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Traumatic brain injury (TBI) has been shown to activate the peripheral innate immune system and systemic inflammatory response, possibly through the central release of damage associated molecular patterns (DAMPs). Our main purpose was to gain an initial understanding of the peripheral mitochondrial response following TBI, and how this response could be utilized to determine cerebral mitochondrial

Mounting evidence from proxy records suggests that variations in solar activity have played a significant role in triggering past climate changes. However, the mechanisms for sun-climate links remain a topic of debate. Here we present a high-resolution summer sea-surface temperature (SST) record covering the past 9300 yr from a site located at the present-day boundary between polar and Atlantic su

Cnidarians are often used as model animals in studies of eye and photopigment evolution. Most cnidarians display photosensitivity at some point in their life-cycle ranging from extraocular photoreception to image formation in camera-type eyes. The available information strongly suggests that some cnidarians even possess multiple photosystems. The evidence is strongest within Cubomedusae where all

The number of applications sharing the same embedded device is increasing dramatically. Very efficient mechanisms (resource managers) for assigning the CPU time to all demanding applications are needed. Unfortunately, existing optimization-based resource managers consume too much resource themselves. In this paper, we address the problem of distributed convergence to fair allocation of CPU resourc

Chondroitin sulfate (CS) and dermatan sulfate (DS) are expressed in significant amounts in the brain and play important roles in the development of the central nervous system in mammals. CS and DS structures are often found in a single CS/DS hybrid chain. The L-iduronic acid (IdoA)-containing domain, which defines a DS-type domain, appears key to the biological functions of the CS/DS hybrid chain.

This PhD thesis deals with the transformation of imported vessels of Roman origin in Germania Magna during the Roman Iron Age, 1-400 AD. The concept of transformation in this context refers to the various ways these objects were interpreted, physically altered and consequently changed with regard to their function and meaning. Roman vessels in Germanic contexts are often regarded as evidence for R

Den här artikeln redovisar resultaten från ett experiment av Holm och Runnemark 2013) som belyser hur ett paket mjölk påverkar utfallet i en förhandling genom att jämföra det med utfallet i en förhandling om en hypotetisk vara.Genom att beskriva förhandlingen som en situation där köpare och säljare ska förhandla om en faktiskt vara berör experimentet också frågan om betydelsen av abstrakta beskriv

Strategies for expanding hematopoietic stem cells (HSCs) include coculture with cells that recapitulate their natural microenvironment, such as bone marrow stromal stem/progenitor cells (BMSCs). Plastic-adherent BMSCs may be insufficient to preserve primitive HSCs. Here, we describe a method of isolating and culturing human BMSCs as nonadherent mesenchymal spheres. Human mesenspheres were derived

Popular Abstract in Swedish Under 1700- och 1800-talet omvandlades det svenska jordbruket som en del av en euro¬peisk utveckling som uppvisar övergripande likheter. De genomgripande förändringarna och deras betydelse för den långsiktiga samhällsutvecklingen motiverar att man talar om en agrar revolution. Trots övergripande likheter rymde emellertid den agrara revolutionen såväl regio-nala som lokaThe great transformation of Swedish agriculture in the 18th and 19th centuries was part of a European-wide development sharing similar characteristics. While researchers agree that extensive agro-technological, social and institutional changes took place, opinions differ with regards to the causes, spread, timing and sequence of events. Through a systematic study of agricultural production, land u

Popular Abstract in Swedish I min avhandling har jag tittat på möjligheten att göra om mänskliga hudceller direkt till dopaminerga nervceller. Dessa uppvisar flera egenskaper tillskrivna de dopaminerga nervceller vi hittar i hjärnan. Jag tittar även på möjligheten att transplantera dessa som hudceller i hjärnan på råttor och sen göra om dom till nervceller när de är på plats. Dessa celler bildar nCellular reprogramming is when one cell is changed into another. This involves structural modifications on the DNA of a cell resulting in a transcriptional change. This occurs naturally during development when early pluripotent cells gradually differentiate into more specialized cells that finally result in a complete organism. This is a finely orchestrated event that includes both extrinsic and i

A mathematical model, based on branching processes, is proposed to interpret BrdUrd DNA FCM-derived data. Our main interest is in determining the distribution of the G2 phase duration. Two different model classes involving different assumptions on the distribution of the G2 phase duration are considered. Different assumptions of the G2 phase duration result in very similar distributions of the S p

Background: In recent years, several primary care databases recording information from computerized medical records have been established and used for quality assessment of medical care and research. However, to be useful for research purposes, the data generated routinely from every day practice require registration of high quality. In this study we aimed to investigate (i) the frequency and vali

Understanding polymorphism in pharmaceutical ingredients is a long-standing challenge in formulation science. A well-known example is paracetamol, C8H9NO2. The marketed stable form I crystallizes with corrugated molecular layers. In contrast, form II, which is thermodynamically favorable at high pressures, has relatively planar layers that can slip over each other without difficulty, but is metast

Background: Despite a decreasing incidence of peptic ulcer disease, most previous studies report a stabile incidence of ulcer complications. We wanted to investigate the incidence of peptic ulcer complications in Sweden before and after the introduction of the proton pump inhibitors (PPI) in 1988 and compare these data to the sales of non-steroid anti-inflammatory drugs ( NSAID) and acetylsalicyli

An article about city fires.

There is a lack of detailed information on the impact of organic feeding regulation on the health and well-being of cows. This has become especially important since January 2008 when the EU required 100% organic ration for organic dairy herds. The aim of this investigation was to determine and compare the levels of essential elements in organic and conventional dairy herds, and to associate them w

Purpose To compare drug treatment changes in older hip fracture patients with and without multi-dose drug dispensing (MDD) after discharge from hospital. Methods Hip fracture patients (aged 65 years or older) for whom the same prescribing procedure was used at discharge and at the 6-month follow-up were extracted from two patient cohorts consecutively recruited in 2008 (n=100) and 2009 (n=99), res