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Src homology 2 (SH2) domains recognize phosphotyrosine (pY)-containing sequences and thereby mediate their association to ligands. Bruton's tyrosine kinase (Btk) is a cytoplasmic protein tyrosine kinase, in which mutations cause a hereditary immunodeficiency disease, X-linked agammaglobulinemia (XLA). Mutations have been found in all Btk domains, including SH2, We have analyzed the structural and

Recension av Sofie Lene Bak, Jødeaktionen oktober 1943. Forestillinger i offentlighed og forskning

This thesis explores the ritual dimensions of the mortuary practices in the late Mesolithic cemeteries at Skateholm in Southern Sweden and Vedbæk-Bøgebakken in Eastern Denmark. With a combination of methods and theories that all focus on the ritual practices as action, a new approach to burials in archaeology is proposed. Special attention is given to the treatment of the body after death, which i

This thesis is a critique of the New Institutional Economics (NIE) in economic history. The focus is on explanations to the origin and development of capitalist institutions within NIE. After a methodological discussion in chapter 1 the author investigates into how well NIE succeeds in explaining capitalist institutions. In chapters 2 and 3, a conceptual critique of the theoretical bases of evolu

Objective: To examine and compare the adult outcome in a representative sample of hospitalized adolescent-onset psychoses including occupational and social aspects. Method: A total of 81 patients with a first episode of early-onset psychosis (before age 19 years) presenting to the University Hospital of Lund, Sweden, between 1982 and 1993 were followed up an average of 10.5 years (range 5.1-18.2)

Popular Abstract in Swedish Teknikutvecklingen leder till att vi får allt mer avancerade elektroniska medicinska implantat. Dessa spänner idag från den välkända hjärtpacemakern till avancerade hörselimplantat, hjärnstimulatorer och implanterbara medicinpumpar. Med de allt mer avancerade implantaten har också deras behov av att ta emot styrsignaler från utsidan av kroppen, och deras förmåga att sänWith the increased sophistication of medical implants, there is a growing need for flexible high-speed communication with the implant from outside the body. Today the communication is done by an inductive link between the implant and an external coil at a low carrier frequency. Extended range and communication speed are possible to achieve by increasing the carrier frequency and the bandwidth. One

Artikeln behandlar de svårigheter som uppstår i den offentliga debatten av konstutställningar när ämnet för utställningen är sexualiteter utanför den heterosexuella normaliteten. De bägge utställningar som behandlas, Donald Maders medverkan i Bjarne Mellgaards "Softcore" och Elisabeth Olsson-Wallins "Ecce Homo", väckte båda mycket starka reaktioner. Essän reder ut hur denna storm tar sin form i de

Popular Abstract in Swedish Döva barns begreppsbildning i matematik Denna studie tar utgångspunkt i frågan varför många döva barn har svårt att lära sig matematik. Studiens syfte är att belysa döva barns begreppsbildning i ämnet matematik genom att beskriva hur några döva barn uttrycker sig och agerar på väg mot förståelse av två centrala matematiska begrepp, nämligen multiplikation med heltal ochThe question why deaf children have difficulties in learning mathematics is the basis of this study. The aim of the study is to illuminate deaf children’s concept formation in mathematics by describing how some deaf children express themselves and act on their way towards understanding two basic concepts, the concept of multiplication with whole numbers and the concept of length. Theories develope

In the framework of the ESO Large Programme ``First Stars'', veryhigh-quality spectra of some 70 very metal-poor dwarfs and giants wereobtained with the ESO VLT and UVES spectrograph. These stars are likelyto have descended from the first generation(s) of stars formed after theBig Bang, and their detailed composition provides constraints on issuessuch as the nature of the first supernovae, the eff

The use of monoclonal antibodies (MAbs) in cytotoxic conjugates (radionuclides, toxins, or drugs) for targeting tumor cells is restricted due to toxicity in vital organs. Through improved tumor targeting, it is possible to administer larger amounts of such labeled MAbs, thus improving the ability to eradicate tumor cells without increased normal organ toxicity. Extracorporeal affinity adsorption t

Background: Foods with a low glycemic index are increasingly being acknowledged as beneficial for individuals with disorders related to the insulin resistance syndrome. The presence of certain salts of organic acids has been shown to lower the glycemic index of bread products and one of the suggested mechanisms is a lowered gastric emptying rate (GER). One obvious pitfall with many of the common t

Popular Abstract in Swedish Avhandlingen består av två delar. I den första delen används rent potentialteoretiska metoder för att studera hinderproblemet hörande till en likformigt elliptisk andra ordningens differentialoperator på divergensform. Reguljära punkter till hindren karakteriseras med det klassiska Wiener-kriteriet. Andra delen behandlar en klass av funktioner som uppfyller en viss intThe thesis consists of two parts. In the first part pure potential theoretic methods are employed to study the obstacle problem connected with a uniformly elliptic second-order differential operator in divergence form. Regular points of the obstacles are characterized by the classical Wiener criterion. The second part deals with a class of functions satisfying a certain integral inequality. A pr

BACKGROUND: The clinically important Kidd (JK) blood group antigens are carried by the urea transporter in red cells. The rare Jk(a-b-) phenotype can be caused by homozygosity at the JK locus for a silent allele, JK: This phenotype has been recorded in many ethnic groups, but it is most abundant among people originating from the Polynesian Islands and Finland. The molecular basis for Jk(a-b-) is u

The ability to perceive and express emotional, as well as number of linguistic prosodic qualities of speech was tested in 20 Swedish-speaking patients with right-sided cortical, as well as purely subcortical brain infarcts, and in 18 normal controls. The infarcts were assessed by clinical neurological examination, and by CT, EEG, and measurements of regional cerebral blood flow (rCBF). In the pati

Extraction constants for the solvent extraction of hydrofluosilicic acid with Alamine 336 have been determined. Two species were identified, (R3NH+ )2 SiF62- and R3NH+ HSiF6, whose respective extraction constants were determined to be log K21 = 7.42 and log K11 = 2.60. For the dissociation of hydrofluosilicic acid the activity coefficient model presented by Bromley was adapted to sulphuric acid an

The study considers relations in a group of 95 managers, 41 women and 54 men, between working climate of their units, their leadership styles in terms of their subordinates’ ratings of employee-centeredness, change-centeredness and production-centeredness, and their personality patterns according to the Spiral Aftereffect Technique (SAT). Eight managerial types were distinguished, based on low and