Woolly mammoths had a set of adaptations that enabled them to thrive in the Arctic environment. Many mammoth-specific single nucleotide polymorphisms (SNPs) responsible for unique mammoth traits have been previously identified from ancient genomes. However, a multitude of other genetic variants likely contributed to woolly mammoth evolution. In this study, we sequenced two woolly mammoth genomes a

Aim: This study analyzed time trends in the use of coronary procedures, guideline-based drugs, and 1-year all-cause and presumed cardiovascular mortality (CV) following acute coronary syndrome (ACS) in patients with and without bipolar disorder (BD). Method: Using Danish registries 497 patients with ACS and BD in the period 1996–2016 were matched 1:2 on age, sex and year of ACS to patients without

Increasing evidence shows that climate change and other sustainability challenges are, in fact, internal relationship crises. The author points to the potential of our minds, mindfulness, and compassion to stem the climate crisis through their potential to foster fundamental aspects of connection, including our human relationship with nature.

This report presents the assessment of a six-week online course offered by BeChange, which was given from April to June in 2022. Through a total of five online sessions, an interactive learning platform, diverse practices and individual coaching, the course aimed to support participants in reducing their CO2 emissions, increase their climate engagement, and at the same time enhance their wellbeing

Background Implementation in healthcare is often slow and poorly reported. Results include suboptimal outcomes and ad-verse consequences for patients. However, promising tools to remedy implementation speed and reporting already exist – such as the evidence-based, fast-track implementation model (Fast-IM) and the comprehensive RE-AIM (reach, effectiveness, adoption, implementation, and maintenance

Objective To determine if patients with systemic lupus erythematosus (SLE), a disease characterised by elevated type I interferons reminiscent of anti-viral immunity, have expression of human endogenous retrovirus K (HERV-K) proviruses capable of producing envelope (Env) protein, as well as associated autoantibodies against the Env protein. Methods ELISAs were conducted with recombinant Env protei

As academic librarians at a medical faculty, we promote open science practices by educating researchers about the implications of open license conditions. Researchers are sometimes faced with a choice of path in the process of publishing open access, when the publisher offers a choice of different Creative Commons licenses. They are often not aware of what the terms of the licenses mean in practic

The rise of animals represents a major but enigmatic event in the evolutionary history of life. In recent years, numerous studies have aimed at understanding the genetic basis of this transition. However, genome comparisons of diverse animal and protist lineages suggest that the appearance of gene families that were previously considered animal specific indeed preceded animals. Animals’ unicellula

Solid-state properties of dried protein formulations are important for stability and functionality of the product. This study investigates how different drying technologies (freeze-drying with and without annealing, spray drying and spray-freeze drying) affect the structure and solid-state properties of a set of matrix formulations composed of trehalose (glass former) and mannitol (scaffolding age

The extraction of the W-boson mass, a fundamental parameter of the Standard Model, from hadron-hadron collision requires precise theory predictions. In this regard, angular coefficients are crucial to model the dynamics of W-boson production. In this work, we provide, for the first time, angular coefficients at NNLO QCD + NLO EW accuracy for finite transverse momentum W-boson at the LHC. The corre

We use principal component analysis to study the hydrodynamic attractor in Yang-Mills kinetic theory undergoing the Bjorken expansion with color glass condensate initial conditions. The late-time hydrodynamic attractor is characterized by a single principal component determining the overall energy scale. How it is reached is governed by the disappearance of single subleading principal component ch

Researchers have proposed hardware, software, and algorithmic optimizations to improve the computational performance of deep learning. While some of these optimizations perform the same operations faster (e.g., increasing GPU clock speed), many others modify the semantics of the training procedure (e.g., reduced precision), and can impact the final model's accuracy on unseen data. Due to a lack of

Plastic extension of Minuet K.73 by Domenico Scarlatti. Video (2:17 min)

We propose a generalisation of a behaviour tree and motiongenerator based robot arm policy representation for learning and solving tasks such as contact-rich tasks like peg insertion or pushing an object. We use planning to generate skill sequences needed to execute these tasks and rely on reinforcement learning to obtain parameters of the policy. We assume gaussian processes as a suitable method

The presence of conventional dendritic cells type 1 (cDC1) in the tumor correlates with positive treatment outcome. The ability to cross-present neoantigens and prime protective CD8+ T-cell responses, makes cDC1s central for tumor immunity. However, in tumors cDC1 are rare and often functionally impaired. Our group reported that overexpression of the transcription factors PU.1, IRF8 and BATF3 (PIB