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Background: Molecular signatures in prostate cancer (PCa) tissue can provide useful prognostic information to improve the understanding of a patient's risk of harbouring aggressive disease. Objective: To develop and validate a gene signature that adds independent prognostic information to clinical parameters for better treatment decisions and patient management. Design, setting, and participants:

Remote sensing is an effective means for lake water level monitoring on the Tibetan Plateau (TP). The purpose of this study is to estimate water levels of lakes on the TP using the Global Ecosystem Dynamics Investigation (GEDI) and Cloud and Land Elevation Satellite-2 (ICESat-2), evaluate the performance of ICESat-2 and GEDI in estimating water levels, and analyze the differences of water level ob

Background: Patients with muscle-invasive bladder cancer (MIBC) constitute a heterogenous group in terms of patient and tumour characteristics (‘case-mix’) and prognosis. The aim of the current study was to investigate whether differences in survival could be used to separate MIBC patients into separate classes using a recently developed latent class regression method for survival analysis with co

The present exploratory study is aimed at the modelling of the chemiluminescence signature of premixed laminar NH3+H2+air flames. The detailed kinetic mechanism of the author was extended by reactions describing the formation and consumption of excited NO2*, NO(A), NH*, and NH2* mostly relying on previous analyses of chemiluminescence processes from the literature. The lowest-lying excited state o

INTRODUCTION: Monocytes are key effector cells in inflammatory processes. We and others have previously shown that synovial monocytes in childhood-onset arthritis are activated. However, very little is known about how they contribute to disease and attain their pathological features. Therefore, we set out to investigate the functional alterations of synovial monocytes in childhood-onset arthritis,

Background Human trafficking is considered a hidden global crime with unsubstantiated numbers. Despite the challenges in counting or measuring this crime, reports revealed the presence of around 40.3 million victims worldwide. Human trafficking results in severe detrimental impacts on both mental and physical health. Given the sensitivity and negative consequences of human trafficking on the globa

En bok om "det modernas sociala innebörd", om trendskiften och nya attityder gällande allt från förnamn och badrumsinredningar till mat, pedagogik och terapi.

Selection leading to adaptation to interactions may generate rapid evolutionary feedbacks and drive diversification of species interactions. The challenge is to understand how the many traits of interacting species combine to shape local adaptation in ways directly or indirectly resulting in diversification. We used the well-studied interactions between Lithophragma plants (Saxifragaceae) and Grey

PURPOSE: While patients with intermediate-risk (IR) Wilms tumors now have an overall survival (OS) rate of almost 90%, those affected by high-stage tumors with diffuse anaplasia have an OS of only around 50%. We here identify key events in the pathogenesis of diffuse anaplasia by mapping cancer cell evolution over anatomic space in Wilms tumors.EXPERIMENTAL DESIGN: We spatially mapped subclonal la