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Developing rights-based standards for children having tests, treatments, examinations and interventions : using a collaborative, multi-phased, multi-method and multi-stakeholder approach to build consensus
Children continue to experience harm when undergoing clinical procedures despite increased evidence of the need to improve the provision of child-centred care. The international ISupport collaboration aimed to develop standards to outline and explain good procedural practice and the rights of children within the context of a clinical procedure. The rights-based standards for children undergoing te
Brain Fingerprinting Using FMRI Spectral Signatures On High-Resolution Cortical Graphs
Resting-state fMRI has proven to entail subject-specific signatures that can serve as a fingerprint to identify individuals. Conventional methods are based on building a connectivity matrix based on correlation between the average time course of pairs of brain regions. This approach, first, disregards the exquisite spatial detail manifested by fMRI due to working on average regional activities, se
Experimental study on a -86 °C cascade refrigeration unit with environmental-friendly refrigerants R290-R170
Ultralow-temperature refrigeration faces significant issues linked to the security of the cold chain for the production, storage, transportation, and distribution of COVID-19 vaccines. The use of environmentally friendly refrigerants in cascade refrigeration systems (CRS) to provide low-temperature range is motivated by the high demand for ultralow-temperature refrigeration units. In the current s
A Modular System-level Testbench for 6G Beamforming Applications with Near Circuit-Level Fidelity
Sub-THz frequencies are tomorrow's hot research area in mobile communication. However, in this range of frequencies the systems are complex, and it is hard to explore various system architectures and correlate the system-level solutions with circuit-level performances and requirements. This paper presents a scalable testbench in MATLAB/Simulink for sub-THz hybrid beamforming receivers. The testben
A comparison of men and women undergoing septoplasty—the Swedish national septoplasty register
Objective: Men represent more than two-thirds of septoplasty patients in many studies, but differences between men and women in terms of patient selection or outcome are seldom reported. This study aims to investigate whether women undergoing septoplasty differ from men in critical variables before and after surgery, in a large national sample of septoplasties. Design: Cross-sectional register stu
First-Line Venetoclax Combinations in Chronic Lymphocytic Leukemia.
Background Randomized trials of venetoclax plus anti-CD20 antibodies as first-line treatment in fit patients (i.e., those with a low burden of coexisting conditions) with advanced chronic lymphocytic leukemia (CLL) have been lacking. Methods In a phase 3, open-label trial, we randomly assigned, in a 1:1:1:1 ratio, fit patients with CLL who did not have TP53 aberrations to receive six cycles of che
Lysozyme-Sucrose Interactions in the Solid State : Glass Transition, Denaturation, and the Effect of Residual Water
The freeze-drying of proteins, along with excipients, offers a solution for increasing the shelf-life of protein pharmaceuticals. Using differential scanning calorimetry, thermogravimetric analysis, sorption calorimetry, and synchrotron small-angle X-ray scattering (SAXS), we have characterized the properties at low (re)hydration levels of the protein lysozyme, which was freeze-dried together with
Diversity Audit of Medical School Examination Questions
Phenomenon: This article reports the under-researched presentation of demographic, social, and economic diversity in medical school examination questions. Approach: The present study audited 3,566 pre-clinical and clinical multiple-choice and short answer examination questions in the same year (2018) from three medical schools in two continents to review the diversity of patients portrayed. The au
Development and Evaluation of eHealth Services Regarding Accessibility : Scoping Literature Review
Background: Accessibility is acknowledged as a key to inclusion in the Convention of Rights for People with Disabilities. An inaccessible design can result in exclusion from eHealth and cause disability among people who have impairments. Objective: This scoping literature review aimed to investigate how eHealth services have been developed and evaluated regarding accessibility for people with impa
Antimicrobial peptide therapy for tuberculosis infections
Tuberculosis is a communicable disease that persists as a second leading cause for death, by an infectious agent. Several reasons contribute to this issue to this, of which an upsurge in antibiotic resistance is of top concern. Resistance patterns in the form of mono or multidrug resistance was reported to most clinical therapies at our disposal. This thesis aims to address this issue by studying
LINE-1 retrotransposons drive human neuronal transcriptome complexity and functional diversification
The genetic mechanisms underlying the expansion in size and complexity of the human brain remain poorly understood. Long interspersed nuclear element-1 (L1) retrotransposons are a source of divergent genetic information in hominoid genomes, but their importance in physiological functions and their contribution to human brain evolution are largely unknown. Using multiomics profiling, we here demons
Are brief admissions helpful for adolescents with borderline personality traits? - Authors' reply
Molecular Recognition Materials Synthesized Based on Small molecules, DNA, and Imprinted Polymers for Bioanalytical Applications
The development of sensitive, convenient, and cost-effective methods for detecting disease biomarkers is very important for meeting the growing demand for early clinical diagnosis. Additionally, the detection of disease biomarkers at ultralow concentrations is very important for disease prevention and treatment and posttreatment rehabilitation. However, current ultrasensitive detection strategies
Creating age-friendly environments in a smart society in China: a policy review
Technology is increasingly being integrated into Age-Friendly Environments (AFEs). This study explores how technology is manifested in AFE policies in China. We conducted a content analysis of 176 policies spanning seven years to identify the relationship between technology and AFEs, and the characteristics of policy development. The findings indicate that technology plays a role in advancing a sm
“My goal is to have zero” : Parenting, screen time and moral imaginaries
Temporal visualizations : Screen time and visual morality
Generalized anxiety disorder (GAD) in children and adolescents
Children with generalized anxiety disorder (GAD) are often described by their parents or teachers as "little adults, " in part because of the seemingly adult-like themes that populate their child's worries; for example, the health of family members or family finances and concerns about performance. Younger children may experience more vague worries of "something" bad happening to themselves, famil
Multi-scale wave modelling; Field validation in Faxe Bay, Denmark
Access to local nearshore wave climate conditions on a detailed spatial scale is important for many coastal engineering practices. These include assessing the flood risk of coastal infrastructure, designing coastal protection measures, and estimating sediment transport processes and wave run-up. The present study displays a multi-scale wave modelling approach using the numerical wave model SWAN (B
Actors, knowledge and soft skills for implementing the reuse of building materials
Globally, there is a widespread consensus that the transition to circular economy (CE) within the construction industry represents a crucial pathway to achieve the decarbonization of the industry by 2050 while fostering economic growth. At the European level, policies and legislations are progressively promoting the use of circular building products and encouraging higher levels of energy and reso