The development of oncolytic viruses has recently made great progress towards being available to cancer patients. With the breakthrough into clinics, it is crucial to analyze the existing clinical experience and use it as a basis for treatment improvements. Here we report clinical data from 290 patients treated with oncolytic adenovirus. Using clinical variables and treatment characteristics, we c

Background The outcome of axillary ultrasound (AUS) with fine-needle aspiration biopsy (FNAB) in the diagnostic work-up of primary breast cancer has an impact on therapy decisions. We hypothesize that the accuracy of AUS is modified by nodal metastatic burden and clinico-pathological characteristics. Material and methods The performance of AUS and AUS-guided FNAB for predicting nodal metastases wa

OBJECTIVE: This nationwide study aimed to determine whether venous thromboembolism (VTE) shares familial susceptibility with aortic aneurysm (AA), peripheral artery disease (PAD) and arterial thrombosis and embolisation (ATE) in locations other than the heart and brain.METHODS: Nationwide Swedish family study. Data from the Swedish Multi-Generation Register for subjects aged 0-78 years old, coveri

OBJECTIVES: In Sweden, two centres perform lung transplantation for a population of about 9 million and the entire population is covered for lung transplantation by government health insurance. Lund University Hospital is one of these centres. This retrospective report reviews the 25-year experience of the Skåne University Hospital Lung Transplant Program with particular emphasis on short-term out

The increasing importance being placed on waste prevention in Swedish wastegovernance raises the question of how waste prevention is defined in practice.This paper presents a qualitative analysis of a sample of fifty-one key Swedishwaste prevention initiatives with the purpose of identifying which kind ofactions are imagined, promoted, and set into motion under the label of wasteprevention. The an

Forestry and nature conservation can benefit from rapid on-line information on forest disturbances, such as insect attacks. This type of information would facilitate timely field studies and enable more rapid counter measures, as well as enable studies of the dynamics of an insect outbreak. In this study we developed a method based on MODIS derived NDVI for near real-time monitoring of insect indu

While previous research has advocated the use of online sales channels as a driver for international expansion, the nature of the relationship between e-commerce and international sales is still unexplored. The purpose of this paper is to create a parsimonious model where we investigate whether, and to what extent, strategies pertaining to the geographical scope of international operations moderat

The dynamics of the temperature induced transformation between low and high temperature adsorption phases of Rb on Al(111) has been followed by high resolution core level spectroscopy. Particular emphasis has been paid to the order-preserving transformation between the low and high temperature Al(111)-Rb-(√3 × √3)R30° structures in which Rb atoms occupy on-top and substitutional sites, respectivel

OBJECTIVES: To evaluate the safety of intra-articular sprifermin (primary), and to evaluate systemic exposure, biomarkers, histology, and other cartilage parameters in patients with advanced osteoarthritis (OA).METHODS: This was a first-in-human, double-blind, randomised, placebo-controlled trial of single and multiple ascending doses of sprifermin from 3-300 μg in knee OA patients scheduled for t

BACKGROUND: The critical role of the immune system in controlling cancer progression has become evident and immune modulatory therapy is now approved for clinical use. However, while the majority of studies on the inflammatory tumour microenvironment have focused on the cellular immune response, in particular the prognostic and predictive role of various T cell infiltrates, the role of the humoral

The O 1s core level of three different Bi-Sr-Ca-Cu-O superconductors has been studied by means of high-resolution x-ray-photoelectron spectroscopy (XPS) and x-ray-absorption spectroscopy (XAS). The O 1s XPS spectra could be decomposed into three components that were unambiguously assigned to the emission from the three different oxide layers in the crystal structure. These are, in order of increas

Alkali-metal-induced satellite peaks associated with the K 3p and Al 2p core levels have been measured with photoemission for K/Al(111) and K/Al(100) under both low- and room-temperature preparation conditions. For low-temperature deposition we observedddd loss peaks in good agreement with electron-energy-loss spectroscopy studies of analogous systems which we assign to the excitation of collectiv

High resolution core level photoemission measurements are reported of the binding energy shifts of the 3d core level of Mo, Rh and Pd atoms in interfaces between these 4d metals and alkali metals. The core level binding energies of the interface 4d atoms are found to be almost equal to those of the clean surface atoms for Mo and Rh. For Pd a large alkali induced shift towards higher binding energy

The low temperature coadsorption of Na and Rb on an Al(111) surface is examined with a combination of LEED and core level photoemission spectroscopy. We observe LEED pattern sequences and alkali core level binding energies which are consistent with a net total alkali coverage and can be explained by Na-Rb repulsion, segregation, and islanding, though other models cannot be definitely excluded.

Denna avhandling studerar den moraliska konfliktlinje som genomsyrade den frihetstida politiken åren kring 1740 och som strukturerade politiken enligt en särskilt moralpolitisk logik. Logiken hade sin grund i dels samhällsordningens absoluta och normativt oföränderliga karaktär, dels ett antal djupa förmoderna erfarenheter av och förväntningar på människan som oförmögen att hantera sin fördärvade This thesis examines the moral conflict permeating the politics of Sweden’s Age of Liberty around 1740 – a conflict that also structured the politics of the time in relation to a particular political logic based on moral. This logic was based on the absolute and normatively immutable nature of the social order, but also on a number of deep pre-modern experiences and expectations of man as unable t

We present time-resolved X-ray absorption measurements of vanadium dioxide using ionizations radiation generated by a femtosecond pulsed laser source in combination with superconducting microcalorimeters capable of measuring energies of individual radiation quanta.

Introduction: Giant-cell tumor of bone (GCTB) is a locally aggressive histologically benign neoplasm with a less common malignant counterpart. Longitudinal data sources on GCTB are sparse, limited to single institution case series or surgical outcomes studies. The Swedish Cancer Registry is one of the few national population-based databases recording GCTB, representing a unique source to study GCT