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Background: Metabolic syndrome (MetS) is associated with high cardiovascular morbidity and mortality, and endothelial dysfunction is an early pathogenetic event in the MetS. Lifestyle changes and pharmacological intervention might partly restore endothelial function in MetS. Whereas an optimal non-invasive test for endothelial dysfunction is still being sought, the aim of this study was to assess

The recent experimental measurement of the muon g−2 at Fermilab National Laboratory, at a 4.2σ tension with the Standard Model prediction, highlights the need for further improvements on the theoretical uncertainties associated to the hadronic sector. In the framework of the operator product expansion in the presence of a background feld, the short-distance behaviour of the hadronic light-by-light

The negative impact of maritime traffic in terms of shore erosion in sheltered coastal fairways can be mitigated by sustainable fairway management. Mitigation measures include regulating the ship traffic in terms of speed, routes, or size of ships, but can also involve erosion protection along a fairway. For effective shoreline management of a fairway, it is essential to predict ship waves, to ide

New conodont and stable isotope data are presented from the classical Baizitian section in the Yanbian County of Sichuan Province, South China. The Telychian to Sheinwoodian strata were sampled and studied for carbon isotope stratigraphy and conodont biostratigraphy. The paired δ13Ccarb and δ13Corg data reveal a pronounced positive excursion, the Manitowoc carbon isotope excursion (Manitowoc CIE,

An exhaustive evaluation of water resources is a prerequisite for evidence-informed planning and implementing sustainable management strategies. However, the lack of sufficient information on water supply and consumption, alongside the technical limitations on comprehensive accounting for inter-relations and interactions between the subsystems, has resulted in decisions with often long-lasting out

Purpose: Brain tumours constitute 25% of childhood neoplasms, and half of them are in the posterior fossa. Surgery is a fundamental component of therapy, because gross total resection is associated with a higher progression-free survival. Patients with residual tumour, progression of residual tumour or disease recurrence commonly require secondary surgery. We prospectively investigated the risk of

The rhizosphere priming effect (RPE) is increasingly being considered to be an important regulator of soil organic matter (SOM) decomposition and nutrient turnover, with potential importance for the global CO2 budget. As a result, studies on the RPE have rapidly increased in number over the last few years. Most of these experiments have been performed using unplanted soil as the control, which cou

Purpose: Chronic inflammation is thought to initiate or promote differentiated thyroid cancer (DTC) and previous studies have shown that diet can modulate this inflammatory process. We aimed to evaluate the association of several dietary scores reflecting the inflammatory potential of the diet with DTC risk. Methods: Within the EPIC cohort, 450,063 participants were followed during a mean period o

Climate change is pushing species ranges and abundances towards the poles and mountain tops. Although many studies have documented local altitudinal shifts, knowledge of general patterns at a large spatial scale, such as a whole mountain range, is scarce. From a conservation perspective, studying altitudinal shifts in wildlife is relevant because mountain regions often represent biodiversity hotsp

This paper develops a model based on the concept of Positive Mathematical Programming (PMP) that is useful for ex-ante analyses of how policy measures affect commercial fisheries. PMP models are frequently used in agriculture, but rarely for analyzing fisheries. Fisheries often face a large set of constraints such as effort regulations and catch quotas of which some might be binding and others not

IntroductionThe interest in Para athletes’ health continues to increase. Still, there are few studies that have evaluated health parameters beyond injury and illness in this athlete population.ObjectiveTo assess: i) the weekly proportion of elite Para athletes reporting anxiety/depression, low sleep levels (≤7 hours) and pain over 52 weeks and; ii) and to explore whether these health parameters ar

There is substantial evidence that women tend to support different policies and political candidates than men. Many studies also document gender differences in a variety of important preference dimensions, such as risk-taking, competition and pro-sociality. However, the degree to which differential voting by men and women is related to these gaps in more basic preferences requires an improved unde

Traditional fire alarms emit a high-frequency sound to alert the occupants of an imminent threat, which may be less appropriate for people who are deaf or hard of hearing. To address this issue, the scientific literature concerning alternative alarm technologies has been reviewed to evaluate their effectiveness in awakening people who are deaf or hard of hearing. The results show that low-frequenc

This study aims to quantify and develop a deeper understanding of the parameters that underpin the development of a new, predictive, microscopic model of pedestrian movement with the potential to accurately reflect the complexity of flow dynamics now and into the future. It presents the results and analyses of two single file experiments designed to quantify the physical space taken up by the exte

Pollinators are critical for food security; however, their contribution to the pollination of locally important crops is still unclear, especially for non-bee pollinators. We reviewed the diversity, conservation status, and role of bee and non-bee pollinators in 83 different crops described either as important for the global food market or of local importance. Bees are the most commonly recorded c

AXL, a member of the TAM family, is a promising therapeutic target due to its elevated expression in advanced hepatocellular carcinoma (HCC), particularly in association with acquired drug resistance. Previously, RNA interference was used to study its role in cancer, and several phenotypic changes, including attenuated cell proliferation and decreased migration and invasion, have been reported. Th

Hepatocyte dedifferentiation is a major source of hepatocellular carcinoma (HCC), but its mechanisms are unknown. We explored the p73 expression in HCC tumors and studied the effects of transcriptionally active p73β (TAp73β) in HCC cells. Expression profiles of p73 and patient clinical data were collected from the Genomic Data Commons (GDC) data portal and the TSVdb database, respectively. Global