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The most common cause of death in pediatric cancer patients is a treatment-resistant tumor, compounded by metastatic spread, making surgery, radiation therapy, and chemotherapy unfeasible as curative treatment options. However, the mechanisms behind metastatic spread in pediatric tumors remain largely unexplored. We conducted whole-genome copy number profiling on 171 primary tumor and metastases s
In Paper I, 4703 subjects from the Malmö Cost Cancer cohort, with a mean follow-up of 16.5 years, were evaluated for future risk of ischemic stroke in relation to levels of s-LOX1. An increased risk was found for higher level of sLOX-1 OR 1.75 (1.28-2.39), p<0.001, increasing in presence of carotid plaque OR 2.42 (1.71-3.44), p<0.001. Endothelial cells were exposed to oxLDL, resulting in release o
Gas in Scattering Media Absorption Spectroscopy (GASMAS) is a near-infrared (IR) optical spectroscopy technique showing great potential in the continuous, non-invasive monitoring of the lungs. While the feasibility of GASMAS has been proven in neonatal lung studies, applying the technique to older children and adults is challenging. The increased tissue thickness strongly attenuates the signal, ne
Our current patterns of resource use have serious impact on the environment and are affecting our chances to future welfare. In this context, circular economy practices emerge as essential. Circular economy focuses on maximizing resource efficiency through reuse, repair, recycling, and product longevity—ultimately minimizing waste and reducing reliance on virgin materials. My dissertation presents
The extensive use of neonicotinoids has raised concerns about their impact on pollinators like hoverflies, which are vital for pollination and ecosystem health. This study develops and validates a green extraction method using Supercritical Fluid Extraction (SFE), coupled with HPLC (High Performance Liquid Chromatography) - MS/MS (Mass Spectrometry) for selective analysis. SFE was employed as a m
The dairy industry faces increasing demand for enhanced productivity, sustainability, and innovation. Artificial Intelligence (AI) has emerged as a transformative tool capable of addressing these challenges by enabling data-driven decision-making across the dairy supply chain. AI integrates machine learning (ML), big data analytics (DA), and predictive algorithms (PA) to optimize processes, improv
Using several melanoma proteomics data sets we created a single analysis platform that enables the discovery, knowledge build, and validation of diagnostic, predictive, and prognostic biomarkers at the protein level. Quantitative mass-spectrometry-based proteomic data was obtained from five independent cohorts, including 489 tissue samples from 394 patients with accompanying clinical metadata. We
Industries across the globe are making arduous efforts to mitigate emissions and use greener ways of transporting goods and delivering services. The supply chain includes all the activities which involve producing, transporting, and distributing goods and services, contributing to a major portion of worldwide emissions. Road transport contributes majorly to emissions; therefore, focusing on net-ze
Fuel cell electric vehicles (FCEVs) are gaining global attention as a sustainable transportation solution, yet their adoption in emerging South Asian economies remains limited. This study addresses the research gap by identifying and prioritizing barriers to FCEV adoption in India, Pakistan, and Bangladesh, regions underrepresented in existing literature. A hybrid methodology integrating Explorato
Urban expansion has led to ever increasing noise and light pollution, which impairs the audio-visual perception of wild animals and drives changes in key activities and behaviours. Nocturnal predators may be especially affected in detecting prey, with potentially dramatic consequences for their fitness. However, the combined effects of noise and light pollution on predator performance are still mo
Hemispheric asymmetry is a universal property of brain organization with wide implications into brain function and structure, and diseases. This study presents a laterality index for characterizing hemispheric asymmetries that underlie cortical maps using geometric eigenmodes derived from human cortical surfaces. We develop a generalized design to quantify asymmetries across various cortical spati
The present study investigates the integration of Lean and Sustainable manufacturing (LSM) practices to improve the market competitiveness of Indian manufacturing organizations. The study aims to explore the critical role of stakeholder commitment to drive both sustainable manufacturing and lean practices with their impact on manufacturing competitiveness. In the study a survey-based approach was
Aims: The objective of this study was to compare the risk of developing type 1 diabetes in individuals with celiac disease, hyperthyroidism and hypothyroidism to that of individuals without those conditions. Materials and Methods: In this retrospective, observational, matched-cohort study based on real-world claims data, individuals with at least one diagnosis of celiac disease, hyperthyroidism (e
Vital to the economy, culture and landscape of many regions around the world, the olive sector faces significant challenges, including rising production costs, labour shortages, climate change impacts, water scarcity, quality control issues and market demands for transparency and authenticity. Digital and other Industry 4.0 technologies offer transformative potential to address these pressures. Th
Currant, and in particular blackcurrant, Ribes nigrum, is widely grown in Europe. It is the host of a number of pest insects, but their occurrence and the damage they cause vary geographically. In northern Europe, three lepidopteran species, the currant shoot borer (Lampronia capitella), the currant clearwing (Synanthedon tipuliformis), and the currant bud moth (Euhyponomeutoides albithoracellus),
