Inflammatory mediators induce emergency myelopoiesis and cycling of adult hematopoietic stem cells (HSCs) through incompletely understood mechanisms. To suppress the unwanted effects of inflammation and preserve its beneficial outcomes, the mechanisms by which inflammation affects hematopoiesis need to be fully elucidated. Rather than focusing on specific inflammatory stimuli, we here investigated

Buffer management for biopharmaceutical purification processes include buffer preparation, storage of buffers and restocking the buffers when needed. This is usually performed manually by the operators for small scale operations. However, buffer management can become a bottleneck when running integrated continuous purification processes for prolonged times, even at small scale. To address this iss

Three orthogonal techniques were used to provide new insights into thermally induced aggregation of the therapeutic protein Somatropin at pH 5.8 and 7.0. The techniques were Dynamic Light Scattering (DLS), Asymmetric Flow-Field Flow-Fractionation (AF4), and the TEM-based analysis system MiniTEM™. In addition, Differential Scanning Calorimetry (DSC) was used to study the thermal unfolding and stabi

Aging negatively affects hematopoiesis, with consequences for immunity and acquired blood cell disorders. Although impairments in hematopoietic stem cell (HSC) function contribute to this, the in vivo dynamics of such changes remain obscure. Here, we integrate extensive longitudinal functional assessments of HSC-specific lineage tracing with single-cell transcriptome and epitope profiling. In cont

After the commercial emergence of 5G, the research community is already putting its focus on proposing innovative solutions to enable the upcoming 6G. One important lesson put forth by 5G research was that scaling up the conventional multiple-input-multiple-output (MIMO) technology by increasing the number of antennas could be extremely beneficial for effectively multiplexing data streams in the s

Vid Örebro universitet anordnades våren 2021 för andra gången konferensen Forskning om högre utbildning. Ett tema för konferensen var utveckling av högskolepedagogisk forskning. Högre utbildning publicerar nu tre texter på detta tema som en fördjupad diskussion. De kan läsas var för sig eller tillsammans. Den första utgörs av Sverre Wides inledningsanförande från konferensen. Efter inbjudan från rIn spring 2021, Örebro University arranged the second Swedish conference for Research in Higher Education. One of the themes for the conference was the development of higher education studies as a specific branch of this research. Our journal, Högre utbildning, now publishes three contributions linked to this theme as in-depths essays. These may be read separately or together. The first consists o

Intact forests and protected areas (PAs) are central to global biodiversity conservation and nature-based climate change mitigation. However, cropland encroachment threatens the ecological integrity and resilience of their functioning. Using satellite observations, we find that a large proportion of croplands in the remaining forests globally have been gained during 2003–2019, especially for high-

Sea urchins can detect light and move in relation to luminous stimuli despite lacking eyes. They presumably detect light through photoreceptor cells distributed on their body surface. However, there is currently no mechanistic explanation of how these animals can process light to detect visual stimuli and produce oriented movement. Here, we present a model of decentralized vision in echinoderms th

Remediation of soil contaminated with cadmium (Cd) and lead (Pb) is critical for tobacco production. Silicon (Si) fertilizer can relieve heavy metal stress and promote plant growth, however, it remains unknown whether fertilization with Si can mitigate the effects of Cd and Pb on tobacco growth and alter microbial community composition in polluted soils. Here we assessed the effect of two organic

OBJECTIVE: The aim of this study was to explore the association between quadriceps strength and synovitis in knee osteoarthritis (KOA). METHODS: This study was derived from the Osteoarthritis Initiative (OAI), which recruited adults from the OAI cohort with or at risk of KOA. Knees with complete records of isometric quadriceps strength and effusion-synovitis and Hoffa-synovitis assessments were in

Mating system shifts from outcrossing to selfing are frequent in plant evolution. Relative to outcrossing, selfing is associated with reduced parental conflict over seed provisioning, which may result in postzygotic, asymmetric, reproductive isolation in crosses between populations of different mating systems. To test the hypothesis that post-pollination reproductive isolation between populations

The evolution of separate sexes from hermaphroditism is thought to have occurred independently many times, and may be linked to the evolution of sex chromosomes. Even though we have a good understanding of the theoretical steps in the evolution of sex chromosomes from a hermaphrodite ancestor, the initial stages are still hard to study in animals because many well-studied animal sex chromosome sys

OBJECTIVE: To assess the frequency of comorbidities and metabolic risk factors at and prior to giant cell arteritis (GCA) diagnosis. METHODS: This is a retrospective case control study of patients with incident GCA between January 1, 2000, and December 31, 2019, in Olmsted County, Minnesota. Two age- and sex-matched controls were identified, and each assigned an index date corresponding to an inci

The idea that sex differences in selection drive the evolution of suppressed recombination between sex chromosomes is well developed in population genetics. Yet, despite a now classic body of theory, empirical evidence that sexually antagonistic selection drives the evolution of recombination arrest remains equivocal and alternative hypotheses underdeveloped. Here, we investigate whether the lengt

The strong interaction is responsible for nearly all observable baryonic matter in the Universe. Quantum Chromodynamics, which describes interactions between quarks and gluons, however, cannot be solved analytically in the non-perturbative regime, involving low momentum transfers. In this regime, interesting phenomena occur, such as the formation of colour-neutral hadrons from constituent quarks a

After World War II and prior to the financial deregulation of the 1980s,monetary policy in Sweden as well as in other western Europeancountries rested chiefly on a system of far-reaching non-market-orientedcontrols of credit flows and interest rates. How was monetary policyconducted in such an environment of financial repression, where thecentral bank was unable to rely on traditional monetary pol

Objectives Nocturnal hypoxia in obstructive sleep apnoea (OSA) is a potential risk factor for cancer. We aimed to investigate the association between OSA measures and cancer prevalence in a large national patient cohort. Design Cross-sectional study. Settings 44 sleep centres in Sweden. Participants 62 811 patients from the Swedish registry for positive airway pressure (PAP) treatment in OSA, link