Fat digestion and its role in appetite regulation and energy balance - the importance of enterostatin and tetrahydrolipstatin.
A high fat intake, together with an inability to match lipid utilization of a high-fat intake, is correlated with obesity in man. In this review enterostatin, a peptide, which specifically reduces fat intake, is described. Enterostatin is formed in the intestine by the cleavage of pancreatic procolipase, the remaining colipase serving as an obligatory cofactor for pancreatic lipase during fat dige