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Proconvertase furin is down regulated in postural orthostatic tachycardia syndrome

Background: Postural Orthostatic Tachycardia Syndrome (POTS) is a cardiovascular autonomic disorder characterized by orthostatic intolerance and high prevalence among young women. The etiology of POTS is uncertain, though autoimmunity and inflammation may play an important role. We aimed to identify novel inflammatory biomarkers associated with POTS. Methods and Results: In the Syncope Study of Un

Midsummer of Sex : Airing Emmanuelle on Finnish Television

Distributing sexual content has historically been more strictly regulated in Finland than in Denmark or Sweden. Airing Emmanuelle (1974), a French softcore erotic film by Jaeckin, on Finnish television in 1987 was shocking and front-page news. The article discusses the public reception of Emmanuelle in 1987 in the context of the commercialization of television in Finland.

Between Sovietism and Americanization : Ideals of femininity during and after the Cold War in Finland

During the Cold War, along with the Americanization of its popular culture, Finland was also heavily exposed to Soviet ideological influences, including in relation to notions of desirable femininity. From the late 1960s onwards, Soviet influences can be seen in Finnish public discourses on fashion and decorative femininity. Soviet ideals are also reflected in the emphasis on gender neutrality and

‘We hid porn magazines in the nearby woods’ : Memory-Work and Pornography Consumption in Finland

This article presents the key findings of a Finnish memory-work project conducted in 2012 on consumer experiences and associations related to pornography. The memory-work material points to a high degree of reflexivity in definitions of pornographic preference as well as to drastic shifts in the ubiquity of pornography from the pre-1990s ‘age of scarcity’ to the current ‘age of plenty.’ At the sam

Basic concepts and applications of functional magnetic resonance imaging for radiotherapy of prostate cancer

Recently, the interest to integrate magnetic resonance imaging (MRI) in radiotherapy for prostate cancer has increased considerably. MRI can contribute in all steps of the radiotherapy workflow from diagnosis, staging, and target definition to treatment follow-up. Of particular interest is the ability of MRI to provide a wide range of functional measures. The complexity of MRI as an imaging modali

Association Between Earliest Amyloid Uptake and Functional Connectivity in Cognitively Unimpaired Elderly

Alterations in cognitive performance have been noted in nondemented subjects with elevated accumulation of amyloid-β (Aβ) fibrils. However, it is not yet understood whether brain function is already influenced by Aβ deposition during the very earliest stages of the disease. We therefore investigated associations between [18F]Flutemetamol PET, resting-state functional connectivity, gray and white m

Antimicrobial peptides derived from the cartilage.-specific C-type Lectin Domain Family 3 Member A (CLEC3A) – potential in the prevention and treatment of septic arthritis

Objective: To investigate the antimicrobial activity of peptides derived from C-type Lectin Domain Family 3 Member A (CLEC3A), shed light on the mechanism of antimicrobial activity and assess their potential application in prevention and treatment of septic arthritis. Design: We performed immunoblot to detect CLEC3A peptides in human cartilage extracts. To investigate their antimicrobial activity,

OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis

Objective: To update and expand upon prior Osteoarthritis Research Society International (OARSI) guidelines by developing patient-focused treatment recommendations for individuals with Knee, Hip, and Polyarticular osteoarthritis (OA) that are derived from expert consensus and based on objective review of high-quality meta-analytic data. Methods: We sought evidence for 60 unique interventions. A sy

The challenge of ecological logic : Explaining distinctive organizational phenomena in corporate environmental management

INTRODUCTION The purpose of this chapter is twofold. First, it aims to provide managers and researchers with a number of concepts and perspectives which are relevant to understanding the evolution of environmental management as a corporate function. Second, in adopting and developing a critical position toward a number of current conventions or common assumptions, it aspires to add something of va

Neural and behavioural mechanisms underlying the processing of negated meanings : Words, pictures and sentences

This thesis combines a number of methodologies and measures in order to address the processing of two types of negation (with not and un) in relation to each other and to non-negated affirmative meanings. The four investigations in this thesis target the processing of these meanings at different levels, namely the word level (Study 1) and sentence level (Studies 2–4). In two artificial language le

Monochromatic computed tomography with a compact laser-driven X-ray source

A laser-driven electron-storage ring can produce nearly monochromatic, tunable X-rays in the keV energy regime by inverse Compton scattering. The small footprint, relative low cost and excellent beam quality provide the prospect for valuable preclinical use in radiography and tomography. The monochromaticity of the beam prevents beam hardening effects that are a serious problem in quantitative det