Our current understanding of the spread and neurodegenerative effects of tau neurofibrillary tangles (NFTs) within the medial temporal lobe (MTL) during the early stages of Alzheimer’s Disease (AD) is limited by the presence of confounding non-AD pathologies and the two-dimensional (2-D) nature of conventional histology studies. Here, we combine ex vivo MRI and serial histological imaging from 25

Background: Addressing attitudes is central to achieving sexual and reproductive health and rights (SRHR) and Agenda 2030. We aimed to develop a comprehensive index to measure attitudinal support for SRHR, expanding opportunities for global trend analyses and tailored interventions. Methods: We designed a new module capturing attitudes towards different dimensions of SRHR, collected via the nation

How to make robots safe for humans is intensely debated, within academia as well as in industry, media and on the political arena. Hardly any discussion of the subject fails to mention Isaac Asimov’s three laws of Robotics. We find it curious that a set of fictional laws can have such a strong impact on discussions about a real-world problem and we think this needs to be looked into.The probably mHow to make robots safe for humans is intensely debated, within academia as well as in industry, media and on the political arena. Hardly any discussion of the subject fails to mention Isaac Asimov’s three laws of Robotics. Asimov’s laws and the Trolley Problem are usually discussed separately but there is a connection in that the Trolley Problem poses a seemingly unsolvable problem for Asimov’s F

Translation is an essential genetic process for understanding the mechanism of gene expression. Due to the large number of protein sequences generated in the post-genomic era, conventional methods are unable to identify Translation Initiation Site (TIS) in human genes timely and accurately. It is thus highly desirable to develop an automatic and accurate computational model for identification of T

Om framväxten av forskning och högre utbildning inom EU.

This article analyzes Paul Celan’s translation of James Baldwin’s “Everybody’s Protest Novel” and considers the connections between the poetics of these two writers. In addition to their shared preoccupation with and rearticulation of terms such as human, creature, and darkness, the translation reveals how they explored the relationship between literature and reality at early and transitional mome

This paper studies the sources of the Russia–Ukraine conflict. The prerequisites for this conflict began when, in Ukraine and Russia, the liberal tendencies that emerged after the collapse of the USSR gave way to conservatism. The differences between the current state ideologies of the two countries are demonstrated through a comparative analysis of 16 Russian and Ukrainian school history and lite

Philosophy played an important role in the Soviet political system becauseit provided ideological legitimization for the regime. Therefore, throughout the existence of the Soviet Union, the authorities and general populations showed a great interest in the works of philosophers. The collapse of the Soviet Union and its Marxist-Leninist ideology led to philosophy’s losing its privileged political s

BACKGROUND: MicroRNAs (miRNAs) are sought-after biomarkers of complex, polygenic diseases such as type 2 diabetes (T2D). Data-driven biocomputing provides robust and novel avenues for synthesizing evidence from individual miRNA seq studies.OBJECTIVE: To identify miRNA markers associated with T2D, via a data-driven, biocomputing approach on high throughput transcriptomics.MATERIALS AND METHODS: The

The field of learned image compression has been facing rapid development and research engagement. In this thesis, we seek to make an addition to the field by extending a state-of-the-art learned image compression architecture, called LIC-TCM, by incorporating a depth map as a second complementary modality to further enhance the image compression. Furthermore, we explore the inverse, meaning we pri

Myanmar’s unofficial minorities encompass diverse religious and ethnic groups excluded from Myanmar’s list of 135 officially recognised “national races.” They face exclusion due to their citizenship status as well as societal prejudices and entrenched discrimination against minority communities. Yet, debates over politics, federalism, and power-sharing in Myanmar primarily concern the relationship

We investigated the sequential protein expression in gingival crevicular fluid samples during the induction (I) and resolution (R) of experimental gingivitis. Periodontally and systemically healthy volunteers (n = 20) participated in a three-week experimental gingivitis protocol, followed by debridement and two weeks of regular plaque control. Gingival crevicular fluid (GCF) samples were collected

In the search for neutron antineutron oscillations (n → ̄n) in the proposed 200m long NNBAR beamline, it is imperative that the pions originating from the antineutron annihilation events can be detected outside of the vacuum chamber. The purpose of the design of the vacuum chamber then becomes to minimise the effect of the chamber while also adhering to the requirements of the pressure vessels. To

This chapter presents the notion of spatial justice as a way of considering the relationship between law and street art in a manner beyond the legal/illegal dichotomy. Through a series of empirical examples, it is demonstrated how street art literally takes a place already taken and imposes itself in an already appropriated urban public space. Street art thus ´redefines the space in contestation t

Our current historical moment is marked by a widespread sense of (ongoing and anticipated) crises, prompting calls to change existing economic, political, social, and environmental systems. This discourse has directed increased scholarly and policy-orientated attention to the concepts of “transformation” and “resilience.” However,beyond attention, these concepts have increasingly adopted a place iOur current historical moment is marked by a widespread sense of (ongoing and anticipated) crises, prompting calls to change existing economic, political, social, and environmental systems. This discourse has directed increased scholarly and policy-orientated attention to the concepts of “transformation” and “resilience.” However, beyond attention, these concepts have increasingly adopted a place

BACKGROUND: Currently, there are few treatment-predictive and prognostic biomarkers in triple-negative breast cancer (TNBC). Caveolin-1 (CAV1) is linked to chemoresistance and several important processes involved in tumor progression and metastasis, such as epithelial-mesenchymal transition (EMT). Herein, we report that high CAV1 gene expression is an independent factor of poor prognosis in TNBC.M

To Speak or Not to Speak: A Study of Upward Critical Feedback from the Perspective of Employees in Non-Managerial Positions. The existence of critical feedback that flows from subordinates and is directed to first-order managers constitutes an insightful source of information about potential internal issues that affect an organization’s overall outcome. Therefore, the presence of a two-way dialogu

This case study of the satire conspiracy theory phenomenon Birds aren’t real, aims to contribute to the academic field of conspiracy theories. Conspiracy theories have seen a rising interest in academia in the last decade. Negative outcomes of the rapid spread of conspiracy theories and misinformation are a threat to democratic struc-tures, institutions, and values. Although the societal importanc