

Human induced pluripotent stem cell-derived cortical neurons integrate in stroke-injured cortex and improve functional recovery.

Stem cell-based approaches to restore function after stroke through replacement of dead neurons require the generation of specific neuronal subtypes. Loss of neurons in the cerebral cortex is a major cause of stroke-induced neurological deficits in adult humans. Reprogramming of adult human somatic cells to induced pluripotent stem cells is a novel approach to produce patient-specific cells for au

Femtoscopy of pp collisions at root s=0.9 and 7 TeV at the LHC with two-pion Bose-Einstein correlations

We report on the high statistics two-pion correlation functions from pp collisions at root s = 0.9 TeV and root s = 7 TeV, measured by the ALICE experiment at the Large Hadron Collider. The correlation functions as well as the extracted source radii scale with event multiplicity and pair momentum. When analyzed in the same multiplicity and pair transverse momentum range, the correlation is similar

Epithermal Gold Mineralization in the Trenggalek District, East Java, Indonesia

Gold-mineralized quartz veins at the Trenggalek district of the Southern Mountains Range in East Java, Indonesia, are hosted by Oligo-Miocene volcaniclastic and volcanic rocks, and are distributed close to andesitic plugs in the northern prospects (Dalangturu, Suruh, Jati, Gregah, Jombok, Salak, and Kojan) and the southern prospects (Sentul and Buluroto). The plugs are subalkaline tholeiitic basal