Several common genetic variations have been associated with type 2 diabetes, but the exact disease mechanisms are still poorly elucidated. Here, using congenic strains from the diabetic GK-rat, we identified a 1.4-Mb genomic locus that was linked to impaired insulin granule docking at the plasma membrane and reduced beta cell exocytosis. In this locus, Adra2a, encoding the alpha2A-adrenergic recep

Recurrent prostate cancer (PCa) remains a major clinical challenge. Invasive and metastatic PCa lesions often exhibit a partial and time-limited response to therapy before the cancer progresses and the patient succumbs to the disease. Despite recent advances in early diagnosis and treatment, approximately one-third of treated patients will relapse and become resistant to currently available treatm

Objective: To investigate the impact of a reminder (i.e., a mailed letter or short telephone call) from the pharmacy to patients, compared with no reminder in a control group, on the pick-up rates of unclaimed e-prescriptions. Method: Patients, with e-prescriptions transmitted to four large community pharmacies in two counties in northern Sweden and remaining unclaimed after 4 weekdays, were rando

The standard procedure for photopatch testing includes 24-h occlusion of the allergen, followed by irradiation at 5 J/cm2 ultraviolet A (UVA). Due to the timing, a separate visit to the clinic is needed for UV irradiation. The aim of this study was to determine whether a reduction in occlusion time from 24 h to 1 h, in order to simplify the testing procedure, influences test results when photopatc

Popular Abstract in Swedish Vår värld drivs av förbränning. Från den lilla elden som används vid matlagning till gigantiska gasturbiner och kolkraftverk som genererar en stor del av all elektricitet. Dessutom så drivs nästan alla fordon av förbränningsmotorer. Det har uppskattats att över nittio procent av alla energi vi i världen omvandlar kommer från förbränning i någon form. Det är således ganHigh repetition rate laser diagnostics has proven to be a useful tool for studying combustion phenomena. Laser techniques are, in general, relatively non-intrusive and have the potential to measure specific species at very low concentrations and with extremely high temporal resolution. However, most laser systems in this field of research are limited to repetition rates below 100 Hz, and are thus

"Göteborgskravallerna skadade demonstranters demokratisyn". I Göteborgskravallerna för, i dag, fem år sedan deltog en stor grupp mycket politiskt engagerade unga människor. De förlorade sin tro på det politiska systemet, skriver en grupp forskare. Den globala rättviserörelsens aktivister är betydligt mer politiskt aktiva än befolkningen som helhet och har högre valdeltagande, skriver forskarna so

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Sixty-one adult patients (34 men and 27 women) who were operated on for unilateral complete cleft lip and palate (UCLP) were followed up from 1996-2001 by clinical investigation, perceptual speech analysis, and self-estimation of quality of speech. Thirty-four had had a von Langenbeck repair at the age of 8 months (L-8 group), and 27 a Wardill repair at the age of 18 months (W-18 group). Statistic

The aims of this article are to consider (1) whether there are medical and societal differences among diseases regarding which patient groups should be asked to participate in first-in-human (FIH) trials of stem-cell-based therapies; (2) any differences in the light of values generally endorsed by different types of ethical theories, since the question in the title of this article is value laden,