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Coronary flow and reactivity, but not arrhythmia vulnerability, are affected by cardioplegia during cardiopulmonary bypass surgery of piglets

Introduction: Cardiopulmonary bypass (CPB) surgery remains associated with significant cardiovascular morbidity in both pediatric and adult patients but the mechanisms are not fully clarified. Abnormalities in coronary flow and function have beensuggested to play an important role. A few prior studies suggested protective effects on coronary and myocardial function by short intravenous (i.v.) infu

Early repolarization in children with unexplained syncope

Introduction: It has traditionally been believed that early repolarization (ER) is benign. Significant association between ER and sudden cardiac arrest due to idiopathic ventricular fibrillation was recently found in a large cohort of adult survivors of sudden cardiac arrest. In some prior studies, unexplained syncope has been linked to risk of sudden death, but the mechanisms remain speculative.W

Surgical age and morbidity after arterial switch of transposition of the great arteries

Background: Although transposition of the great arteries (TGA) accounts for less than 5% of congenital heart disease, the clinical course is often dramatic with need for early diagnosis and careful preoperative care as well as advanced surgical correction and postoperative support. Since 1993, Lund is one of the two tertiary referral centers for pediatric cardiac surgery in Sweden, with nearly 400

Infections and endothelial cell apoptosis

Objectives: Endothelial cells of coronary arteries undergo apoptosis in patients with coronary artery disease. Carotid artery ultrasound studies show that after acute infections intima media thickness is increased. The possible effects of infections on endothelial cell apoptosis and the presence of apoptosis in early life remain unknown. Methods: Chlamydia pneumonia was inoculated three times at t

Search for the standard model Higgs boson produced in association with a vector boson and decaying into a tau pair in pp collisions at s =8 TeV with the ATLAS detector

A search for the standard model Higgs boson produced in association with a vector boson with the decay H→ττ is presented. The data correspond to 20.3 fb-1 of integrated luminosity from proton-proton collisions at s=8 TeV recorded by the ATLAS experiment at the LHC during 2012. The data agree with the background expectation, and 95% confidence-level upper limits are placed on the cross section of t

Ventricular kinetic energy in young fontan patients

Introduction: Four-dimensional (4D) flow magnetic resonance imaging (MRI) enables kinetic energy (KE) quantification of intraventricular blood flow. In this study we aimed to quantify the KE in in patients with univentricular heart and to assess the change in the KE after different types of interventions. Methods: 4D flow MRI was acquired in patients with Fontan circulation (n=12; median age 12, r

Serum biomarkers of early stages of hypertrophic cardiomyopathy in a young population

Background: Hypertrophic cardiomyopathy (HCM) is the most common monogenic cardiac disorder and the leading cause of sudden cardiac death in the young. Although in a majority of HCM cases there are gene mutations coding for sarcomere proteins, the onset for the clinical consequences of these mutations are difficult to predict, as these mutations do not show any clear relationship to the degree of

Measurements of W±Z production cross sections in pp collisions at s =8 TeV with the ATLAS detector and limits on anomalous gauge boson self-couplings

This paper presents measurements of W±Z production in pp collisions at a center-of-mass energy of 8 TeV. The gauge bosons are reconstructed using their leptonic decay modes into electrons and muons. The data were collected in 2012 by the ATLAS experiment at the Large Hadron Collider and correspond to an integrated luminosity of 20.3 fb-1. The measured inclusive cross section in the detector fiduci

Reconstruction of hadronic decay products of tau leptons with the ATLAS experiment

This paper presents a new method of reconstructing the individual charged and neutral hadrons in tau decays with the ATLAS detector. The reconstructed hadrons are used to classify the decay mode and to calculate the visible four-momentum of reconstructed tau candidates, significantly improving the resolution with respect to the calibration in the existing tau reconstruction. The performance of the

Search for the Standard Model Higgs boson decaying into bb¯ produced in association with top quarks decaying hadronically in pp collisions at √s = 8 TeV with the ATLAS detector

A search for Higgs boson production in association with a pair of top quarks (tt¯ H) is performed, where the Higgs boson decays to bb¯, and both top quarks decay hadronically. The data used correspond to an integrated luminosity of 20.3 fb−1 of pp collisions at √s = 8 TeV collected with the ATLAS detector at the Large Hadron Collider. The search selects events with at least six energetic jets and

Muon reconstruction performance of the ATLAS detector in proton–proton collision data at s=13 TeV

This article documents the performance of the ATLAS muon identification and reconstruction using the LHC dataset recorded at s=13 TeV in 2015. Using a large sample of J/ ψ→ μμ and Z→ μμ decays from 3.2 fb- 1 of pp collision data, measurements of the reconstruction efficiency, as well as of the momentum scale and resolution, are presented and compared to Monte Carlo simulations. The reconstruction

Measurement of the transverse momentum and ϕη∗ distributions of Drell–Yan lepton pairs in proton–proton collisions at √ s = 8 TeV with the ATLAS detector

Distributions of transverse momentum pT ℓℓ and the related angular variable ϕη∗ of Drell–Yan lepton pairs are measured in 20.3fb-1 of proton–proton collisions at √ s = 8 TeV with the ATLAS detector at the LHC. Measurements in electron-pair and muon-pair final states are corrected for detector effects and combined. Compared to previous measurements in proton–proton collisions at √ s = 7 TeV, these

Centrality dependence of charged jet production in p–Pb collisions at √sNN = 5.02 TeV

Measurements of charged jet production as a function of centrality are presented for p–Pb collisions recorded at √sNN = 5.02 TeV with the ALICE detector. Centrality classes are determined via the energy deposit in neutron calorimeters at zero degree, close to the beam direction, to minimise dynamical biases of the selection. The corresponding number of participants or binary nucleon–nucleon collis

Differential studies of inclusive J/ψ and ψ(2S) production at forward rapidity in Pb-Pb collisions at √sNN = 2.76 TeV

The production of J/ψ and ψ(2S) was studied with the ALICE detector in Pb-Pb collisions at the LHC. The measurement was performed at forward rapidity (2.5 < y < 4) down to zero transverse momentum (pt) in the dimuon decay channel. Inclusive J/ψ yields were extracted in different centrality classes and the centrality dependence of the average pt is presented. The J/ψ suppression, quantified with th

Particle identification in ALICE: a Bayesian approach

We present a Bayesian approach to particle identification (PID) within the ALICE experiment. The aim is to more effectively combine the particle identification capabilities of its various detectors. After a brief explanation of the adopted methodology and formalism, the performance of the Bayesian PID approach for charged pions, kaons and protons in the central barrel of ALICE is studied. PID is p

Measurement of jet charge in dijet events from s =8 TeV pp collisions with the ATLAS detector

The momentum-weighted sum of the charges of tracks associated to a jet is sensitive to the charge of the initiating quark or gluon. This paper presents a measurement of the distribution of momentum-weighted sums, called jet charge, in dijet events using 20.3 fb-1 of data recorded with the ATLAS detector at s=8 TeV in pp collisions at the LHC. The jet charge distribution is unfolded to remove disto

Pharmaceutical lobbying and pandemic stockpiling of Tamiflu: a qualitative study of arguments and tactics

Background Little is known about how pharmaceutical companies lobby authorities or experts regarding procurement or the use of vaccines and antivirals. This paper investigates how members of Denmark's pandemic planning committee experienced lobbying efforts by Roche, manufacturer of Tamiflu, the antiviral that was stockpiled before the 2009 A(H1N1) pandemic. Methods Analysis of interviews with six

Repeat Immigration: A Previously Unobserved Source of Heterogeneity?

AIMS:Register data allow for nuanced analyses of heterogeneities between sub-groups which are not observable in other data sources. One heterogeneity for which register data is particularly useful is in identifying unique migration histories of immigrant populations, a group of interest across disciplines. Years since migration is a commonly used measure of integration in studies seeking to unders