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Genetic variation in the PTH pathway and bone phenotypes in elderly women: Evaluation of PTH, PTHLH, PTHR1 and PTHR2 genes.

INTRODUCTION: Parathyroid hormone (PTH) is a key regulator of calcium metabolism. Parathyroid hormone-like hormone (PTHrP) contributes to skeletal development through regulation of chondrocyte proliferation and differentiation during early bone growth. Both PTH and PTHrP act through the same receptor (PTHR1). A second receptor, PTHR2, has been identified although its function is comparatively unkn

Multiple implants do not aggravate the tissue reaction in rat brain.

Chronically implanted microelectrodes are an invaluable tool for neuroscientific research, allowing long term recordings in awake and behaving animals. It is known that all such electrodes will evoke a tissue reaction affected by its' size, shape, surface structure, fixation mode and implantation method. However, the possible correlation between tissue reactions and the number of implanted electro

Optical spectroscopy of turbid media: time-domain measurements and accelerated Monte Carlo modelling

Popular Abstract in Swedish Denna avhandling handlar om optisk spektroskopi, d.v.s. att med hjälp av ljus best ̈mma fysiska och kemiska egenskaper hos ett prov. När ljus interagerar med atomer och molekyler absorberas endast ljus av vissa våglängder (färger). Exakt vilka färger som absorberas är unikt för varje sorts atom eller molekyl och utgör alltså ett sorts ”fingeravtryck”. Genom att noggranOptical spectroscopy is a versatile and powerful tool to probe translucent materials. In this work, the focus is on characterization of strongly scattering (turbid) materials by means of time-of-flight spectroscopy (TOFS). Instrumentation and modelling aspects of TOFS were investigated and improved, enabling significantly more accurate spectroscopic measurements. It was shown that the commonly us

Environmental management in Swedish manufacturing industries

This study illustrates how Swedish manufacturing industries are managing issues that pertain to how their business activities and operations impact the external environment. This is a follow-up study of Arnfalk and Thidell ’s study Environmental Management in Swedish Manufacturing Industries? Facts or Fiction?(1991). The 1998 study was based on telephone interviews with company representatives fro

Spectral Shape of UWB Signals-Influence of Modulation Format, Multiple Access Scheme and Pulse Shape

This paper studies how to design the spectrum of a UWB signal in accordance with the FCC regulations and IEEE 802.15.3a recommendations. We show that the "conventional" UWB system with pulse-position modulation and time-hopping multiple access gives rise to spectral lines that violate the regulations. The impact of different modulation and multiple access schemes on the spectrum shaping is derived

Robotic implementation of a microchip-based protein clean-up and enrichment system for MALDI-TOF MS readout

A capillary filling microfluidic proteomic sample processing system has been realized in an automated set-up. Chip-integrated solid-phase extraction is performed in a 96-array format followed by sequential capillary action elution into a piezoelectric microdispenser and subsequent transfer to MALDI targets. Samples are eluted and deposited in volumes of 200–300 nl. The robotic system offers calibr