Coordination of apical constriction in epithelial sheets is a fundamental process during embryogenesis. Here, we show that DRhoGEF2 is a key regulator of apical pulsation and constriction of amnioserosal cells during Drosophila dorsal closure. Amnioserosal cells mutant for DRhoGEF2 exhibit a consistent decrease in amnioserosa pulsations whereas overexpression of DRhoGEF2 in this tissue leads to an

Objective: To determine whether preterm birth is associated with epilepsy in a national cohort of adults aged 25-37 years. Methods: We conducted a national cohort study of 630,090 infants born in Sweden from 1973 through 1979, including 27,953 born preterm (< 37 weeks), followed from 2005 to 2009 for 1) hospitalization for epilepsy and 2) outpatient and inpatient prescription of antiepileptic drug

Overwash is the flow of water and sediment over the crest of a beach system when the runup level of waves or the water level, often enhanced by storm surge, exceeds the local beach or dune crest height. The impacts of overwash on coastal barriers or low lying mainland coasts are striking. Overwash may cause deposition of sand on and landward of the beach crest, large fan shaped deposits on back ba

A new method to accurately estimate the interaction energy between a large molecule and a smaller ligand is presented. The method approximates the electrostatic and induction contributions classically by multipole and polarizability expansions, but uses explicit quantum-mechanical fragment calculations for the remaining (nonclassical) contributions, mainly dispersion and exchange repulsion. Thu

Fluence-response curves were obtained at nine wavelengths in the interval 280--360 nmformRNAtranscripts of four molecular markers induced by ultraviolet-B (UV-B) radiation in Arabidopsis thaliana (L.) Heynh.: CHS (encoding chalcone synthase), PDX1.3 (encoding an enzyme involved in formation of pyridoxine), MEB5.2 (encoding a protein with unknown function but which is strongly upregulated by UV-B),

Aims. The detection and measurement of gravitational-waves from coalescing neutron-star binary systems is an important science goal for ground-based gravitational-wave detectors. In addition to emitting gravitational-waves at frequencies that span the most sensitive bands of the LIGO and Virgo detectors, these sources are also amongst the most likely to produce an electromagnetic counterpart to th

Block copolymers dissolved in selective solvent often self-assemble. We review the use of NMR to Study this process and to characterize the aggregates formed. We stress the need to consider the polydispersity of the polymers and the fact that the increase in NMR relaxation rates observed upon aggregation can be assigned to contributions from the block copolymer micelle tumbling. (C) 2008 Elsevier

Based on the chiral perturbation theory, we investigate the low-energy dynamics of nucleon parton distributions. We show that in different regions of the momentum fraction x the chiral expansion is significantly different. For nucleon parton distributions these regions are characterized by x similar to 1, x similar to m(pi)/M-N and x similar to (m(pi)/M-N)(2). We derive extended counting rules for

In a recent publication, Feng et al. [Feng et al., Nat. Mater., 2015, 14, 61] reported a very interesting re-entrant solidification behaviour of colloidal particles in an aqueous solution containing polyethylene oxide (PEO). In this system, a crystalline colloidal phase, which is present at low temperatures, melts to a homogeneous fluid upon increasing the temperature. Further raising the temperat

Background: Lung cancer is the worldwide leading cause of death from cancer. Tobacco usage is the major pathogenic factor, but all lung cancers are not attributable to smoking. Specifically, lung cancer in never-smokers has been suggested to represent a distinct disease entity compared to lung cancer arising in smokers due to differences in etiology, natural history and response to specific treatm

Dizziness in older people is associated with disability and reduced quality of life. Few studies have investigated how daily life is affected from the older person's perspective. Identifying barriers and resources in daily life could guide health care in how to direct efficient interventions. The aim of this study was to explore older persons' experiences of living with chronic dizziness.

Stroke and in this case cerebral infarction affects 20 million people each year and five million of them die. In Sweden 30-35000 people will be affected and one of three of them will be severely disabled. In addition, one of six will suffer a new stroke within six years. The cause of stroke is usually a vessel in the brain that is blocked, resulting in massive neuronal cell death. Since treatment

Diabetes mellitus is a disease characterized by increased blood glucose levels. For overt type 2 diabetes to develop, both insulin action and insulin secretion must be perturbed. In the work presented in this thesis, two models were analyzed: hormone-sensitive lipase (HSL) null mice and a pancreatic clonal β-cell line to study the mechanisms underlying insulin resistance and insulin secretion pert

Purpose Timely knowledge of the bacterial etiology and localization of infection are important for empirical antibiotic therapy. Thus, the goal of this study was to evaluate routinely used biomarkers together with novel laboratory parameters in the diagnosis of infection. Methods In this prospective study, 54 adult patients with bacterial infections admitted to the Department of Infectious Disease

Three weakly populated high-spin rotational bands associated with the gamma decay of Er-159 and Er-160 were observed in fusion-evaporation reactions involving a beam of Ca-48 at an energy of 215 MeV incident on a Cd-116 target. The gamma decays were detected using the highly efficient Gammasphere spectrometer. The discovery of these bands, which extend discrete-line spectroscopy in these nuclei to

This is a brief review of the second, slightly revised and expanded edition of a book that appeared for the first time in Swedish in 1993.

Endovascular treatment had developed rapidly and the procedures have increased in complexity. The demand of imaging excellence is imperative to perform these interventions. However both pre and postoperative investigations are performed by the use of advanced three-dimensional imaging, while the treatment itself relies on two-dimensional imaging. With the use of Cone Beam Computed Tomography (CBCT

The phenyldi(2-thienyl)phosphine (PhPTh2) complexes [Os-3(CO)(12-n)(PhPTh2)(n)] (n = 1-3) (1-3) have been prepared. Thermolysis of 1 and either 2 or 3 in octane affords carbon-hydrogen bond activation products [Os-3(CO)(9){mu(3)-PPhTh(C4H2S)}(mu-H)] (4) and [Os-3(CO)(8)(PPhTh2){mu(3)-PPhTh(C4H2S)}(mu-H)] (5), respectively. Both exist as isomeric mixtures differing in the relative positions of phen

Purpose Little is known about the interaction between job control and social support at work on common mental disorders. To examine whether there is a synergistic interaction effect between job control and social support at work on general psychological distress and whether it differs by the level of job demands. Methods About 1,940 male and female workers from the Malmo Shoulder and Neck Study we

A recently developed protocol for pulsed gradient spin echo (PGSE) NMR is applied for the size determination of multilamellar vesicles (MLVs). By monitoring the self-diffusion behavior of water, the technique yields an estimate of the homogeneous length scale λ(hom), i.e. the maximum length scale at which there is local structural heterogeneity in a globally homogeneous material. A cross-over betw