Gastric cancer is a dominating cause of cancer-associated mortality with limited therapeutic options. Here, we show that syndecan-4 (SDC4), a transmembrane proteoglycan, is highly expressed in intestinal subtype gastric tumors and that this signature associates with patient poor survival. Further, we mechanistically demonstrate that SDC4 is a master regulator of gastric cancer cell motility and in

This master thesis invites the reader to acquire and examine new evidence about an emerging and growing sub-genre type of documentary film called Ayahuasca documentary. This study bases its definition of the Ayahuasca documentary sub-genre on a current work in the progress catalogue of over 50 documentary films, two of which were selected as case studies. These films suggest a growing cultural int

Access to safe drinking water and sanitation is a given standard and considered as basic human rights in urban areas and industrialized countries. However, 40 % of the world's population living in rural areas in developing countries lack access to safe drinking water. Many ongoing projects are focused on providing safe drinking water and sanitation in rural areas, including Hamro Paani. Hamro

Micro- and nanoplastic pollution has emerged as a global environmental problem. Moreover, plastic particles are of increasing concern for human health. However, the detection of so-called nanoplastics in relevant biological compartments remains a challenge. Here we show that Raman confocal spectroscopy-microscopy can be deployed for the non-invasive detection of amine-functionalized and carboxy-fu

Vertebrates capable of powered flight rely on wings, muscles that drive their flapping and sensory inputs to the brain allowing for control of the motor output. In birds, the wings are formed of arrangements of adjacent flight feathers (remiges), whereas the wings of bats consist of double-layered skin membrane stretched out between the forelimb skeleton, body and legs. Bird feathers become worn f

Assembly of the functional complexes of the mitochondrial respiratory chain requires sophisticated and efficient regulatory mechanisms. In plants, the subunit composition and assembly factors involved in the biogenesis of cytochrome c oxidase (complex IV) are substantially less defined than in mammals and yeast. In this study, we cloned maize (Zea mays) Small kernel 11 (Smk11) via map-based clonin

Ever growing environmental impact due to human activities has increased efforts globally to tackle the issues by promoting sustainable behavior. Similar efforts are also being made to handle the waste and litter problem of single-use takeaway food packaging. Sweden aims to reduce the impact of takeaway food packaging by introducing a directive to reduce consumption of single-use packaging and repl

We present an age model for the 651g€¯m deep ice core from Skytrain Ice Rise, situated inland of the Ronne Ice Shelf, Antarctica. The top 2000 years have previously been dated using age markers interpolated through annual layer counting. Below this, we align the Skytrain core to the AICC2012 age model using tie points in the ice and air phase, and we apply the Paleochrono program to obtain the bes

Background AU Self-reported: Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly adherence to the Mediterranean diet has been: modestly inversely associated with incidence of type 2 diabetes (T2D) in cohort studies. There is uncertainty about the validity and magnitude of this association due to subjective reporting of diet. The association has not been evaluated using an objectively measured

This article proposes a dual-band, frequency- and polarization-selective surface. Multiple resonant modes are introduced using the U-shaped resonator with a ground via to achieve dual-band responses and polarization selectivity. Two symmetrically grounded U-shaped resonators are coupled through electrically coupled apertures in a common ground, resulting in a passband with two transmission zeros p

Multidose injectable formulations require a preservative such as phenol to ensure sterility and protection against microbial contamination during clinical use. However, it is known that the interaction between these components and non-ionic surfactants such as polysorbate 80, also found in this type of formulations, present incompatibilities, which can lead to decreases in the efficacy of the prod

Neutralizing anti-factor VIII (FVIII) antibodies, known as FVIII inhibitors, represent a major drawback of replacement therapy in persons with congenital hemophilia A (PwHA), rendering further infusions of FVIII ineffective. FVIII inhibitors can also appear in non-hemophilic individuals causing acquired hemophilia A (AHA). The use of non-FVIII bypassing agents in cases of bleeds or surgery in inhi

The Australian lycaenid butterfly Jalmenus evagoras has iridescent wings that are sexually dimorphic, spectrally and in their degree of polarization, suggesting that these properties are likely to be important in mate recognition. We first describe the results of a field experiment showing that free-flying individuals of J. evagoras discriminate between visual stimuli that vary in polarization con