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Microglial cells are affected in Alzheimer's disease (AD) and interact with amyloid-beta (Aβ) plaques. Apart from memory loss, depression is common in patients with AD. Electroconvulsive therapy (ECT) is an anti-depressive treatment that may stimulate microglia, induce neuroinflammation and alter the levels of soluble Aβ, but the effects of ECT on microglia and Aβ aggregation in AD are not known.

We investigate how users on a prominent forum for white supremacists interpreted and framed two seminal events for the far-right in the U.S., the elections of Obama in 2008 and Trump in 2016. These cases precipitated dramatic shifts in the far-right alliance and conflict structure. We combine computational methods and qualitative analysis on a corpus of over ten million posts on Stormfront.org to We investigate how users on a prominent forum for white supremacists interpreted and framed two seminal events for the far-right in the U.S., the elections of Obama in 2008 and Trump in 2016. These cases precipitated dramatic shifts in the far-right alliance and conflict structure. We combine computational methods and qualitative analysis on a corpus of over ten million posts on Stormfront.org to

The determination of toxic components from fire gases is difficult because the environment is hot, reactions are often temperature dependent, and a lot of soot may be produced. Due to the different properties of the gas components, a different time-consuming procedure for each species has traditionally been used. The use of FTIR (Fourier transform infrared) spectrometers as a continuous monitoring

The composition of enclosure materials used in many TV sets sold on the European market has changed significantly since the early 1990s. To determine the potential impact of this change on TV fire safety, a review of European and US TV set fire statistics has been carried out. TV set fires can have internal electrical causes due to faults not apparent at the time of manufacture, simple wear and te

The amount of various pollutants per year emitted into the atmosphere from fires in Sweden is estimated. The pollutants considered in detail are CO2, CO, HCN, NOx, SO2, HCl, unburned hydrocarbons, and particulate matter. The emission of N2O, aromatic hydrocarbons, dioxins, and heavy metals, is discussed qualitatively. The estimate is based on the number of fires in buildings and vehicles in Sweden

A new many-body expansion (MBE) fit of the A″ surface associated with the reaction of atomic carbon and NO is presented. Trajectory calculations, based on this surface, of the rate coefficients for the reactions C(3P) + NO(X2Π) k1 CN(X2∑+) + O(3P) and C(P) + NO(X2Π k2 CO(X1∑+) + N(2D) are compared to experimental results over a range of temperatures from room temperature to combustion temperatures

We use RRKM theory to calculate rate constants and product branching fractions for NH+NO, comparing results for an ab initio surface and two recent empirical surfaces. In addition we compare trajectory and RRKM branching fractions based on the empirical surfaces, including an assessment of zero-point energy effects on branching. Our calculations show that the ab initio and empirical surfaces give

The two lowest potential energy surfaces for C(3P)+NO(2Π) have been investigated. The stationary points were first located using CASSCF gradient calculations and the geometries reoptimized using complete active space second-order perturbation theory. Zero-point corrections have been included in the energetics. In addition to the three linear conformations CNO, NCO and CON, a previously unreported

Self-consistent field ab initio calculations using a previously published, optimized basis set [J. Chem. Phys. 94 (1991) 6677] and second-order Møller-Plesset (MP2) perturbation theory are used in a study of the ArHCl intermolecular potential. The ab initio results are compared to the recently published H6(4, 3, 0) potential-energy surface [J. Phys. Chem. 96 (1992) 4237]. Good agreement is obtaine

Combustion of methane with air in the presence of hydrogen chloride was studied in a turbulent jet-stirred burner. The reaction was monitored by in situ mass spectometry and the ratio of Cl2 2HCl intensities was measured as a function of equivalence ratio (Φ). For values of Φ = 1.25 - 0.5 (fuel rich to fuel lean flames) the ratio of Cl2 2HCl intensities was close to zero. For values of Φ < 0.5 the

An integrated flat-flame/ microprobe sampling quadrupole mass spectrometer system, complemented by optical spectrometry based on optical fibers, is presented. The short microprobe sampling line (total 25 cm) is directly connected to an open ion source closely flanked by two nude cryopumps (900 l/s) yielding a background pressure of 10-9 Torr and a sampling pressure of about 10-5 Torr. Due to this

For the past 30 to 40 years, regulation of the environment has been governed by Environmental Protection Agencies worldwide. During this time we have learned that regulations have significant costs, not just benefits, and that analysis of the cost and benefit of proposed rules is an indispensable component of responsible regulation. Despite present-day recognition of the importance of cost benefit

This study has examined the distribution patterns between gas phase and particle phase of some chemical compounds produced in fires. It has also addressed the question of the distribution of individual particle-associated species between the different size-ranges of particles. The chemical compounds studied and discussed in this paper are polycyclic aromatic hydrocarbons (PAHs), and isocyanates. T

Fires in convalescent homes and elderly care facilities represent a statistically significant threat to their residents, who tend to be less mobile and therefore less able to escape harm. This threat is expected to increase as demographics shift and more people move into this type of facility. A study has been conducted in Sweden to investigate the means by which fire protection and response can b

A number of large-scale fire experiments with detailed quantitative analysis of polycyclic aromatic hydrocarbon (PAH) including PAH congener distribution have been conducted by SP. This data is reviewed here and is further assessed with regard to toxicity applying a Toxic Equivalency Factor (TEF) model for estimation of cancer potential. The PAH yield data from the large-scale fire experiments is

SP Fire Technology is planning the ETANKFIRE research project on ethanol tank firefighting jointly with the Swedish Petroleum Institute. The aim of the ETANKFIRE project is to develop and validate a methodology for fire protection and suppression of ethanol storage tank fires, and to determine the burning behavior of ethanol fuels. Experience from small-scale fires shows that radiation is lower fr

The impact of fires on humans and the environment has been the subject of investigation for decades. We have a variety of more or less well developed models to study the impact of fires on humans and even have several international standards categorising standardised approaches to quantifying the toxic potency of fire gas exposure. However, there is currently no standardised approach available to

The characterisation of fire effluents from large-scale fire tests is important for assessing the risks associated with specific scenarios regarding buildings and transport, and also for validation of effluent data from small-scale tests. This chapter describes some of the most important standard large-scale test scenarios and modifications of these tests including gas analysis. It will further de

Fire-LCA was invented in response to the need for a more holistic LCA of products containing flame retardants. This chapter describes how to conduct a Fire-LCA, illustrated using three product-based case studies: TV sets, furniture and cables. In the TV-set study a US TV was compared with a European TV, the furniture study compared a European sofa with a UK sofa, while two cables with similar fire