Statistical inference for extremes has been a subject of intensive research over the past couple of decades. One approach is based on modelling exceedances of a random variable over a high threshold with the generalized Pareto (GP) distribution. This has proved to be an important way to apply extreme value theory in practice and is widely used. We introduce a multivariate analogue of the GP distri

Background: Antipericyte autoantibodies (APAAs) are present in high frequency among diabetic subjects with and without nonproliferative retinopathy. This study aimed to determine whether progression of retinopathy in type 2 diabetes was associated with the same medical risk factors in APAA-positive subjects as in APAA-negative subjects. Methods: Type 2 diabetic patients with nonproliferative diabe

The way relationships between symbols and thoughts are created is a general problem in learning, mainly described as "how students' learn to mean". This general problem raises some basic questions concerning how students' relate understanding to words used in learning. The present research provides an alternative perspective on the relationship between thought and language derived from the phenome

We investigate in detail the effect of electron and light- and heavy-hole state mixing on the transmission coefficients and current-voltage characteristics of interband tunnelling broken-gap heterostructures in the presence of a quantizing magnetic field perpendicular to the interfaces. Double-barrier and barrierless resonant tunnelling structures made from InAs, A1Sb, and GaSb are considered. The

There is growing evidence that several antibiotics exert their beneficial effect not only by inhibiting or killing bacterial pathogens but also by down-regulating pro-inflammatory mechanisms. This review aims to give an overview of the immunomodulatory properties of macrolide antibiotics in chronic rhinosinusitis and to present a treatment algorithm for managing the difficult CRS patient with long

The aim of this paper is to explore relations between science and the public. Specifically, Swedish meteorology around 1900 and the role of media relations in the construction of a storm-warning system will be discussed. It is argued that science - public interaction can be a factor in the process of establishing priorities in science.

This group previously identified a peptide p13 of alpha 3(IV)NC1 domain of type IV collagen that induces experimental autoimmune glomerulonephritis (EAG) in rats with generation of antibodies to sites on alpha 3(IV)NC1 external to the peptide as a result of intramolecular epitope spreading. It was hypothesized that intermolecular epitope spreading to other collagen IV chains also was induced. Rats

Abstract is not available

ABSTRACT: We plan to conduct a case-control study to investigate whether exposure to nitrogen dioxide (NO2) increases the risk of stroke. In case-control studies, selective participation can lead to bias and loss of efficiency. A two-phase design can reduce bias and improve efficiency by combining information on the non-participating subjects with information from the participating subjects. In ou

Objective. To investigate whether measurements of proinsulin and/or intermediate proinsulin degradation products could be used to differentiate between autoimmune (type 1) and non-autoimmune (type 2) diabetes in young adults. Material and methods. Total proinsulin, intact proinsulin and 32,33 split proinsulin concentrations were measured in 25 patients aged 15-34 years with type 1 diabetes, as def

We report evidence for a robust magnetic compass response in C57BL/6J mice. Mice were trained to build their nests in one of four magnetic directions by creating a light gradient along the long axis of a rectangular cage and positioning a nest box at the opposite (dark) end. The mice were then tested overnight in a circular, visually symmetrical arena in one of four magnetic field alignments. The

China's transition from planned to market economy is at present one of the topics most discussed among researchers. According to almost any version of mainstream property rights theory, the rapid privatization or what has been described as the "East European model" basically represents the correct approach to transformation, while the gradual transition, or the "Chinese model", should represent a

We describe a novel method for determining weak association constants of oligomeric protein complexes formed transiently under equilibrium conditions. This type of equilibrium process is recognized as being biologically important, but generally hard to study. Heteronuclear spin relaxation rates measured at multiple protein concentrations are analyzed using relaxation rates predicted from hydrodyna