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The clinically relevant polyamine analogue N-1,N-11-diethylnorspermine (DENSPM) inhibits cell growth by down-regulating polyamine biosynthesis, up-regulating polyamine catabolism at the level of spermidine/spermine N-1-acetyltransferase (SSAT), and depleting intracellular polyamine pools. Among human melanoma cell lines, the analogue causes rapid apoptosis in SK-MEL-28 cells and a sharp G(1) arres

Gaze coordinates are recorded from naive subjects watching a number of video clips. These are used to derive volumes of interest (VOIs) representing the mutual visual interest of the tested subjects. Video frames are then processed in variable resolution contingent on the VOI shapes to produce off-line foveated video. We report on bit rate savings between 30 and 54% due to off-line foveation proir

Inhibition of cell growth is the most commonly used endpoint for in vitro toxicity of biomaterials. The use of several different endpoints might however generate more information concerning the nature of the toxicity. Thus, we examined the toxicity of two biomaterials, Polyvinylchloride (PVC) and Polyoximethene (POM), with different selected endpoints. The influence of cell growth on these endpoin

Diffuse large B-cell lymphoma (DLBCL) has been shown to be comprised of at least two prognostic entities, depending on its resemblance to normal germinal center or activated B cells, using global gene expression profiling. Also, the expression patterns of bcl-6, CD10 and IRF-4 ( also known as MUM1) have been suggested as alternative means of identifying the germinal- and nongerminal center ( activ

Analys av kärnfamiljen och könspolitiken i Pete Walkers skräckfilmer med fokus på filmen Frightmare

Cultural and moral dimensions of waste.

Popular Abstract in Swedish Denna avhandling beskriver studier av de mekanismer varmed bakterien Streptococcus pyogenes undviker komplementdeposition och fagocytos.Phagocytosis of Streptococcus pyogenes is complement dependent. However, the cell wall-associated M protein, which exists in >100 different serotypes (M types), enables the bacteria to evade phagocytosis. To analyze the mechanisms by which M protein confers this ability we used, as model systems, two representative M proteins, the M22 and M5 proteins, which have properties typical for many M prote

This essay is an inquiry into manorial production in Scania. Its growth was dependent on the long-term development of European grain prices. When prices increased landlords were encouraged to put more land under the plough. The estates' main income came, to an increasing extent, from demesne production, which finally dominated the income profile. The peasants' most important contribution to the la

Intentional communication is perceptually based and about attentional objects. Three attention mechanisms are distinguished: scanning, attention attraction, and attention-focusing. Attention-focusing directs the subject towards attentional objects. Attention-focusing is goal-governed (controlled by stimulus) or goal-intended (under the control of the subject). Attentional objects are perceptually

When mourning pets, costoms and rituals are in many ways similar to what is used for humans. Whether one likes it or not, the market for pets, dead or alive is an expanding and lucrative one.

1. The objective of the present study was to examine the role of the endothelial selectins (i.e. P- and E-selectin) in leukocyte-endothelium interactions in colonic venules by use of intravital microscopy. 2. Balb/c mice were exposed to dextran sodium sulphate (DSS) in the drinking water for 5 days or treated intraperitoneally (i.p.) with tumour necrosis factor-alpha (TNF-alpha) for 3 h. 3. In DSS