Background: Marfan Syndrome (MFS) has been associated with increased aortic stiffness and left ventricular dysfunction. The latter may be due to the underlying genotype and/or secondary to aortic stiffening (vascular-ventricular interaction). The aim of this study was to characterize arterial and cardiac function in MFS using a multimodal approach. Methods: Prospective observational study of MFS p

Biodiesel considered a green, environmentally friendly, and renewable energy source is one of the most promising candidates to replace fossil fuels to supply energy for the world. The conventional thermocatalytic methods have been extensively explored for producing biodiesel, while inevitably encountering some drawbacks, such as harsh operating conditions and high energy consumption. The catalytic

The artificial neural networks approach is applied to estimate the acoustic performance for airborne and impact sound insulation curves of different lightweight wooden floors. The prediction model is developed based on 252 standardized laboratory measurement curves in one-third octave bands (50-5000 Hz). Physical and geometric characteristics of each floor structure (materials, thickness, density,

Background: Maternal alloantibodies to human platelet antigen-1a can cause severe intracranial hemorrhage in a fetus or newborn. Although never evaluated in placebo-controlled clinical trials, most Western countries use off-label weekly administration of high-dosage intravenous immunoglobulin in all pregnant women with an obstetrical history of fetal and neonatal alloimmune thrombocytopenia. In No

To decrease the spread of the COVID-19 virus, public health officials in British Columbia, Canada ordered large-scale physical distancing requirements, leading to school and business closures, banning of large gatherings, and travel restrictions. These requirements shifted people’s occupational repertoires, with vulnerable populations (e.g., those with chronic health conditions) possibly being dif

Background: Pathogenic variants in KCNJ13 have been associated with both autosomal dominant Snowflake vitreoretinal degeneration (SVD) and autosomal recessive Leber congenital amaurosis. SVD is characterized by aberrant vitreoretinal interface leading to increased risk of retinal detachment, crystalline retinal snowflake deposits, optic disc abnormalities, early-onset cataract, and cornea guttae.

I avhandlingen undersöks vilka störningar i entreprenadavtal som kan ge entreprenören rätt till tidsförlängning.Med störning avses i avhandlingen en omständighet som avviker från vad entreprenören förutsatt (antagit) senast vid avgivandet av sitt löfte (anbud) att ingå avtalet som gör att entreprenörens arbeten inte kan utföras som planerat och som orsakar tillkommande kostnader, en försening elle

In terms of its total population, Sweden is one of the countries with the highest proportion of immigrants in the EU. Several factors are critical in integrating immigrants, especially their economic security in a new country. This thesis examines the relationship between law enforcement and economic security for over- indebted immigrants. The primary purpose of this research is to explore the relIn terms of its total population, Sweden is one of the countries with the highest proportion of immigrants in the EU. Several factors are critical in integrating immigrants, especially their economic security in a new country. This thesis examines the relationship between law enforcement and economic security for over- indebted immigrants. The primary purpose of this research is to explore the rel

Genom empiriska exempel från Danmark och Sverige diskuterar denna artikel hur den moderna, masstillverkade cykeln blev ett viktigt verktyg i händerna på en ny generation politiska ungdomar. Under mellankrigsåren (1918–1939) utgjorde de unga sig själva som en egen samhällsgrupp. För allra första gången i historien blev ungdomen nyckelaktörer på den politiska scenen och de tog med sig moderna former

Surface guidance systems enable patient positioning and motion monitoring without using ionising radiation. Surface Guided Radiation Therapy (SGRT) has therefore been widely adopted in radiation therapy in recent years, but guidelines on workflows and specific quality assurance (QA) are lacking. This ESTRO-ACROP guideline aims to give recommendations concerning SGRT roles and responsibilities and

Det är en myt, att de medeltida kalkmålningarna överkalkades vid reformationen. Myten lever, då det är en enkel förklaring till kontrasten mellan vitkalkade väggar och valv i exempelvis S:t Petri kyrka i Malmö och Krämarkapellets färgrika kalkmålningar i samma kyrka. Myten finner även stöd i en del litteratur och på hemsidor, trots att det är känt sedan 1800-talets slut att traditionen med kalkmålIt is a myth, that the medieval ecclesiastic wall-paintings were whitewashed during the Reformation. The myth lives on, as it is perceived as a simple explanation of the contrast between the white church walls and vaults at e.g. Saint Peter in Malmö and the colorful wall-paintings of the chapel of the vendors there. The myth also finds support in some literature and on webpages, although it has be

BACKGROUND: Physciosporin (PHY) is one of the potent anticancer lichen compound. Recently, PHY was shown to suppress colorectal cancer cell proliferation, motility, and tumorigenesis through novel mechanisms of action.PURPOSE: We investigated the effects of PHY on energy metabolism and tumorigenicity of the human breast cancer (BC) cells MCF-7 (estrogen and progesterone positive BC) and MDA-MB-231

Exposure to environmental pollutants is a major public health concern. This study investigated the inflammatory and tumorigenic effects of environmental pollutants (benzene, benzo[a]pyrene, cadmium, and diisononyl phthalate) on transformed A549 and H292 lung alveolar epithelial cells and non-transformed BEAS-2B lung bronchial epithelial cells. The cytotoxic effects of the pollutants were analyzed

BACKGROUND: Lichens, which represent symbiotic associations of fungi and algae, are potential sources of numerous natural products. Physciosporin (PHY) is a potent secondary metabolite found in lichens and was recently reported to inhibit the motility of lung cancer cells via novel mechanisms.PURPOSE: The present study investigated the anticancer potential of PHY on colorectal cancer (CRC) cells.M

Deoxypodophyllotoxin (DPT) is a cyclolignan compound that exerts anti-cancer effects against various types of cancers. DPT induces apoptosis and inhibits the growth of breast, brain, prostate, gastric, lung, and cervical tumors. In this study, we sought to determine the effect of DPT on cell proliferation, apoptosis, motility, and tumorigenesis of three colorectal cancer (CRC) cell lines: HT29, DL

Usnic acid (UA), a lichen secondary substance, has considerable anticancer activity in vitro, whereas its effect in vivo is limited. Here, potassium usnate (KU) was prepared by the salinization of UA to enhance its water solubility. KU showed increased bioavailability compared with UA in the tumor, liver, and plasma of a CT26 syngeneic mouse tumor xenograft model after oral administration, as dete