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Planet Formation Imager (PFI) : Science vision and key requirements

The Planet Formation Imager (PFI) project aims to provide a strong scientific vision for ground-based optical astronomy beyond the upcoming generation of Extremely Large Telescopes. We make the case that a breakthrough in angular resolution imaging capabilities is required in order to unravel the processes involved in planet formation. PFI will be optimised to provide a complete census of the prot

HIV-1-neutralizing IgA detected in genital secretions of highly HIV-1-exposed seronegative women on oral preexposure prophylaxis

Although nonhuman primate studies have shown that simian immunodeficiency virus/simian-human immunodeficiency virus (SIV/SHIV) exposure during preexposure prophylaxis (PrEP) with oral tenofovir can induce SIV immunity without productive infection, this has not been documented in humans. We evaluated cervicovaginal IgA in Partners PrEP Study participants using a subtype C primary isolate and found

An index of floodplain surface complexity

Floodplain surface topography is an important component of floodplain ecosystems. It is the primary physical template upon which ecosystem processes are acted out, and complexity in this template can contribute to the high biodiversity and productivity of floodplain ecosystems. There has been a limited appreciation of floodplain surface complexity because of the traditional focus on temporal varia

Measuring floodplain spatial patterns using continuous surface metrics at multiple scales

Interactions between fluvial processes and floodplain ecosystems occur upon a floodplain surface that is often physically complex. Spatial patterns in floodplain topography have only recently been quantified over multiple scales, and discrepancies exist in how floodplain surfaces are perceived to be spatially organised. We measured spatial patterns in floodplain topography for pool 9 of the Upper

Floodplain complexity and surface metrics : Influences of scale and geomorphology

Many studies of fluvial geomorphology and landscape ecology examine a single river or landscape, thus lack generality, making it difficult to develop a general understanding of the linkages between landscape patterns and larger-scale driving variables. We examined the spatial complexity of eight floodplain surfaces in widely different geographic settings and determined how patterns measured at dif

The ecohydrology of stream networks

Stream ordering approaches to the study of entire stream networks are relatively simple and provide only crude estimations of the physical makeup of river ecosystems. These fail to acknowledge the importance of the hierarchical organisation of rivers and consequently use very crude variables when characterising stream networks. We provide an alternative typology for characterising the physical str

Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism

SEE GANDHI AND PLUN-FAVREAU DOI101093/AWW320 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: It has been postulated that heterozygous mutations in recessive Parkinson's genes may increase the risk of developing the disease. In particular, the PTEN-induced putative kinase 1 (PINK1) p.G411S (c.1231G>A, rs45478900) mutation has been reported in families with dominant inheritance patterns of Parkinson's

A typology of fisheries management tools : Using experience to catalyse greater success

Fisheries provide nutrition and livelihoods for coastal populations, but many fisheries are fully or over-exploited and we lack an approach for analysing which factors affect management tool performance. We conducted a literature review of 390 studies to assess how fisheries characteristics affected management tool performance across both small-scale and large-scale fisheries. We defined success a

Measuring spatial patterns in floodplains : A step towards understanding the complexity of floodplain ecosystems

This chapter focuses on measuring spatial pattern in floodplains and reviews 108 publications from 1934-2013 to determine trends, dominant paradigms, and approaches to measuring spatial pattern in floodplains. The development of new technologies, especially those associated with remotely sensed data capture, increases the ability to quantitatively measure the spatial complexity of floodplain surfa

The variation of productivity and its allocation along a tropical elevation gradient : A whole carbon budget perspective

Summary: Why do forest productivity and biomass decline with elevation? To address this question, research to date generally has focused on correlative approaches describing changes in woody growth and biomass with elevation. We present a novel, mechanistic approach to this question by quantifying the autotrophic carbon budget in 16 forest plots along a 3300 m elevation transect in Peru. Low growt

Impacts of global change on species distributions : Obstacles and solutions to integrate climate and land use

Aim The impact of multiple stressors on biodiversity is one of the most pressing questions in ecology and biodiversity conservation. Here we critically assess how often and efficiently two main drivers of global change have been simultaneously integrated into research, with the aim of providing practical solutions for better integration in the future. We focus on the integration of climate change

Systematic literature review on effectiveness of self-management support interventions in patients with chronic conditions and low socio-economic status

Aim: To assess the quality of evidence and determine the effect of patient-related and economic outcomes of self-management support interventions in chronically ill patients with a low socio-economic status. Background: Integrated evidence on self-management support interventions in chronically ill people with low socio-economic status is lacking. Design: Systematic literature review. Data sources

Avian migration and the distribution of malaria parasites in New World passerine birds

Aim: Migrating birds transport their parasites, often over long distances, but little is known about the transfer of these parasites to resident hosts in either the wintering or breeding ranges of the migratory host populations. We investigated the haemosporidian parasite faunas of migratory and resident birds to determine connections among distant parasite faunas, plausibly brought about by migra