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This study evalluated the role of endogenous Annexin A1 in the regulation of theNLRP3 inflammasome. B57bl/6 wild-type (WT) and knockouts for ANXA1 (ANXA1-/-) received intraperitoneal injection of 1.5% starch solution for macrophagesrecruitment. NLRP3 was activated by priming cells with lipopolysaccharide (500ng/mL) for 3 hours, followed by nigericin (10 µM for 1 hour) or ATP (5 mM for 30minutes).
There is perennial debate in comparative politics about electoral institutions, but what characterizes this debate is the lack of consideration for citizens’ perspective. In this paper, we report the results of an original survey conducted on representative samples in 15 West European countries (N = 15,414). We implemented an original instrument to elicit respondents’ views by asking them to rate
Background: Gastrointestinal (GI) symptoms similar to irritable bowel syndrome (IBS) are often present in women with endometriosis and microscopic colitis (MC). The objective of this study was to estimate GI symptoms in IBS, endometriosis, and MC, to compare the clinical expression of the diseases. Methods: Women with IBS, endometriosis, and MC were identified by diagnosis codes at a tertiary cent
Eye tracking (ET) has been used extensively in driver attention research. Amongst other findings, ET data have increased our knowledge about what drivers look at in different traffic environments and how they distribute their glances when interacting with non-driving related tasks. Eye tracking is also the go-to method when determining driver distraction via glance target classification. At the sa
In this paper, we investigate the security of SNOW-V, demonstrating two guess-and-determine (GnD) attacks against the full version with complexities 2384 and 2378, respectively, and one distinguishing attack against a reduced variant with complexity 2303 . Our GnD attacks use enumeration with recursion to explore valid guessing paths, and try to truncate as many invalid guessing paths as possible
Compensational voting refers to when voters cast a vote for a more extreme party than they prefer, in order to push policies closer to an ideal point. This article develops the idea of compensational voting in regard to pre-electoral coalition signals and polling trends. The argument is that a significant share of voters consider the relative strength of the parties in their preferred pre-electoraCompensational voting refers to when voters cast a vote for a more extreme party than they prefer, in order to push policies closer to an ideal point. This article develops the idea of compensational voting in regard to pre-electoral coalition signals and polling trends. The argument is that a significant share of voters consider the relative strength of the parties in their preferred pre-electora
Dysfunctional water, sanitation and hygiene (WaSH) systems are mainly determined by poor water governance, exacerbating inequalities and poverty. Multi-stakeholder partnerships provide an approach to more flexible and adaptive governance to explore these problems. In this article, national commitments made to improve WaSH, made through the Sanitation and Water for All (SWA) partnership’s Mutual Ac
SNOW 3G is a stream cipher used as one of the standard algorithms for data confidentiality and integrity protection over the air interface in the 3G and 4G mobile communication systems. SNOW-V is a recent new version that was proposed as a candidate for inclusion in the 5G standard. In this paper, we propose a faster variant of SNOW-V, called SNOW-Vi, that can reach the targeted speeds for 5G in a
Moody et al. (2018) presented a unified model of information security policy compliance (UMISPC) to explain information systems security (ISS) behaviors. The model was empirically tested against 3 main types of security-related behavior: USB practices, not locking computers appropriately, and password issues. In this study, we present a conceptual replication of Moody et al. (2018) in order to pro
Resource recovery and reuse (RRR) of fecal sludge (FS) from onsite sanitation systems describes the concept of turning human waste into valuable end products. However, studies on peoples’ perceptions of FS-derived products are still limited. Guided by the knowledge, attitudes and practices framework, and data from a survey of 395 households, focus group discussions and key informant interviews, th
Traditional network architecture design of Low Power Wide Area Networks (LPWAN) is incapable of dynamically scaling resources based on the served traffic and requires manual procedures for network capacity upgrades. Today's over-provisioning approach based on proprietary hardware (HW) would not be cost and energy efficient to cope with the ever-increasing scale of Internet of Things (IoT) devices
Groups associated to surfaces isogenous to a higher product of curves can be characterized by a purely group-theoretic condition, which is the existence of the so-called ramification structure. In this paper, we prove that infinitely many quotients of the Grigorchuk groups admit ramification structures. This gives the first explicit infinite family of 3-generated finite 2-groups with ramification
Larry Temkin has forcefully argued for the possibility that the value comparative “better than” is not transitive and that the betterness relation can be cyclical. Temkin uses so-called spectrum arguments to argue that the belief that “better than” is transitive is incompatible with other beliefs that are more intuitive, so we should conclude that “better than” is not transitive. I will argue that
In this contribution, a model for the thermomechanically coupled behaviour of case hardening steel is introduced with application to 16MnCr5 (1.7131). The model is based on a decomposition of the free energy into a thermo-elastic and a plastic part. Associated viscoplasticity, in terms of a temperature-depenent Perzyna-type power law, in combination with an isotropic von Mises yield function takes
Values, such as liberty and equality, are sometimes said to be incommensurable in the sense that their value cannot be reduced to a common measure. And options, such as studying to become a lawyer or studying to become a philosopher, are sometimes said to be incomparable in the sense that neither option seems to be at least as good as the other. These possibilities are thought to raise deep questi
