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Långvarig förskrivning av opioidläkemedel är en komplex klinisk situation där indikationen långvarig icke-malign smärta är mindre önskvärd men ändå förekommer.Problematisk användning av opioider eller utvecklande av opioidbrukssyndrom förekommer i populationen. Nedtrappning med planerat stöd och uppföljning är en medicinsk intervention som bör övervägas.Potentiella fördelar inkluderar ökad patient

This article is concerned with the estimation of aggregate relationships among a potentially large number of panel data variables in the presence of unobserved heterogeneity in the form of interactive effects, an empirically very relevant scenario that has not been considered before. One of our findings is that if the regressors load on the same set of latent factors as the dependent variable, whi

Bryt tystnaden och värna den akademiska friheten. Vi uppmanar ledare för svenska lärosäten att agera enligt sina egna etiska principer och ta ställning mot folkmordshandlingar i Gaza och angrepp på det palestinska utbildningssystemet, att försvara studenters rätt till fredliga protester och att avsluta samarbeten med universitet som är delaktiga i krigsbrott, skriver åtta forskare och akademiska l

BACKGROUND: The climacteric is the period in a woman's life that includes the transition from reproductive to non-reproductive. The woman's experience is individual, but common symptoms include irregular bleeding patterns, hot flashes, sweating, and sleep problems. Primary care should be the first instance for women seeking treatment for menopausal symptoms, and the district nurse thus plays a vit

The growing global population has increased the demand for circular sanitation solutions that enhance energy and nutrient recovery. Anaerobic digestion (AD) of blackwater (BW) offers a promising solution, but its application in full-scale UASB reactors remains unexplored. This study evaluated the performance of a full-scale UASB (50 m3) treating BW collected from a new city district (Oceanhamnen)

To address the need for sustainable wastewater treatment, we developed sp2‑carbon-rich, hierarchically porous electrodes by upcycling sewage sludge ash (SSA) and biochar (CB) using a hybrid 3D printing and microwave plasma-enhanced chemical vapor deposition (MPECVD) approach. The CB-containing electrode exhibited a 260-fold increase in BET surface area (0.15 to 40.6 m2 g−1), but the lowest electro

Foster care provides a family‐like upbringing for children who cannot stay with their biological parents for various reasons. While the practice of paying foster parents is not questioned, the level of the fee and how it is spent (or not spent) are morally charged matters. Foster parents’ motives may be questioned by the media, neighbors, or social workers, who may suspect financial gain. Although

The spatial organisation of shopping and retail has been transformed significantly since the 1980s, commonly being conceptualised as ‘retail decentralisation.’ This shift involves the displacement of retail from town centres to out-of-town establishments and, more recently, to digital platforms, creating a noticeable vacuum. Consequently, the topic of the ‘death of town centres’ has become a signi

Objective To explore teaching- and assessment-related factors that predict medical students' perceived attainment of sufficient skills to incorporate scientific evidence into patient care. Methods An anonymous questionnaire was distributed to final-semester students in six medical programs in Sweden. The students were asked to rate statements concerning the extent to which 11 national degree outco

Aims: Embryonal tumours with PLAGL1 or PLAGL2 amplification (ET, PLAGL) show substantial heterogeneity regarding their clinical characteristics and have been treated inconsistently, resulting in diverse outcomes. In this study, we aimed to evaluate the clinical behaviour of ET, PLAGL and elucidate their response pattern across the different applied treatment regimens. Methods: We conducted an in-d

Following the recent resurgence of capitalism as a key subject in historical analysis, historians have highlighted the globally interconnected making and remaking of capitalism. Commodity-centred histories in global history have shown how to write locally grounded histories of global capitalism emphasising the complex and contingent relationship between the local and the global. In these accounts,

Superconductor-semiconductor hybrid systems play a crucial role in realizing nanoscale quantum devices, including hybrid qubits, Majorana bound states, and Kitaev chains. For such hybrid devices, subgap states play a prominent role in their operation. In this paper, we study these subgap states via Coulomb and tunneling spectroscopy through a superconducting island defined in a semiconductor nanow

Objective: For better management of RA, new biomarkers are needed to predict the development of different disease courses. This study aims to identify autoantibodies against epitopes on proteins in the joints and to predict disease outcome in patients with new onset RA. Methods: Sera from new-onset RA patients from the Swedish BARFOT (Better Anti Rheumatic PharmacOTherapy) and TIRA-2 (Swedish acro

Naturvetenskap, teknik, ingenjörsvetenskap och matematik, på engelska ofta grupperade under akronymen STEM, är traditionellt mansdominerade områden. Särskilt inom ingenjörsvetenskap och teknologi är kvinnor fortfarande kraftigt underrepresenterade. Bristen på kvinnor inom STEM innebär utmaningar i att möta arbetsmarknadens behov, för produktkvalitet på grund av brist på olika perspektiv i designprScience, technology, engineering and mathematics, often grouped under the acronym STEM, are traditionally male dominated fields. Especially in engineering and technology, women continue to be heavily underrepresented. The lack of women in STEM poses challenges for meeting the labor market demands, for product quality due to a lack of diverse perspectives in the design process, and for gender equal

Importance: Cutaneous malignant neoplasms are the most common subsequent neoplasm after blood or marrow transplant (BMT), but a full assessment among survivors is lacking. Objective: To identify risk factors for subsequent cutaneous malignant neoplasms using the BMT Survivor Study (BMTSS). Design, Setting, and Participants: This retrospective cohort study included patients who underwent transplant

Green growth attempts to achieve sustainable development under continued economic growth and is currently one of the leading policy responses to mitigate climate change and prevent environmental collapse. We surveyed 3,028 academics in 101 countries on its feasibility and found strong divergence in endorsement, with 59% endorsing green growth. We identify various factors associated with beliefs ab

We show that bipartite bound entangled states make possible violations of correlation inequalities in the prepare-and-measure scenario. These inequalities are satisfied by all classical models as well as by all quantum models that do not feature entanglement. In contrast to the known Bell inequality violations from bound entangled states, we find that the violations in the prepare-and-measure scen

The Wide Field Camera 3 (WFC3) instrument on the Hubble Space Telescope has provided an abundance of exoplanet spectra over the years. These spectra have enabled analysis studies using atmospheric retrievals to constrain the properties of these objects. However, follow-up observations from the JWST have called into question some of the results from these older datasets, and highlighted the need to