Low oxygen pressure (hypoxia) is a physiological condition that has been linked to tumor progression and increased malignancy in several cancer forms. Cells of the childhood neoplasm neuroblastoma respond to hypoxia by attaining a lower grade of differentiation, which clinically is associated with poor prognosis. Furthermore, expression of the hypoxia inducible factor-2alpha correlates to poor out

This study investigated the predictors of aerobic fitness (VO2PEAK) in young children on a population-base. Participants were 436 children (229 boys and 207 girls) aged 6.7 ± 0.4 yrs. VO2PEAK was measured during a maximal treadmill exercise test. Physical activity was assessed by accelerometers. Total body fat and total fat free mass were estimated from skinfold measurements. Regression analyses i

Objectives. We sought to study the relationship between left ventricular ejection fraction (LVEF) and infarct size in patients with ischemic heart disease (IHD) using magnetic resonance imaging (MRI), and to determine a dysfunction index based on the maximum possible LVEF in relation to infarct size. Design. In 149 patients with chronic IHD, LVEF and infarct size were quantified by MRI. Dysfunctio

A very critical review of Henrik Jacobsens dissertation in medieval archaeology, "Romanske vesttårne, deres indretning og funktion. Vesttårne før 1300 i det middelalderlige Danmark øst for Storebælt" (Stockholm 1993). Alternative explanations are proposed.

BACKGROUND.: Everolimus reduces the progression of cardiac allograft vasculopathy (CAV) in de novo heart transplant (HTx) recipients, but the influence on established CAV is unknown. METHODS.: In this Nordic Certican Trial in Heart and lung Transplantation substudy, 111 maintenance HTx recipients (time post-HTx 5.8±4.3 years) randomized to everolimus+reduced calcineurin inhibitor (CNI) or standard

Popular Abstract in Swedish Behövs en gemensam offentlig sfär i Europa för att EU:s beslutsprocess ska kunna anses vara demokratiskt legitim – och hur skulle en sådan europeisk offentlig sfär kunna se ut? Mot bakgrunden av debatten om EU:s demokratiska underskott undersöker denna studie vilken roll dagstidningar spelar i skapandet av transnationella debattarenor. Specifikt undersöker studien om enWhat kind of public sphere is possible in the European Union? Against the backdrop of debates on the transformation of democracy beyond the nation-state, this study explores daily newspapers’ role in providing forums for transnational debate in the presumed absence of an overarching European collective identity. It uses empirical means to reconsider the question of the supposed co-constitutiveness

Aim: The aim of this study was to evaluate if a general school-based exercise intervention programme in pre-pubertal boys would render site-specific benefits in bone mineral accrual and gain in femoral neck structure. Methods: Eighty boys aged 7-9 years were included in a curriculum-based exercise intervention programme comprising 40 min of general physical activity per school day (200 min/week) f

Compared to most other countries in the world, many of the European countries are highly secularized in the sense that only low shares of the population now adhere to the traditional church-oriented religion. In particular, Sweden is often described as one of the most secularized countries in the world. Sociologists of religion differ in their assumptions about the causes of the secularization pro

This article explores the notion of borderlands as ambivalent and contested landscapes, as literal and figurative in-between spaces—realms of negotiation, translation and remaking. It is argued that, due to the social and cultural processes taking place in borderlands, they can be usefully scrutinized using concepts developed in postcolonial scholarship. In particular, Homi Bhabha’s concept of the

Distributions of wave characteristics of ocean waves, such as slope, amplitude or wavelength, are an important tool in the study of ship stability. In such studies, spatial properties of the sea surface at fixed time points are often considered, although it would be more interesting to study the properties of those waves that a ship actually encounters when it sails on the ocean. In this paper we

BACKGROUND: Impaired oxidative capacity of skeletal muscle mitochondria contribute to insulin resistance and type 2 diabetes (T2D). Furthermore, mRNA expression of genes involved in oxidative phosphorylation, including ATP5O, is reduced in skeletal muscle from T2D patients. Our aims were to investigate mechanisms regulating ATP5O expression in skeletal muscle and association with glucose metabolis

Proton circuits across the inner mitochondrial membrane link the primary energy generators, namely the complexes of the electron transport chain, to multiple energy utilizing processes, including the ATP synthase, inherent proton leak pathways, metabolite transport and linked circuits of sodium and calcium. These mitochondrial circuits can be monitored in both isolated preparations and intact cell

Acute lung injury is a severe complication to acute pancreatitis and a significant health problem associated with a considerable mortality. Underlying mechanisms are complex and poorly understood, although recent insights have identified several inflammatory profiles and cellular components involved to varying degrees during different phases of pancreatitis exacerbation and acute lung injury. This