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Förändringar i hjärnan vid avsaknad av CYP27A1 CYP27A1 är en gen vars färdiga protein är involverat i nedbrytning av kolesterol och gallsyrasyntes. Avsaknad av CYP27A1 eller produktion av en dysfunktionell variant av proteinet i människor resulterar i sjukdomen Cerebrotendinös xantomatos (CTX). CTX är en sjukdom som karaktäriseras av grumling av ögats lins, lipidinlagringar i form av knutor i senCYP27A1 is an important enzyme in cholesterol catabolism and bile acid biosynthesis. Deficiency of this enzyme in human leads to the disease Cerebrotendinous xanthomatosis (CTX), which is a recessively inherited lipid storage disorder characterized by symptoms such as cataracts, tendon xanthomas and progressive neurological syndrome. The underlying cause for the neurological symptoms is not well u

So far, broad-based assessments of health outcomes are scarce for Ethiopian women. Little is known about differences in overall health performance between regions. On that account, the present research scrutinizes a diversity of seven health indicators for women of their reproductive age. By this means, a deeper understanding of underlying mechanisms in female health performance over time and spac

Varje dag publiceras stora mängder nyheter som både informerar och påverkar människor. I takt med framsteg inom maskininlärning samt att datorkraft blivit mer tillgängligt har nya tillvägagångsätt för att automatisk analysera text tillkommit. I kombination med att mer och mer alternativa datakällor används för att utföra aktieanalyser har detta resulterat i ett nytt forskningområde: automatisk texThis master thesis explores if topic modelling and sentiment analysis on Swedish financial newspaper data can be used to predict the direction of the Swedish stock market. A pipeline was set up where full length articles as well as article summaries were fed into a topic model and a sentiment analysis model. Several methods for combining the outputs of these models were explored in order to create

This thesis work is an academic study investigating how to transform and re-purpose the abandoned hydroelectric powerplant, Hästbergadammen. The powerplant has been abandoned since the dam collapsed in 2010, and the case of rebuilding it has been in the Land and Environment Court since 2016. The thesis proposes a new purpose for the site. It suggests giving back a public monumental place where t

Thesis Purpose: The purpose of this study is to explore and develop an understanding of the rather unexplored phenomenon of using flagship stores in the FMCG industry. We want to explore what an FMCG flagship store is to understand why it is used in the context of strategic brand management. Moreover, we want to develop an understanding of how the brand experience might influence the consumer-bran

Using direct cell reprogramming to induce functional plasmacytoid dendritic cells from fibroblasts Direct cell reprogramming is a technique used to generate differentiated cells of one lineage from somatic cells of another. This concept has been used to explore the diversity and function of numerous cell types. Plasmacytoid dendritic cells (pDCs) are a subset of dendritic cells specialized at pro

With this research we aim to understand the dynamics of consumers' use of cancel culture as a resource for their identity construction online. Theories included were surrounding framing, morality, consumers as moral protagonists, purity and dirt as well as distaste and symbolic violence. These theories were selected to aid with the analysis of the empirical material and to add new insight to t

Despite being their closest evolutionary relatives, chimpanzees have a substantially different brain compared to humans: Homo sapiens display larger and more complex forebrains, although the protein-coding genes between the two species are basically unchanged. Therefore, differences in the transcriptome and in regulatory networks must be further investigated to better understand the dissimilaritie

The 83 million year old family tree of burnet moths To classify the living world around them, early on humans started naming plants and animals in order to distinguish food from non-food, predator from prey, etc. In 1800s a practice of a more formal way of classifying the living world was started, in which using Latin names made the classification universal. The unique appearances were used to di

Human-wildlife conflicts threaten the existence of many species worldwide. Large carnivores are often involved in such conflicts due to their diets and expansive home ranges. In Finland, wolf (Canis lupus) is one of such conflict-prone species. The wolf conflict is a multifaceted issue stemming for instance from fears, damages to domestic animals, competition for game and opposition of EU wildlife

The purpose of this paper is to investigate what motivates the recidivism discrepancy between populations with: severe psychiatric disorder and non-severe psychiatric disorder. The aim is to introduce an argument for biopsychosocial influences as underlying an individual’s propensity to act, using Luhmannian systems theory. By making use of current research on social and neurological risk factors,

I denna magisteruppsats undersöks hur dialekten i romanen Machandel av Regina Scheer kan översättas till svenska på ett källtexttroget sätt. Inom ramen för magisterarbetet har utdrag ur romanen översatts, och i uppsatsen analyseras denna översättning. Dialektens centrala roll i verket presenteras i en källtextanalys, följd av ett resonerande kapitel om utgångspunkterna för översättningen. Riktlinj

The overall purpose of the thesis is to gather deeper insights into the redesign of management control systems (MCSs) following a shift in value emphasis in family-owned firms by exploring the different dynamics of the family business system (FBS). Furthermore, the research has aimed to find an answer to how a shift from family management to external management influences the value emphasis, and h

Barn som bevittnat våld i nära relationer är en utsatt grupp vars behov ofta förbises(Socialstyrelsen 2019). Såväl svensk som internationell forskning på området visar att denna form av utsatthet får allvarliga konsekvenser på både lång och kort sikt. Samtidigt indikerar andra studier på kunskapsluckor och brister i arbetet med barn som bevittnat våld vilket resulterar i att dessa barn inte får de

Emerging infectious diseases (EID) continue to threaten the persistence of wildlife populations. The standing genetic variation of a population can affect its ability to adapt to environmental changes like EID. Levels of variation at immune genes, such as toll-like receptor genes (TLR) of the innate immune system, are particularly relevant. The current study explores the role of demographic histor

Fractal curves are self similar objects, most of which have the property of being nowhere differentiable. The foundations of fractal curves are in the study of continuous functions with no points of differentiability. In this thesis, the continuity and nowhere differentiability of the Weierstrass function will be proved by using an auxiliary function and mostly elementary tools from Fourier analys

En viktig del av finansmarknaden är kreditmarknaden, där företag, banker och investerare köper och säljer olika former av skuldbrev. Ett ofta använt verktyg på kreditmarknaden är den så kallade avkastningskurvan. Avkastningskurvan beskriver räntan på en samling liknande obligationer som en funktion av löptiden. Den är viktig för att prissätta instrumenten som handlas på kreditmarkaden, men kan äveThe yield curve of a collection of debt contracts describes the yield of the debt contract as a function of the length-to-maturity of the contract. It turns out that these yield curves provide useful insight about the economy as a whole and can, for example, be used to predict short-term economic downturns. Therefore, it is of utmost importance that financial analysts and decision-makers are able

Berlin Dialect in Swedish? : How Berlin Dialect is Represented in the Swedish Translation of Berlin Alexanderplatz Alfred Döblin’s modern novel Berlin Alexanderplatz, first published in 1929, is strongly characterized by the Berlin dialect and colloquial speech. The first complete Swedish translation of this renown work was conducted by Ulrika Wallenström in 1978. This thesis investigates to what

This thesis analyses the relationship between sustainability transformations and grassroots movements in Monteverde, Costa Rica. The focus is toward understanding the influence of community-based initiatives on transformations that have sustainability as a goal, due to their potential for shaping society and addressing challenges such as climate change. The study also examines the emergence and de