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Effect of environmental and clinical factors on lung function and respiratory symptoms in adolescents with alpha1-antitrypsin deficiency

Individuals identified in the Swedish neonatal alpha1-antitrypsin (AAT) screening study were followed prospectively from their first to their eighteenth year of life. The aim of this study was to analyse the effect of environmental factors, i.e. active and passive smoking, and of clinical factors on lung function and the occurrence of respiratory symptoms in AAT-deficient adolescents. The study gr

A 9-DOF Tractor-Semitrailer Dynamic Handling Model for Advanced Chassis Control Studies

A nonlinear dynamic handling model for a tractor-semitrailer combination vehicle is presented in this report. The equations of motion are derived from the fundamental equations of dynamics in Euler's formulation without approximations. The model is modular in the sense that it is easy to change axle configuration, tyre model, suspension model, or to add new features. The primary aim of the model i

Age, gender, and fragility fractures are associated with differences in quantitative ultrasound independent of bone mineral density

Bone strength is determined by bone mineral density (BMD) and bone structure. Dual-energy X-ray absorptiometry (DXA) measures BMD. Whether quantitative ultrasound (qUS) measures a property of bone distinct from BMD is uncertain. To evaluate this, DXA and qUS were measured in 58 fracture patients and 428 controls. To study the independent effects of age and gender on qUS measurements and control fo

Life-history evolution in harvested populations: the role of natural predation

Models and experiments of the evolution of age- and/or size-at-maturation in response to population harvesting have consistently shown that selective harvesting of older and larger individuals can cause earlier maturation. These predictions, however, are all based on single-species considerations and thus crucially neglect the selective forces caused or mediated by species interactions. Here we de

Social mobility, marital status, and mortality risk in an adult life course perspective: The Malmo preventive project

Aims: Adverse social factors predict increased mortality. This study aimed to assess the influence of social class and marital status on mortality, adding an adult life course perspective. Methods: In total, 32,907 males and 20,204 females were evaluated based on census data in Malmo, Sweden. Of these subjects, 22,444 males and 10,902 females also took part in health screening. The main outcomes w

Women - a neglected risk group for atherosclerosis and vascular disease

Women are a neglected group for cardiovascular disease. Whereas young women tend to have lower incidences of coronary artery disease, stroke and myocardial infarctions than men, the situation changes drastically at menopause, after which women are at greater risk than men. Despite this, women at all ages receive less treatment, less attention and not enough information about health risks. Most ris

Welfare effects of controlling labor supply: an application of the stochastic Ramsey model

In this paper we extend Merton's (Rev. Econom. Stud. 42 (1975) 375) classic stochastic version of the Ramsey model by allowing the government to control the expected growth rate of the labor supply. We characterize the solution to this control problem for general time-separable preferences, and derive an analytical solution for the CRRA case. The results show to what extent the planner, or governm

Safety culture in Swedish air traffic control

European air traffic control is undergoing changes in organization and technology in order to increase efficiency in air traffic. Change processes can have a negative impact on existing safety cultures, the foundations of safety work, and on safety. This paper reports on an assessment of safety culture at one administrative and two operative units in a Swedish air traffic control setting, using qu

Statistical rate allocation for layered space-time structure

We propose a modified layered structure for multiple-input multiple-output systems, where the layer detection order is fixed and the data rate for each layer is allocated based on the detection order and channel statistics. Using a Gaussian approximation of the layer capacities, we derive an asymptotic optimum data-rate-allocation approach. For optimum data-rate allocation, the amount of backoff f

Extracellular nucleotides induce vasodilatation in human arteries via prostaglandins, nitric oxide and endothelium-derived hyperpolarising factor.

1. The present study was aimed at examining P2 receptor-mediated vasodilatation in human vessels. The isometric tension was recorded in isolated segments of the human left internal mammary artery branches precontracted with 1 muM noradrenaline. 2. Endothelial denudation abolished the dilator responses. 3. The selective P2Y1 agonist, 2-MeSADP, induced a potent vasodilatation (pEC50=6.9plusminus0.1)