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Infant Acute Lymphoblastic Leukemia (ALL) driven by the KMT2A::AFF1 onco-fusion is an aggressive, poor prognosis disease with few co-operative mutations. The fusion originates in utero, yet the embryonic initiating steps of disease development remain poorly understood. Here, we present a novel murine KMT2A::AFF1 model, that provides key insights into KMT2A::AFF1 pre-leukemia, relevant to human dis

BackgroundAirway hyperresponsiveness (AHR), a key feature of asthma, leads to airway narrowing in response to bronchoconstrictor stimuli. Notably, AHR is also observed in individuals with chronic obstructive pulmonary disease (COPD). The Mannitol challenge test is an indirect method to assess airway hyperresponsiveness.ObjectiveThe primary aim of this study was to explore airway hyperresponsivenes

Background and purpose — Traditional surgery forarthritis of the distal radioulnar joint (DRUJ), which typicallyinvolves resecting the ulnar head, is being increasingly challengedby newer techniques, such as prosthetic ulnar headreplacement. The aim of our prospective cohort study was toinvestigate the clinical and patient-reported functional results,up to 2 years postoperatively, among patients w

INTRODUCTION: We investigated the natural history of the relationship between PSA at age 60 and lifetime risk of prostate cancer death in an unscreened cohort followed for 40 years, the Malmö Preventive Project. We also investigated whether percent free PSA could risk-stratify men with low PSAs.METHODS: The cohort included 1162 men aged 58-62 at blood draw in 1981-82, with 1151 deaths by December

IMPORTANCE: Repeating a prostate-specific antigen (PSA) test after an elevated measurement is a guideline-recommended component of the prebiopsy workup. However, it is unclear whether certain patients can be exempted from repeat PSA testing and proceed directly to further workup.OBJECTIVE: To determine yearly PSA variability and implications of repeating an elevated PSA in the Prostate, Lung, Colo

After the clinical implementation of amyloid-β-targeting therapies for people with cognitive impairment due to Alzheimer's disease (AD), there is an urgent need to efficiently identify this patient population in primary care. Therefore, we created a brief and self-administered digital cognitive test battery (BioCog). Based on its sub-scores, a logistic regression model was developed in a secondary

INTRODUCTION: Inflammation is integral to wound healing; yet, its dynamics in normally healing epidermal wounds are not fully characterized. To this end, we analyzed longitudinal wound fluid samples collected from epidermal suction blister wounds in healthy volunteers.MATERIALS AND METHODS: A total of 48 control wounds were induced by suction blister method in 24 healthy volunteers-1 on each thigh

Objectives:To determine the cumulative live birth rate (CLBR) under three consecutive in vitro fertilisation (IVF) treatments in women with endometriosis and/or adenomyosis.Methods:A prospective cohort study of 1035 women aged 25–≤39 years undergoing up to three consecutive IVF treatments between January 2019 and April 2024. All women underwent an advanced transvaginal ultrasound examination prior

Ante el incremento continuo desde 2015 del número de personas desplazadas por la fuerza y el declive de las fuentes tradicionales de financiamiento público destinadas a la ayuda humanitaria, que ha culminado con el desmantelamiento de la Agencia de Estados Unidos para el Desarrollo Internacional (USAID), ha surgido la necesidad de buscar soluciones innovadoras para financiar las respuestas a los d

The emergence of antibiotic resistance necessitates effective strategies for evaluating antimicrobial agents. Bioluminescent bacteria, either naturally occurring or engineered with modified reporter genes like bacterial luciferase, provide real-time assessment of bacterial viability through light emission. We investigated the antibacterial effects of cefotaxime and doxycycline using bioluminescent

The roundtable brings together four authors, and a former journal editor, from the recent JCMS 20th Anniversary Symposium and forthcoming Cooperation and Conflict Anniversary Special Issue to discuss: What does the Arrival of planetary politics tell us about the European Union and normative power in the planetary organic crisis?Ian Manners provides a reflection and prospective intervention on the

Research on climate change obstruction has often focused on what has been called the Climate Change Countermovement, the CCCM. While the term originated from the social movements literature – acknowledging the movement-countermovement dynamics – it has in climate obstructionist research often been described as a relatively fixed entity connected to the vested interests of the fossil fuel industry

BACKGROUND: While patients with post-COVID syndrome (PCS) suffer from cognitive deficits few studies directly compare patients with PCS to subjects recovered after an infection with the 'Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)'.OBJECTIVES: To investigate cognitive performance adjusting for age, increasing body-mass-index (BMI), smoking, years of education, gender and hospitali

My research centres on a topic that will be familiar to many of you – namely the proliferation of paperwork and documentation demands that characterises work in many contemporary organisations. More specifically, I take as my point of departure a crux from the Swedish education sector, namely that there is a broad will – from actors at all levels of the schooling system – politicians, the Swedish

STUDY QUESTIONDoes endometriosis and/or adenomyosis, diagnosed using the International Deep Endometriosis Analysis (IDEA) group and the Morphological Uterus Sonographic Assessment (MUSA) group revised definitions, impact cumulative live birth rates (CLBR) after three consecutive IVF or ICSI treatments?SUMMARY ANSWERWomen with endometriosis and/or adenomyosis, as diagnosed using transvaginal ultras

PurposeBlood culture collection with all bottles filled from a single venipuncture (single-sampling strategy, SSS) is increasingly used. More data on the effects of SSS on blood culture contamination is needed. After combined implementation of SSS and initial specimen diversion (ISDT) in our region, we evaluated the proportion of sampling events with at least four bottles, with growth of relevant

Individuals with chronic lymphocytic leukemia (CLL) face an increased risk for severe COVID-19. This study from Sweden, a country that only had a few mandatory restrictions at the onset of the pandemic, used 10 nationwide registers to compare the risks for severe COVID-19 outcomes of polymerase chain reaction-verified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections through