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Background: The transient receptor potential ankyrin 1 (TRPA1) channel, localized to airway sensory nerves, has been proposed to mediate airway inflammation evoked by allergen and cigarette smoke (CS) in rodents, via a neurogenic mechanism. However the limited clinical evidence for the role of neurogenic inflammation in asthma or chronic obstructive pulmonary disease raises an alternative possibil

Background Atopic dermatitis (AD) is caused by a complex interplay between immune and barrier abnormalities. Murine models of AD are essential for preclinical assessments of new treatments. Although many models have been used to simulate AD, their transcriptomic profiles are not fully understood, and a comparison of these models with the human AD transcriptomic fingerprint is lacking. Objective We

From its inception, leadership studies has embraced the positivist tradition of hypothesis testing. In this tradition, psychometric instruments are meant to ward off belief from scientific practice by testing theories against empirical facts. While leadership scholars purport to conform to the standards of value-neutral science, this paper tells a different story. Drawing on qualitative interviews

The boreal biome exchanges large amounts of carbon (C) and greenhouse gases (GHGs) with the atmosphere and thus significantly affects the global climate. A managed boreal landscape consists of various sinks and sources of carbon dioxide (CO2), methane (CH4), and dissolved organic and inorganic carbon (DOC and DIC) across forests, mires, lakes, and streams. Due to the spatial heterogeneity, large u

Event-based sampling has been proposed as a general technique for lowering the average communication rate, energy consumption and computational burden in remote state estimation. However, the design of the event trigger is critical for good performance. In this paper, we study the combination of innovation-based triggering and state estimation of nonlinear dynamical systems using the particle filt

Oxidative stress is one of the earliest events in the pathogenesis of Alzheimer's disease (AD) and can markedly exacerbate amyloid pathology. Modulation of antioxidant and anti-inflammatory pathways represents an important approach for AD therapy. Synthetic triterpenoids have been found to facilitate antioxidant response and reduce inflammation in several models. We investigated the effect of the

Introduction: Dystonia-deafness syndrome is a distinct clinical presentation within the dystonia-spectrum. Although several genetic and acquired causes have been reported, etiology remains unknown in the majority of patients. Objectives: To describe two patients with dystonia-deafness syndrome due to a beta-actin gene mutation. Methods: We report on disease course, genetic testing, and management

This thesis work concerns the further developments of dual-broadband rotational coherent anti-Stokes Raman spectroscopy (RCARS) through experimental and theoretical investigations. Rotational CARS is an established technique for gas-phase thermometry and concentration measurement with major applications in combustion diagnostics. The technique has previously mainly been applied on species with lin

This dissertation deals with finite-size effects in a few different quantum many-body phenomena in ultracold atomic systems. The finite-sized systems were simulated numerically using both mean-field methods and methods beyond mean-field, e.g. quadratic configuration interaction and exact diagonalization. The thesis is based on five scientific papers:Paper I is about the finite-size effects in the

Iron can be a growth‐limiting nutrient for phytoplankton, modifying rates of net primary production, nitrogen fixation, and carbon export ‐ highlighting the importance of new iron inputs from the atmosphere. The bioavailable iron fraction depends on the emission source and the dissolution during transport. The impacts of anthropogenic combustion and land use change on emissions from industrial, do

Early aetiological diagnosis is of paramount importance for childhood dystonia because some of the possible underlying conditions are treatable. Numerous genetic and non-genetic causes have been reported, and diagnostic workup is often challenging, time consuming and costly. Recently, a paradigm shift has occurred in molecular genetic diagnostics, with next-generation sequencing techniques now all

Försäkringskassan är den myndighet som administrerar huvuddelen den svenska socialförsäkringen. Medborgarnas förtroende för myndigheten har i olika mätningar visat sig vara lågt. Syftet med den här studien är att fördjupa förståelsen och kunskapen om Försäkringskassan förtroendesiffror genom att undersöka hur smärtdrabbade individer upplever mötet med myndigheten. Smärtdrabbade individer har som g

Sweden was unique in early modern Europe, in that its parliament included a peasant farmer estate. It is commonplace in Swedish and international research to consider the peasant farmer politicians as guarantors of a liberal and egalitarian path of development. In the Swedish-language literature on political history, these people are often seen as rather narrow-minded, their common political progr

We investigate the possibility of finding Earth-like planets in the habitable zone of 34 nearby FGK-dwarfs, each known to host one giant planet exterior to their habitable zone detected by RV. First we simulate the dynamics of the planetary systems in their present day configurations and determine the fraction of stable planetary orbits within their habitable zones. Then, we postulate that the ecc

The recent surge of scientific interest for lead halide perovskite semiconductors and optoelectronic devices has seen a mix of materials science sub-fields converge on the same "magical" crystal structure. However, this has ultimately shaped some ambiguity in the definitions shared between researchers across different research areas. For example, scientists aiming to decipher the nature of localiz