A transgenic mouse model of Huntington's disease (R6/1 and R6/2 lines) expressing exon 1 of the HD gene with 115-150 CAG repeats resisted striatal damage following injection of quinolinic acid and other neurotoxins. We examined whether excitotoxin resistance characterizes mice with mutant huntingtin transgenes. In a new transgenic mouse with 3 kb of mutant human huntingtin cDNA with 18, 46, or 100

This article outlines a general theory of meaning, The Semiotic Hierarchy, which distinguishes between four major levels in the organization of meaning: life, consciousness, sign function and language, where each of these, in this order, both rests on the previous level, and makes possible the attainment of the next. This is shown to be one possible instantiation of the Cognitive Semiotics program

Recent research suggests that self-employment among immigrants is due to a combination of multiple situational, cultural and institutional factors, all acting together. Using multilevel regression and unique data on the entire population of Sweden for the year 2007, this study attempts to quantify the relative importance for the self-employed of embeddedness in ethnic contexts (country of birth) a

The time dependent Maxwell system is supplemented with the constitutive relations of linear bianisotropc media and is treated as a neutral integro-differential equation in a Hilbert space. By using the theory of abstract Volterra equations and strongly continuous semigroups we obtain general well-posedness results for the corresponding mathematical problem.

Three young men were trapped in a car at the bottom of a canal at two meters depth, after losing control of their vehicle. They were brought up by rescue divers and found in cardiac arrest. One of three patients had return of spontaneous circulation (ROSC), at 47 min after the accident. This sole survivor had the longest submersion time of the three and he received continued mechanical chest compr

The present study describes the anthropometrics of the Swedish workforce, aged 18-65, and compares the measurements with data collected four decades earlier. This anthropometric information is based on measurements of a total of 367 subjects, 105 males and 262 females. Of the 367 subjects, 268 responded to advertisements (Study A) and 99 were randomly selected from a community register (Study B).

This thesis focuses on the development and testing of electrocardiographic (ECG) methods to diagnose and characterize myocardial ischemia, infarction and fibrosis (scar). The goal is to provide improved decision support to physicians regarding the optimal selection of patients for two costly, invasive therapies – percutaneous coronary intervention (PCI) for patients with acute myocardial infarctio

Objectives The study investigated the noise exposure in a group of Danish school teachers. The aims were to investigate if noise posed a risk of impairment of hearing and to study the association between classroom acoustical conditions, noise exposure, vocal symptoms, and cognitive fatigue. Methods Background noise levels, vocal load and speaking time were measured on 35 teachers during actual cla

A single antenna based virtual antenna array at the receiver can be used to find direction of different incoming radio signals impinging at the receiver. In this paper, we investigate the performance of random 3D virtual antenna arrays for DoA estimation. We have computed a Cramer-Rao Lower Bound (CRLB) for DoA estimation if the true antenna positions are not known, but these are estimated with an

Background: Assessing left ventricular (LV) dysfunction by echocardiography in ICU patients is common. The aim of this study was to investigate mitral annular plane systolic excursion (MAPSE) in critically ill patients with shock and its relation to LV systolic and diastolic function, myocardial injury and to outcome. Methods: In a prospective, observational, cohort study we enrolled 50 patients w

The use of performance enhancing drugs, especially anabolic androgenic steroids (AAS) has emerged as a social problem outside competitive sports, linked to substance abuse and crime. The purpose of this article is to analyze the use of doping and attitudes to doping outside the competitive sports context in relation to age, gender, ethnicity, so¬cio-economic status, and branch of sport. The articl

Protein glycosylation has significant effects on the structure and function of proteins. The efficient separation and enrichment of glycoproteins from complex biological samples is one key aspect and represents a major bottleneck of glycoproteome research. In this paper, we have explored pH multimodal hydrophobic interaction chromatography to separate glycosylated from non-glycosylated forms of pr

Precise measurements of the lifetimes of the first excited 2(+) states in the stable even-A Sn isotopes Sn112-124 have been performed using the Doppler shift attenuation technique. For the isotopes Sn-112, Sn-114 and Sn-116 the E2 transition strengths deduced from the measured lifetimes are in disagreement with the previously reported values and indicate a shallow minimum at N = 66. The observed d

We propose and demonstrate a new approach for the simulation of woody ecosystem stand dynamics, demography, and disturbance-mediated heterogeneity suitable for continental to global applications and designed for coupling to the terrestrial ecosystem component of any earth system model. The approach is encoded in a model called Populations-Order-Physiology (POP). We demonstrate the behavior and per

Glucocorticoids play a role in the origin of the features of the metabolic diseases. Alpha-ketoglutarate (AKG) is defined as glutamine homologue and derivative, conditionally an essential amino acid. In the liver, glutamine serves as a precursor for ureagenesis, gluconeogenesis and acute phase protein synthesis The aim of the study was to determine the effect of AKG administered to piglets prenata

OBJECTIVE-To report the incidence of sight-threatening vascular lesions in type 2 diabetic subjects without retinopathy after adopting a 3-year interval screening program. RESEARCH DESIGN AND METHODS-In all, 1,691 type 2 diabetic subjects with no detectable retinopathy in two 50 degrees red-free fundus photographs were scheduled for follow-up with photography 3 years later. Age at diabetes diagnos

OBJECTIVE-Metformin produced weight loss and delayed or prevented diabetes in the Diabetes Prevention Program (DPP). We examined its long-term safety and tolerability along with weight loss, and change in waist circumference during the DPP and its long-term follow-up. RESEARCH DESIGN AND METHODS-The randomized double-blind clinical trial of metformin or placebo followed by a 7-8-year open-label ex

Some key political challenges today, e.g. climate change, are future oriented. The intergenerational setting differs in some notable ways from the intragenerational one, creating obstacles to theorizing about intergenerational justice. One concern is that as the circumstances of justice do not pertain intergenerationally, intergenerational justice is not meaningful. In this paper, I scrutinize thi

BACKGROUND/OBJECTIVES: Prospective cohort studies have indicated that serum vitamin D levels are inversely related to risk of type 2 diabetes. However, such studies cannot determine the source of vitamin D. Therefore, we examined the association of dietary vitamin D intake with incident type 2 diabetes within the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study in