Objective. In cross-sectional studies, elevated osteopontin (OPN) levels have been proposed to reflect, and/or precede, progressive organ damage and disease severity in systemic lupus erythematosus (SLE). We aimed, in a cohort of patients with recent-onset SLE, to determine whether raised serum OPN levels precede damage and/or are associated with disease activity or certain disease phenotypes. Met

1988 uppmättes den allvarligaste syrebristen någonsin i Kattegatt. Syrehalten i vattnet sjönk till rekordlåga nivåer och många bottenlevande djur dog. Även i Östersjön var läget allvarligt. Även om forskarna vid denna tid hade en viss kunskap om problemets utbredning skulle det dröja ända in på 2000-talet innan man fick en heltäckande bild – en bild som delvis förvånade forskarna

Because of their symbiotic origin, many mitochondrial proteins are well conserved across eukaryotic kingdoms. It is however less obvious how specific lineages have obtained novel nuclear-encoded mitochondrial proteins. Here, we report a case of mitochondrial neofunctionalization in plants. Phylogenetic analysis of genes containing the Domain of Unknown Function 295 (DUF295) revealed that the domai

Sara Bergmark Elfgrens ungdomsskildring Norra Latin möter rösterna som vittnar inom #metoo. Ingrid Bosseldal analyserar.

Ingrid Bosseldal analyserar Ebba Witt-Brattströms bok Kulturmannen och diskuterar konsekvenser av enkla motsatspar som hon och han. Återkommande i framställningen är förutsättningarna, ett vi och ett dem som blir till i och med varandras motsatser, även om det typiskt nog mer är kvinnor än män som vill lägga till ett ”kultur” till sitt kvinnovarande. Männen, kulturmännen, är redan nedlagda i begre

Med utgångspunkt i den franske filosofen Michel Foucaults perspektiv och antologin Känslornas revolution, redigerad av Jens Ljunggren presenteras och diskuteras i den här artikeln värdet och utkomsten av att studera och analysera känsloregimer ("emotionologier").

Går det att tänka sig ett framtida samhälle där dagens professioner (läkare, advokater, lärare, präster ...) ersatts av teknologi? Vad händer om den specifika kunskap som olika professioner besitter, blir allmänt spridd? Blir vi då envar vår egen präst, lärare och läkare? Dessa frågor diskuteras med utgångspunkt i Richard och Daniel Susskinds bok Professionernas framtid.

Compartmental diffusion MRI models that account for intravoxel incoherent motion (IVIM) of blood perfusion allow for estimation of the fractional volume of the microvascular compartment. Conventional IVIM models are known to be biased by not accounting for partial volume effects caused by free water and cerebrospinal fluid (CSF), or for tissue-dependent relaxation effects. In this work, a three-co

Over the past decade, countries have strived to develop a global governance structure to halt deforestation and forest degradation, by achieving the readiness requirements for Reducing Emissions from Deforestation and forest Degradation (REDD+). Nonetheless, deforestation continues, and seemingly intact forest areas are being degraded. Furthermore, REDD+ may fail to consider the crucial ecosystem

Transformation, transition and regime shift are increasingly applied concepts in the academic literature to describe changes in society and the environment. Ecosystem services represent one framework that includes the implicit aim of supporting transformation towards a more sustainable system. Nevertheless, knowledge and systematic reviews on the use of these concepts within ecosystem services res

Background: Aerococcus urinae has lately been acknowledged as a cause of infective endocarditis (IE) especially in older males with underlying urinary tract disorders. In this population, cardiac implanted electronical devices (CIED) are not uncommon, but despite the capacity of A. urinae to form biofilm in vitro, no cases of aerococcal CIED infections have been reported to date.Case Presentation:

Thrombocytopenia is common in patients with invasive bacterial infections. Bacteria can activate platelets, but it is unclear if this affects platelet count. The aim of this study was to examine whether bacteraemia with Staphylococcus aureus, which readily activate human platelets, was more likely to be complicated by thrombocytopenia than bacteraemia with Escherichia coli or Streptococcus pneumon

With climate change, coastal areas are faced with unprecedented sea level rise and flooding, raising questions as to how societies will choose to adapt. One option is to strengthen existing sea walls to maintain current land uses; however, scientists, policy-makers and conservationists increasingly see the benefits of managed realignment, which is a nature-based coastal adaptation that involves th