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Photopatterning of self assembled monolayers on oxide surfaces for the selective attachment of biomolecules

The immobilization of functional biomolecules to surfaces is a critical process for the development of biosensors for disease diagnostics. In this work we report the patterned attachment of single chain fragment variable (scFv) antibodies to the surface of metal oxides by the photodeprotection of self-assembled monolayers, using near-UV light. The photodeprotection step alters the functionality at

Effects of growth conditions on the crystal structure of gold-seeded GaP nanowires

we present results that provide fundamental insights on how to experimentally tailor the planar defect density and even the crystal structure in III-V metal-particle-seeded nanowires, where zinc blende is the stable bulk crystal structure. We have grown GaP nanowires with metal-organic vapor-phase epitaxy under different conditions: pulsing of the Ga source, and Continuous growth with and without

Drugs and Birth Defects: a knowledge database providing risk assessments based on national health registers

To present concept, methods and use of a knowledge database providing assessments of potential fetal risks for all drugs on the Swedish market. Assessments of fetal risks are made primarily by analyzing prospective epidemiological data from the Swedish Medical Birth Register on drug intake in relation to birth outcome. This is complemented by evaluation of the scientific literature. Following stan

“Striden ägde rum i Malmö”: Möllevångskravallerna 1926. En studie av politiskt våld i mellankrigstidens Sverige.

During a few days at the end of November 1926, the Möllevången neighborhood in Malmö was the scene of violent confrontations between thousands of demonstrators and a large part of the city police force. Behind these demonstrations lay an industrial conflict, begun early in July that year at A. W. Nilsson factory. The workers went on strike, and a week or so later the factory owner employed a local

Upregulation of miR-96 Enhances Cellular Proliferation of Prostate Cancer Cells through FOXO1.

Aberrant expression of miR-96 in prostate cancer has previously been reported. However, the role and mechanism of action of miR-96 in prostate cancer has not been determined. In this study, the diagnostic and prognostic properties of miR-96 expression levels were investigated by qRT-PCR in two well documented prostate cancer cohorts. The miR-96 expression was found to be significantly higher in pr

Investigation of lead concentrations in whole blood, plasma and urine as biomarkers for biological monitoring of lead exposure

Lead in blood is a major concept in biomonitoring of exposure but investigations of its alternatives are scarce. The aim of the study was to describe different lead biomarkers' variances, day-to-day and between individuals, estimating their fraction of the total variance. Repeated sampling of whole blood, plasma and urine were conducted for 48 lead-exposed men and 20 individuals under normal envir

The HCCI Fuel Number - Measuring and Describing Auto-ignition for HCCI Combustion Engines

Popular Abstract in Swedish Att mäta och beskriva självantändning vid förblandad kompressionsantändning (HCCI) HCCI-förbränning går ut på att luft och bränsle blandas, och komprimeras i en kolvmotor tills blandningen självantänder. På grund av den snabba förbränningen med det här konceptet förloras mindre värmeenergi, och verkningsgraden blir därför högre än för vanliga bensin- och dieselmotorer. HCCI is an advanced combustion concept, using premixed fuel and air with a diluted charge. This is thermodynamically favorable, leading to high efficiency and therefore lower CO2 emissions. The well-premixed and diluted fuel charge gives lower cylinder temperatures than conventional diesel compression ignition and spark ignited gasoline combustion, resulting in low engine out emissions of both nit

The energy-selective option in neutron imaging

In the past, neutron imaging investigations have been mostly performed in "integrating mode", which averages over the full applied neutron energy spectrum. This article describes four different methods and devices of obtaining energy selectivity in the thermal to cold energy range, which allow a new approach in neutron imaging. Two principles have been used and tested: (a) selection of neutrons by

Effect of thermal exposure on microstructure and nano-hardness of broached Inconel 718

Inconel 718 is a high strength, heat resistant superalloy that is used extensively for components in hot sections of gas turbine engines. This paper presents an experimental study on the thermal stability of broached Inconel 718 in terms of microstructure and nano-hardness. The broaching process used in this study is similar to that used in gas turbine industries for machining fir-tree root fixing

Does duration on antiretroviral therapy determine health-related quality of life in people living with HIV? A cross-sectional study in a regional referral hospital in Kenya.

Objective : To measure the extent to which health-related quality of life (HRQoL) in people living with HIV is associated with duration of antiretroviral therapy (ART) after controlling for sociodemographic, clinical, and other therapy-related factors. Design : Cross-sectional analysis. Methods : A gender-stratified random sample of 421 participants aged 18-64 years was selected from the patients

High Affinity Antibodies to Plasmodium falciparum Merozoite Antigens Are Associated with Protection from Malaria

Background: Malaria kills almost 1 million people every year, but the mechanisms behind protective immunity against the disease are still largely unknown. Methodology/Principal Findings: In this study, surface plasmon resonance technology was used to evaluate the affinity (measured as kd) of naturally acquired antibodies to the Plasmodium falciparum antigens MSP2 and AMA1. Antibodies in serum samp

Many-body effects on tracer particle diffusion with applications for single-protein dynamics on DNA

30% of the DNA in E. coli bacteria is covered by proteins. Such a high degree of crowding affects the dynamics of generic biological processes (e.g. gene regulation, DNA repair, protein diffusion etc) in ways that are not yet fully understood. In this paper, we theoretically address the diffusion constant of a tracer particle in a one-dimensional system surrounded by impenetrable crowder particles

Observations of Host Guest Interactions Specific to Molecular Matrices: Water Monomers and Dimers in Hydrogen Matrices.

Water monomers and dimers have been studied at low temperatures in matrices of solid p-H(2), o-D(2), n-H(2), and n-D(2) using infrared spectroscopy. Our data demonstrate interaction mechanisms between host matrix and guest molecules that are different from the ones observed in atomic noble gas matrices. Notably both guest/host rotational-rotational interaction and matrix induced modifications of t

Dual Effect of Amino Modified Polystyrene Nanoparticles on Amyloid beta Protein Fibrillation

The fibrillation kinetics of the amyloid beta peptide is analyzed in presence of cationic polystyrene nanoparticles of different size. The results highlight the importance of the ratio between the peptide and particle concentration. Depending on the specific ratio, the kinetic effects vary from acceleration of the fibrillation process by reducing the lag phase at low particle surface area in solut

Kartan som spegling och produktion av rumslighet

The map is not simply a representation of existing space, or a mirror of the earth’s surface. It is rather a multi-faceted instrument expressing that the power to represent is the power to order, and that the rationality of geometrical space could influence people’s lived spaces through its role as a planning tool. These issues are discussed with three examples from Swedish modernity; the producti